Product References — Pooled Human Complement Serum

In the dynamic landscape of medical research, SAR443809 emerges as a promising candidate for the treatment of complement-mediated disorders. Complement-mediated disorders pose a significant challenge in healthcare, marked by the immune system erroneously targeting healthy cells. Central to these disorders is the complement alternative pathway, an integral part of our immune response. When dysregulated, it can precipitate severe and potentially fatal conditions. This groundbreaking study unveils the potential of a humanized IgG4 monoclonal antibody, specifically designed to selectively inhibit the complement alternative pathway, thereby opening new therapeutic avenues for patients globally. Key Insights from Recent Research SAR443809 distinguishes itself with...

Innovative Research is excited to share our top 5 biological products that are making waves in the scientific community right now. These products are designed to support your research and provide reliable, high-quality results. Cerebrospinal Fluid (CSF) Our Pooled Human Cerebrospinal Fluid (CSF) is an essential resource in neurology and neuroscience research and one of our current most popular products. Our CSF products are sourced as medical remnants and can be used for a variety of applications. Complement Serum Complement Serum is a vital component of the immune system and plays a crucial role in the body’s defense against infections. Taken from...

Single Donor Human Complement Serum from Innovative Research was used in the following study:   Cytoprotective IgG Antibodies in Sera from a Subset of Patients with AQP4‑IgG Seropositive Neuromyelitis Optica Spectrum Disorder LukmaneeTradtrantip, Michael R. Yeaman & A. S. Verkman Scientific Reports November 9, 2021 Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disorder that attacks the central nervous system and can cause demyelination in the optic nerve, spinal cord, and brain, and potentially cause further neurological deficits. Over 70% of patients suffering from NMOSD are seropositive for IgG autoantibodies which target extracellular epitopes of astrocyte water channel aquaporin-4 (AQP4),...

Pooled Human Complement Serum from Innovative Research was used in the following study:   Photoreactive Carboxybetaine Copolymers Impart Biocompatibility and Inhibit Plasticizer Leaching on Polyvinyl Chloride Xiaojie Lin, Kan Wu, Qiong Zhou, Priyesh Jain, Mary O’Kelly Boit, Bowen Li, Hsiang-Chieh Hung, Sharon A. Creason, Jonathan Himmelfarb, Buddy D. Ratner, and Shaoyi Jiang American Chemical Society September 2, 2020 Medical-grade poly(vinyl chloride) (PVC) is commonly used in flexible medical products because of its transparency, strength, and affordability. Although toxicological, biological, and physiological testing of PVC products has deemed them safe, medical-grade PVC-based materials are criticized for high thrombin generation and complement...

Pooled Human AB Serum Off The Clot from Innovative Research was used in the following study:   Effects of Different Separation Methods on the Physical and Functional Properties of Extracellular Vesicles Hyungtaek Jeon, Su-Kyung Kang, Myung-Shin Lee PLoS ONE July 7, 2020 Extracellular vesicles (EVs) are nano-sized membrane vesicles (20–500 nm) of endocytic origin that are secreted by most cells under normal physiological conditions, as well as by cells undergoing pathological processes. EVs contain a variety of molecules such as proteins, nucleic acids, and lipids, which are affected by environmental factors and health conditions, making them potential biomarkers for diseases...