News

PAI-1 Mutation in Amish Community Could Lead to New Treatments for Age-Related Disorders

A genetic mutation in SERPINE1, the gene responsible for Plasminogen Activator Inhibitor-1 (PAI-1), seems to have ties back to leading a longer, healthier life. While complete PAI-1 deficiency can lead to a life-threatening clotting disorder, individuals who were heterozygous for this mutation seem to enjoy an extended lifespan on average.

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The case for PAI-1 as a biomarker for major depressive disorder and antidepressant resistance

New research validates the PAI-1 knockout mouse as a preclinical genetic model of human depression, while demonstrating that this knockout also serves as a model for antidepressant resistance. Not only that, but this new research shows PAI-1 is involved in depression separately from the tPA-BDNF axis. As a result, PAI-1 could be a novel target for developing new treatments for major depressive disorder.

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Antigen, Abbreviated: Plasminogen Activator Inhibitor 1 (PAI-1)
Plasminogen Activator Inhibitor 1 (PAI-1) is a key component of fibrinolysis, the process by which the body is able to break apart a cross-linked fibrin clot. As an inhibitor of both tPA and uPA, PAI-1 is the primary inhibitor among the plasminogen activators and plays an important role in allowing appropriate clotting to occur. PAI-1 also plays a role in different conditions and diseases.

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Specialized Biologicals for Your Research
With such a large product catalog that spans so many different product types and product applications, Innovative Research has been working on creating meaningful collections that group together related products.

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Post-Doctorate Grant Opportunity to Fund Innovative Research in the Life Sciences
At Innovative Research, Inc. we fully believe in the importance of funding innovative research in the life sciences. To this end, we are offering a $10,000 grant for post-doctorate research in life science.

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