Product References — Pooled Human Complement Serum

Complement-dependent bystander injury to neurons in AQP4-IgG seropositive neuromyelitis optica

Posted by Leanne Kodsmann on

Complement-dependent bystander injury to neurons in AQP4-IgG seropositive neuromyelitis optica

Human Complement from Innovative Research was used in the following study:   Complement-dependent bystander injury to neurons in AQP4-IgG seropositive neuromyelitis optica Tianjiao Duan, Alex J. Smith and Alan S. Verkman Journal of Neuroinflammation, October 2018 "... Specified concentrations of AQP4-IgG (or control human IgG, Thermo Fisher Scientific, Rockford, IL) and human complement (Innovative Research, Novi, MI) were added in Hank’s buffer, and cells were incubated at 37 °C for specified times. In some experiments, cells were exposed to serum of an AQP4-IgG seropositive NMO patient who met the revised diagnostic criteria for clinical disease. A fixable dead-cell stain (amine-reactive dye,...

Read more →

Daratumumab binds to mobilized CD34+ cells of myeloma patients in vitro without cytotoxicity or impaired progenitor cell growth

Posted by Leanne Kodsmann on

Daratumumab binds to mobilized CD34+ cells of myeloma patients in vitro without cytotoxicity or impaired progenitor cell growth

Human Complement Serum from Innovative Research was used in the following study:   Daratumumab binds to mobilized CD34+ cells of myeloma patients in vitro without cytotoxicity or impaired progenitor cell growth Xun Ma, Sandy W. Wong, Ping Zhou, Chakra P. Chaulagain, Parul Doshi, Andreas K. Klein, Kellie Sprague, Adin Kugelmass, Denis Toskic, Melissa Warner, Kenneth B. Miller, Lisa Lee, Cindy Varga and Raymond L. Comenzo Experimental Hematology & Oncology, October 2018 "... Complement-rich human serum (CRHS) was from Innovative Research (Novi, MI), was aliquoted, cryopreserved and thawed for immediate use. For CDC studies, cells were aliquoted at 4 × 105 per well,...

Read more →

The effect of storage temperature on the biological activity of extracellular vesicles for the complement system

Posted by Leanne Kodsman on

Pooled Complement Human Serum from Innovative Research was recently used in the following study: The effect of storage temperature on the biological activity of extracellular vesicles for the complement system Sang June Park, Hyungtaek Jeon, Seung-Min Yoo, Myung-Shin LeeIn Vitro Cellular & Developmental Biology, May 2018. ... The cells were maintained in a humidified atmosphere of 5% CO2 at 37°C. Pooled complement human serum was purchased from Innovative Research, Inc. (Novi, MI) and used as normal human serum (NHS) in all experiments ... Related products available from Innovative Research also include: Single Donor Human Complement Serum Pooled Normal Human Serum...

Read more →

Bystander mechanism for complement-initiated early oligodendrocyte injury in neuromyelitis optica

Posted by Leanne Kodsman on

Innovative Research's Human Complement was recently used in the following study: Bystander mechanism for complement-initiated early oligodendrocyte injury in neuromyelitis optica L Tradtrantip, X Yao, T Su, AJ Smith, AS Verkman - Acta Neuropathologica, 2017 ... Complement dependent cytotoxicity Specified concentrations of AQP4-IgG (or control human IgG, Thermo Fisher Scientific, Rockford, IL) and human complement (Innovative Research, Novi, MI) were added in Hank's buffer, and cells were incubated at 37 °C for specified times. ...

Read more →

Pooled Complement Human Serum - May 31, 2017

Posted by Leanne Kodsman on

May 31, 2017 Innovative Research's Pooled Complement Human Serum was recently used in the following study: Bystander mechanism for complement-initiated early oligodendrocyte injury in neuromyelitis opticaL Tradtrantip, X Yao, T Su, AJ Smith, AS Verkman - Acta Neuropathologica, 2017 ... Complement dependent cytotoxicity Specified concentrations of AQP4-IgG (or control human IgG, Thermo Fisher Scientific, Rockford, IL) and human complement (Innovative Research, Novi, MI) were added in Hank's buffer, and cells were incubated at 37 C for specified times. ...

Read more →