Innovative Grade US Origin Guinea Pig Plasma from Innovative Research was recently used in the following study:

Determination of Phosphodiesterase Inhibitors Tadalafil, Roflumilast and Roflumilast N-Oxide Using LC-MS in Guinea Pig Plasma

Martin Kertys, Anna Urbanova, and Juraj Mokry
Journal of Chromatographic Science: 10 July 2018

" ... K3 EDTA guinea pig plasma (blank plasma) was purchased from Innovative Research (Novi, MI, USA) ... in this study we decided to develop a rapid, specific and sensitive method using LC"MS-MS coupled with an easy and fast sample preparation by protein precipitation for the TD, RF and RFN determination in guinea pig plasma. The method was fully validated in terms of selectivity, stability, linearity, precision and accuracy for guinea pig plasma... "

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Human Plasminogen Total ELISA Kit from Innovative Research was recently used in the following study:

Urinary Plasmin(ogen) as a Prognostic Factor for Hypertension

Evan C. Ray, MD, PhD, Rachel G. Miller, PhD, John E. Demko, MD, Tina Costacou, PhD, Carol L. Kinlough, PhD, Casey L. Demko, MS, Mark L. Unruh, MD, Trevor J. Orchard, MD, Thomas R. Kleyman, MD
Kidney International Reports (2018)

"... For urinary plasmin(ogen) measurement in the present study, archived specimens stored at -80 ˚C were
thawed on ice and centrifuged at 10,000 g for 15 minutes at 4 ˚C to remove particulate matter. Specimens were then diluted 10 to 100-fold before plasmin(ogen) measurement via ELISA (Innovative Research, Novi, MI). Although this method does not distinguish active plasmin from plasminogen, results using this assay correlate well with urine plasmin as measured by immunoblot."

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Porcine Red Blood Cells, Packed 10% from Innovative Research was recently used in the following study:

Hydrolytically Degradable PEGylated Polyelectrolyte Nanocomplexes for Protein Delivery

Alexander K. Andrianov, Alexander Marin, Andre P. Martinez, Jacob L. Weidman, and Thomas R. Fuerst
Biomacromolecules: June 28, 2018

"... porcine red blood cells (Innovative Research, Novi, MI) ... Macromolecular modules for the construction of "core-shell" structured nano-assemblies were designed to include three main features - ionic moieties for enabling electrostatic interactions in the core, grafted PEG chains for forming the hydrophilic shell, and hydrolytically labile bonds to facilitate polymer degradation ..."

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Pooled Normal Human Urine from Innovative Research was recently used in the following study:

A novel diagnostic in situ derivatization kit for the simultaneous determination of 14 biomarkers of exposure to benzene, toluene, ethyl benzene and xylenes in human urine by isotope dilution liquid chromatography tandem mass spectrometry and kit optimization using response surface methodology.

Yehia Z.Baghdady, Kevin A.Schug
Analytica Chimica Acta, 26 June 2018

"...The goal of this work was to develop and optimize a novel combination of a one-pot derivatization in situ [30] kit (OPDISK) that can be directly integrated with LC-ESI-MS/MS for the simultaneous quantitation of 14 phenolic and carboxylic biomarkers of BTEX in human urine .... Pooled normal human urine was purchased from Innovative Research (Novi, MI) ... A series of working solutions of analytes were prepared from individual stocks by successive dilutions with acetonitrile and the calibration standards were then prepared by spiking 50 mL pooled human urine with 50 mL working solutions of the desired concentrations..."

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Rat IgG (Fractionated Purified) from Innovative Research was recently used in the following study:

Use of Cyclodextrin as a Novel Agent in the SEC-HPLC Mobile Phase to Mitigate the Interactions of Proteins or Peptide or their Impurities with the Residual Silanols of Commercial SEC-HPLC Columns with Improved Separation and Resolution

Javeri, I., Nellaiappan, K., McNemar, C. et al.
Pharmaceutical Research: September 2018, 35:168

"... Purified rat polyclonal IgG formulated in PBS at pH 7.4 was purchased from Innovative Research Novi, MI 48377... Rat IgG powder was diluted to 1 mg/mL using PBS before injection. All monoclonal antibodies formulated in product specific inactive excipients, which includes, buffer, salt, and or bulking agents such as
Trehalose or Sucrose providing stability to the protein..."

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Human Prorenin ELISA Kit for Non Plasma Samples from Innovative Research was recently used in the following study:

Aliskiren reduces the release of soluble (pro)renin receptor from human umbilical vein endothelial cells

Shinji Yamashita, Kazal Boron Biswas, A.H.M. Nurun Nabi, Tsutomu Nakagawa, Fumiaki Suzuki, Akio Ebihara.
Biomedical Reports: Published online on July 5, 2018

"... The concentration of purified prorenin was measured using a human prorenin enzyme-linked immunosorbent assay (ELISA) kit (cat no. IHPRENKT-NP; Innovative Research, Inc., Novi, MI, USA). Prior to experimentation, purified prorenin was incubated at 37C for 1 h (23) to avoid cryo-activation due to preservation (24) ..."

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Mouse Albumin ELISA Kit from Innovative Research was recently used in the following study:

The Role of Macrophages in the Sequestration of Drug and Formation of Insoluble Drug Aggregates

Phillip Rzeczycki
A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy (Pharmaceutical Sciences) In The University of Michigan 2018.

...Albumin was assayed by ELISA (Innovative Research, Novi, MI) ... Cellular and biochemical analyses of BAL fluid to assess lung injury revealed that CFZ treatment reduced the LPS-induced BAL fluid cell count (Fig. 5C) and reduced the BAL fluid albumin concentrations (Fig. 5D).

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Balb C Mouse Serum from Innovative Research was recently used in the following study:

Quantitative Assessment of Nanoparticle Biodistribution by Fluorescence Imaging, Revisited

Fanfei Meng, Jianping Wang, Qineng Ping, and Yoon Yeo
ACS Nano, Publication Date (Web): June 19, 2018.

Upon incubation in mouse serum, ICG was quickly released from the NPs and detected in the supernatant as early as in 10 min, whereas DiR was stably retained in the NPs over 6 h (duration of the observation) (Figure S1). Free DiR dispersed in mouse serum showed no fluorescence (Figure S2) due to the formation of H-aggregates.... Balb/c mouse serum was purchased from Innovative research (Novi, MI, USA).

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Normal Single Donor Human Plasma from Innovative Research was recently used in the following study:

A sensitive liquid chromatography-tandem mass spectrometry method for the quantification of valacyclovir and its metabolite acyclovir in mouse and human plasma

Jian Shi, Yongjun Hu, David E. Smith, Hao-Jie Zhu
Journal of Chromatography B: Volume 1092, 15 August 2018, Pages 447-452

... Blank human plasma was obtained from Innovative Research Inc. (Novi, MI) ... Five different lots of blank mouse and human plasma were used to assess the matrix effects. Two sets of samples were prepared. Set A: phosphate-buffered saline spiked with ACV (10, 2000 nM), VACV (10, 2000 nM) and ISs (200 nM); Set B: extracted plasma mixed with ACV (10, 2000 nM), VACV (10, 2000 nM) and ISs (200 nM). The percentage of matrix effect was calculated as (b / a) * 100, where a and b are the peak areas of ACV, VACV, and IS in sets A and B, respectively.

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Sprague Dawley Rat Serum from Innovative Research was recently used in the following study:

The inhibition, reactivation and mechanism of VX-, sarin-, fluoro-VX and fluoro-sarin surrogates following their interaction with HuAChE and HuBuChE

Chih-Kai Chao, Narayanaganesh Balasubramanian, John M. Gerdes, Charles M. Thompson
Chemico-Biological Interactions: Volume 291, 1 August 2018, Pages 220-227

... Serum from Sprague-Dawley rats was purchased from Innovative Research (Novi, MI). Paraoxon was available from prior studies and purified to > 98% on silica gel immediately prior to use. Note: OPs are hazardous and require gloves and adequate ventilation. OP compounds that come in contact with glassware and plasticware should be immersed in 1.0 M NaOH for decontamination.

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Single Donor Human Whole Blood from Innovative Research was recently used in the following study:

Metformin-Loaded Hyaluronic Acid Nanostructure for Oral Delivery

Sonal Bhujbal, Alekha K. Dash
AAPS PharmSciTech (2018).

... Whole human blood was obtained commercially from Innovative Research Inc. (Novi, MI). This blood was collected from a 55-year-old Hispanic male ...

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Single Donor Human Serum from Innovative Research was recently used in the following study:

Prevalence of Pre-existing Antibodies to CRISPR-associated Nuclease Cas9 in the US Population

Simhadri VL, McGill J, McMahon S, Wang J, Jiang H, Sauna ZE
Molecular Therapy: Methods & Clinical Development (2018)

... Serum samples from healthy donors were purchased from Innovative Research (Innovative Research, Novi, MI) and stored at -80oC until analysis. SaCas9 and SpCas9 proteins were custom-produced ...

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Single Donor Human Whole Blood from Innovative Research was recently used in the following study:

A photoelectrochemical platform for the capture and release of rare single cells

Stephen G. Parker, Ying Yang, Simone Ciampi, Bakul Gupta, Kathleen Kimpton, Friederike M. Mansfeld, Maria Kavallaris, Katharina Gaus & J. Justin Gooding
Nature Communications: Volume 9, Article number: 2288 (2018)

... Single donor human whole blood was purchased from innovative research (Novi, MI, USA) and treated with K2 EDTA to prevent coagulation ...

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Rat Plasma from Innovative Research was recently used in the following study:

Simultaneous measurement of folate cycle intermediates in different biological matrices using liquid chromatography-tandem mass spectrometry

Jatin Nandania, Meri Kokkonen, Liliya Euro, Vidya Velagapudi
Journal of Chromatography B: Volume 1092, 15 August 2018, Pages 168-178

... Rat plasma with heparin as the anticoagulant was purchased from Innovative Research Laboratory (Novi, MI, USA). Whole human blood was procured from the ...

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CD-1 Mouse Red Blood Cells from Innovative Research was recently used in the following study:

Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria

Ming Yang, Chunye Zhang, Michael Z. Zhang and Shuping Zhang
BMC Microbiology 2018 18:54

... The hemolytic assay was performed as described previously 25. Briefly, mouse red blood cells (RBCs, Innovative Research, Novi, MI) were washed three times with phosphate-buffered saline (PBS, pH 7.4), centrifuged at 1000xg for 10 min, and resuspended in PBS to 10% (v/v). The RBCs were treated with ...

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Rat tPA ELISA Kit (available in Rat Active tPA ELISA and Rat Total tPA ELISA) and Rat PAI-1 ELISA Kit (available in Rat Active PAI-1 ELISA and Rat Total PAI-1 ELISA) from Innovative Research were recently used in the following study:

Plasminogen activator system homeostasis and its dysregulation by ethanol in astrocyte cultures and the developing brain

Clare J. Wilhelm, Joel G. Hashimoto, Melissa L. Roberts, Xiaolu Zhang, Calla M. Goeke, Shelley H. Bloom, Marina Guizzetti
Neuropharmacology: Volume 138, August 2018, Pages 193-209

... Levels of tPA were determined in lysates from rat cortices, hippocampi, and mixed-sex astrocyte cultures using a tPA enzyme-linked immunosorbent assay (ELISA) kit (Innovative Research, Novi, MI) as described in the manufacturer's protocol. Levels of PAI-1 were determined in lysates from rat cortices and mixed-sex astrocyte cultures using a PAI-1 ELISA kit (Innovative Research, Novi, MI) as described in the manufacturer's protocol. tPA and PAI-1 concentrations in the samples were interpolated from their respective standard curves and normalized to total protein content...

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Single Donor Human Serum from Innovative Research was recently used in the following study:

A rapid immunochromatography test based on Hcp1 is a potential point-of-care test for serological diagnosis of melioidosis

Phornpun Phokrai, Wisansanee Karoonboonyanan, Nida Thanapattarapairoj , Chidchanok Promkong, Adul Dulsuk, Sirikamon Koosakulnirand, Sasha Canovali, Nitaya Indrawattana, Yaowaruk Jutrakul, Vanaporn Wuthiekanun, Direk Limmathurotsakul, Paul J. Brett, Mary N. Burtnick, Ganjana Lertmemongkolchai, Narisara Chantratita
J. Clin. Microbiol.

... in 130 northeast Thailand; (iii) sera from healthy donors from the U.S. (N = 90) (Innovative Research, Novi, MI, USA); and (iv) sera from patients with culture results ...

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Human Serum from Innovative Research was recently used in the following study:

Analysis of lipid adsorption on nanoparticles by nanoflow liquid chromatography-tandem mass spectrometry

Ju Yong Lee, Hua Wang, Georgios Pyrgiotakis, Glen M. DeLoid, Zhenyuan Zhang, Juan Beltran-Huarac, Philip Demokritou, Wenwan Zhong
Analytical and Bioanalytical Chemistry: 30 May 2018

Nanoparticles (NPs) tend to adsorb matrix molecules like proteins and lipids incubated with biological fluids, forming a biological corona ... Human serum was obtained from Innovative Research (Novi, MI, USA), which was donated...

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