Product References — Pooled Human Complement Serum

Single Donor Human Complement Serum from Innovative Research was used in the following study:   Cytoprotective IgG Antibodies in Sera from a Subset of Patients with AQP4‑IgG Seropositive Neuromyelitis Optica Spectrum Disorder LukmaneeTradtrantip, Michael R. Yeaman & A. S. Verkman Scientific Reports November 9, 2021 Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disorder that attacks the central nervous system and can cause demyelination in the optic nerve, spinal cord, and brain, and potentially cause further neurological deficits. Over 70% of patients suffering from NMOSD are seropositive for IgG autoantibodies which target extracellular epitopes of astrocyte water channel aquaporin-4 (AQP4),...

Pooled Human Complement Serum from Innovative Research was used in the following study:   Photoreactive Carboxybetaine Copolymers Impart Biocompatibility and Inhibit Plasticizer Leaching on Polyvinyl Chloride Xiaojie Lin, Kan Wu, Qiong Zhou, Priyesh Jain, Mary O’Kelly Boit, Bowen Li, Hsiang-Chieh Hung, Sharon A. Creason, Jonathan Himmelfarb, Buddy D. Ratner, and Shaoyi Jiang American Chemical Society September 2, 2020 Medical-grade poly(vinyl chloride) (PVC) is commonly used in flexible medical products because of its transparency, strength, and affordability. Although toxicological, biological, and physiological testing of PVC products has deemed them safe, medical-grade PVC-based materials are criticized for high thrombin generation and complement...

Pooled Human AB Serum Off The Clot from Innovative Research was used in the following study:   Effects of Different Separation Methods on the Physical and Functional Properties of Extracellular Vesicles Hyungtaek Jeon, Su-Kyung Kang, Myung-Shin Lee PLoS ONE July 7, 2020 Extracellular vesicles (EVs) are nano-sized membrane vesicles (20–500 nm) of endocytic origin that are secreted by most cells under normal physiological conditions, as well as by cells undergoing pathological processes. EVs contain a variety of molecules such as proteins, nucleic acids, and lipids, which are affected by environmental factors and health conditions, making them potential biomarkers for diseases...

Pooled Human Complement Serum from Innovative Research was used in the following study:   Trimethylamine N-oxide–derived zwitterionic polymers: A new class of ultralow fouling bioinspired materials Bowen Li, Priyesh Jain, Jinrong Ma, Josh K. Smith, Zhefan Yuan, Hsiang-Chieh Hung, Yuwei He, Xiaojie Lin, Kan Wu, Jim Pfaendtner, and Shaoyi Jiang Science Advances 2019 Jun 14 ”…Materials that resist nonspecific protein adsorption are needed for many applications. However, few are able to achieve ultralow fouling in complex biological milieu. Zwitterionic polymers emerge as a class of highly effective ultralow fouling materials due to their superhydrophilicity, outperforming other hydrophilic materials such as...

Human Complement from Innovative Research was used in the following study:   CD55 upregulation in astrocytes by statins as potential therapy for AQP4-IgG seropositive neuromyelitis optica Lukmanee Tradtrantip, Tianjiao Duan, Michael R. Yeaman, Alan S. Verkman Journal of Neuroinflammation December 2019, 16:57 "... Neuromyelitis optica spectrum disorder (herein called NMO) is an inflammatory demyelinating disease that can be initiated by binding of immunoglobulin G autoantibodies (AQP4-IgG) to aquaporin-4 on astrocytes, causing complement-dependent cytotoxicity (CDC) and downstream inflammation. The increased NMO pathology in rodents deficient in complement regulator protein CD59 following passive transfer of AQP4-IgG has suggested the potential therapeutic utility...