Human Serum from Innovative Research was recently used in the following study:

Enhancing Treatment Efficacy of 177Lu-PSMA-617 with the Conjugation of an Albumin-Binding Motif: Preclinical Dosimetry and Endoradiotherapy Studies

Hsiou-Ting Kuo, Helen Merkens, Zhengxing Zhang, Carlos F. Uribe, Joseph Lau, Chengcheng Zhang , Nadine Colpo , Kuo-Shyan Lin , and François Bénard
Molecular Pharmaceutics, September 2018

"... All chemicals and solvents were obtained from commercial sources, and used without further purification. Human serum for protein binding assay was obtained from Innovative Research (Novi, MI)... Plasma protein binding assays were performed according to literature methods Briefly, 37 kBq of 177Lu-PSMA-617 or 177Lu-HTK01169 in 50 µL PBS was added into 200 µL human serum and the mixture was incubated at room temperature for 1 min..."

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Sprague Dawley Rat Plasma from Innovative Research was recently used in the following study:

Plasma ameliorates endothelial dysfunction in burn injury

Mariana Vigiola Cruz MD, Bonnie C. Carney BS, Jenna N. Luker MD, Kyle W. Monger BS, Juan Sebastian Vazquez MD, Lauren T. Moffatt PhD, Laura S. Johnson MD, Jeffrey W. Shupp MD
Journal of Surgical Research, January 2019

" ... Sprague-Dawley rats were used to create small, medium, and large burns and uninjured controls. Three different intravenous resuscitation protocols were applied within each group: Lactated Ringer's (LR) alone, LR plus fresh frozen plasma (FFP), or LR plus albumin... In the LR plus FFP group, animals were resuscitated identically to the LR-only group, except they were given a 0.45 mL intravenous injection of rat FFP (Innovative Research, Inc, Novi, MI) immediately after burn ("hour 0"), and at hours 2, 4, and 8.

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Pooled Normal Human Serum from Innovative Research was recently used in the following study:

Comparison of an Optimized Ultracentrifugation Method versus Size-Exclusion Chromatography for Isolation of Exosomes from Human Serum

Mingrui An, Jing Wu, Jianhui Zhu, and David M. Lubman
Journal of Proteome Research, September 2018

" ... The commercially available serum (Innovative Research, Novi, MI) was pooled from a cohort of 1500 to 3000 healthy normal humans. Each donor unit was tested and found negative for HIV 1&2, HCV, HBsAg, and PRP by FDA approved methods. The serum was stored at âˆ'80 oC until use. The initial volume of serum was 18 mL. It was diluted with an equal volume of PBS ... "

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Human Plasma with K2 EDTA from Innovative Research was recently used in the following study:

Development and validation of LC-MS/MS method for quantification of bictegravir in human plasma and its application to an intracellular uptake study

Pavan Kumar Prathipati, Subhra Mandal, Christopher J. Destache
Biomedical Chromatography, September 2018

" ... A sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for quantification of bictegravir in human plasma... Dipotassium ethylenediaminetetraacetic acid (K2EDTA) plasma was purchased from Innovative Research (Novi, MI)... Six different sources of K2EDTA human blank plasma were extracted and the peak areas at the retention time of analyte and internal standard were compared to the peak areas found in the lower limit of quantification (LLOQ, 1 ng/mL) to determine the selectivity of the assay..."

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Rabbit Red Blood Cells from Innovative Research were recently used in the following study:

Modulation of innate immunity in Nile tilapia (Oreochromis niloticus) by dietary supplementation of Bacillus subtilis endospores

Oscar A.Galagarza, Stephen A.Smith, David J.Drahos, Joseph D.Eifert, Robert C.Williams, David D.Kuhn
Fish & Shellfish Immunology, December 2018

"... The activity of the alternative complement pathway (ACH50) was measured by use of the method of hemolysis of rabbit red blood cells (RRBC; Innovative Research, Novi, MI, USA), as previously described 18. Plasma from tilapia from days 14, 28 and 51 were used for estimation of alternative complement activity ..."

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Single Donor Human Serum from Innovative Research was recently used in the following study:

Immune reactivity against a variety of mammalian milks and plant-based milk substitutes

Aristo Vojdani, Chris Turnpaugh, and Elroy Vojdani
Journal of Dairy Research, August 2018

"... Five hundred sera from a cross-spectrum population aged 18-65 were obtained from Innovative Research (Novi, MI, USA). The healthy subjects were tested according to FDA guidelines for the detection of hepatitis B surface antigen, antibodies to HIV, HIV-1 RNA, Hepatitis-C RNA, and syphilis. All samples yielded non-reactive or negative results for each test performed..."

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Pooled Normal Human Plasma from Innovative Research was recently used in the following study:

Effect of CYP2C9 Polymorphisms on the Pharmacokinetics of Indomethacin During Pregnancy

Mansi Shah, Meixiang Xu, Poonam Shah, Xiaoming Wang, Shannon M. Clark, Maged Costantine, Holly A. West, Tatiana N. Nanovskaya, Mahmoud S. Ahmed, Sherif Z. Abdel-Rahman, Raman Venkataramanan, Steve N. Caritis, Gary D. V. Hankins, Erik Rytting
European Journal of Drug Metabolism and Pharmacokinetics, August 2018

"... Plasma concentrations of indomethacin and DMI at steady state were analyzed with a validated LC-MS/MS method. DNA was isolated from subject blood and buccal smear samples. Subjects were grouped by genotype for comparisons of pharmacokinetic parameters ... Pooled blank human plasma was purchased from Innovative Research (Novi, MI) ..."

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Porcine Red Blood Cells Packed 10% from Innovative Research was recently used in the following study:

Hericium erinaceus isolectins recognize mucin-type O-glycans as tumor-associated carbohydrate antigens on the surface of K562 human leukemia cells

Seonghun Kim
Biological Macromolecules, August 2018

" ... Animal blood products and glycoconjugates [Galβ(1,3)GalNAc; Neu5Acα(2,3)Galβ(1,3)GalNAc; Galβ(1,6)GalNAc] were purchased from Innovative Research (Novi, MI, USA) and ... The hemagglutination activity of lectins was determined using the following twofold serial dilution procedure with intact erythrocytes. Lectin-containing solution (50 μL) was mixed with an equal volume of 4% (v/v) formaldehyde-treated porcine red blood cells suspended in PBS in individual wells of a 96-well microtiter plate ... "

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Normal Single Donor Human Plasma from Innovative Research was recently used in the following study:

Bioanalytical liquid chromatography-tandem mass spectrometric assay for the quantification of the ALK inhibitors alectinib, brigatinib and lorlatinib in plasma and mouse tissue homogenates

Rolf W. Sparidans, Wenlong Li, Alfred H. Schinkel, Jan H.M. Schellens, Jos H. Beijnen
Journal of Pharmaceutical and Biomedical Analysis, August 2018

" ... Several second and third generation ALK inhibitors have been introduced in recent years. A bioanalytical
assay for simultaneous quantification of alectinib, brigatinib, and lorlatinib was developed and validated for
human plasma. The method was also partially validated for diluted mouse plasma and tissue homogenates
of brain, liver, kidney, and spleen ... plasma of individual humans was provided by Innovative Research (Novi, MI, USA). "

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Cellulase from Innovative Research was recently used in the following study:

Enzymatic Synthesis, Characterization and Biocompatibility Studies of Cellulose Nanoparticles from Cotton Fibers

Prathima Prabhu Tumkur, Tejaswini Ronur Praful, Babu R Lamani, Nicole Nazario Bayn, Krishnan Prabhakaran, Joseph C Hall, and Govindarajan T Ramesh
Advances in Nanoscience and Nanotechnology, August 2018

" ... Cotton fibers obtained from Indian farm fields were used as a primary source for the enzymatic synthesize of cellulose nanoparticles. The cotton fibers were separated from cotton linkers and stored. The cellulase enzyme (IRWBE005-20866) used in hydrolysis was purchased from Innovative Research, Inc. (Peary Court Novi, MI) ... "

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Normal Human Plasma from Innovative Research was recently used in the following study:

HIV Integrase Inhibitor Pharmacogenetics and Clinical Outcomes: An Exploratory Association Study

Derek E. Murrell
East Tennessee State University Digital Commons, August 2018

"...Briefly, a standard curve ranging from 10 ng/mL to 1,500 ng/mL was created for drugs of interest from respective stock solutions in a 50:50 ratio of acetonitrile and water, using blank human plasma (Innovative Research Inc Novi, MI). Verapamil, a drug which no subject was concurrently receiving, was used as the internal standard in acetonitrile and 1% formic acid in water (80:20)..."

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Mouse PAI-1 ELISA Kit from Innovative Research was recently used in the following study:

Plasminogen activator inhibitor-1 serves an important role in radiation-induced pulmonary fibrosis

Sachiko Shioya, Takeshi Masuda, Tadashi Senoo, Yasushi Horimasu, Shintaro Miyamoto, Taku Nakashima, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori
Experimental and Therapeutic Medicine, August 2018

... PAI-1 and TGF-beta levels in BAL fluids were measured at 0, 4, 12, 18, and 24 weeks after irradiation using ELISA kits for PAI-1 (Innovative Research, Novi, MI, USA)... To determine the effect of thoracic irradiation on the expression of PAI-1 and TGF-beta in the lung, PAI-1 and TGF-beta levels in BAL fluid were measured using ELISA kits. In WT mice, PAI-1 levels in BAL fluids were unchanged from baseline until 12 weeks after irradiation but started increasing after 18 weeks and reached their highest levels at 24 weeks after irradiation..."

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Pooled Normal Human Serum from Innovative Research was recently used in the following study:

Therapeutic potential of staphylococcal superantigen-like protein 7 for complement-mediated hemolysis

Yan Li, Fiona Clow, John D. Fraser, Feng Lin
Journal of Molecular Medicine, September 2018

" ... Recombinant SSL7 and SSL7-C5a SSL7 mutant lacking C5 binding activity were overexpressed in Escherichia coli and purified following the protocol described in previous reports [16, 20]. Pooled normal human serum (NHS) as the source of complement was purchased from Innovative Research (Novi, MI)."

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Bovine Red Blood Cells from Innovative Research were recently used in the following study:

Separation of sub-micron particles from micron particles using acoustic fluid relocation combined with acoustophoresis

Gayatri P. Gautam, Rubi Gurung, Frank A. Fencl, Menake E. Piyasena
Analytical and Bioanalytical Chemistry, October 2018

" ... We demonstrate the proof of the concept using binary mixtures of particles comprised of sub-micron/micron particles, micron/micron particles, and bovine red blood cells with E. coli ... B-RBCs were purchased from Innovative Research (Novi, MI) ... To demonstrate the proof of the concept, fluorescent and non-fluorescent solutions with different mass densities, solutions containing mixtures of suspended micron particles
and sub-micron particles, E. coli, and B-RBCs were utilized; 2.5 uM fluorescein solutions were prepared by dissolving fluorescein sodium salt in D.I. water and 0.1X PBS. For the particle mixtures, fluorescent NR-ps with different diameters were suspended in D.I. water. B-RBCs and E. coli were diluted in 1X PBS buffer..."

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Sheep Red Blood Cells from Innovative Research were recently used in the following study:

Durable targeting of B-lymphocytes in living mice

M. Cascalho, D. Huynh, A. R. Lefferts, L. Stein, T. Lanigan, J. Decker, L. D. Shea & J. L. Platt
Scientific Reports (2018)

"... Transduction of CD19+ Cells in vivo: One hundred microliters of concentrated lentiviruses (3xMOI) were injected directly into the spleen (visualized and mobilized through laparotomy) in mice that had been immunized i.p. with 2.5 x 10^8 sheep red blood cells (Innovative Research, Novi, MI) 3 days before ..."

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Pooled Normal Human Saliva from Innovative Research was recently used in the following study:

Detection of unique Ebola virus oligonucleotides using fluorescently-labeled phosphorodiamidate morpholino oligonucleotide probe pairs

Yijia Xiong, Tammie J. McQuistan, James W. Stanek, James E. Summerton, John E. Mata, Thomas C. Squier
Analytical Biochemistry, July 2018

"... Upon EBOV target oligonulceotide binding, observed changes in FRET between PMO probe pairs permit a 25 pM lower limit of detection; there is no off-target binding within a complex mixture of nucleic acids and other biomolecules present in human saliva ... Pooled normal human saliva was from Innovative Research (IR100044P) (Novi, MI). Following removal of mucus (Zebra Spin Desalting Column, 7 kDa MWCO; ThermoFisher Scientific) and cellular disruption (8.0 M urea), the nucleotide concentrations in the isolated saliva was 0.3 mM ..."

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Normal Single Donor Human Plasma from Innovative Research was recently used in the following study:

Heterogeneous expression of cytokines accounts for clinical diversity and refines prognostication in CMML

Sandrine Niyongere, Nolwenn Lucas, Jun-Min Zhou, Samer Sansil, Anthony D. Pomicter, Maria E. Balasis, John Robinson, Jodi Kroeger, Qing Zhang, Yu Long Zhao, Markus Ball, Rami Komrokji, Alan List, Michael W. Deininger, Brooke L. Fridley, Valeria Santini, Eric Solary & Eric Padron
Nature: Lukemia, July 2018

"... Fifteen single donor healthy control plasma samples were purchased from Innovative Research (Innovative Research, Inc., Novi, MI) with an average age 66 (range 60-80) and a total of nine men and six women ..."

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Human Plasma with EDTA anticoagulant from Innovative Research was recently used in the following study:

Neuron-related blood inflammatory markers as an objective evaluation tool for major depressive disorder: An exploratory pilot case-control study

Nobuki Kuwano, Takahiro A. Kato, Masato Mitsuhashi, Mina Sato-Kasai, Norihiro Shimokawa, Kohei Hayakawa, Masahiro Ohgidani, Noriaki Sagata, Hiroaki Kubo, Takeshi Sakurai, Shigenobu Kanba
Journal of Affective Disorders, July 2018.

"...Since our sandwich ELISA method used a combination of 2 different target antibodies, such as anti-SNAP25 as a capture antibody, and anti-CD81, anti-SYP, anti-IL1beta, anti-IL6, anti-IL34, anti-TNFalpha, anti-TNFR1, or anti-OXR as a detection antibody, a purified or recombinant protein was not applicable as a quantification standard. Thus, we first screened various plasma samples obtained from commercial sources (Innovative Research..."

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