News

The case for PAI-1 as a biomarker for major depressive disorder and antidepressant resistance

New research validates the PAI-1 knockout mouse as a preclinical genetic model of human depression, while demonstrating that this knockout also serves as a model for antidepressant resistance. Not only that, but this new research shows PAI-1 is involved in depression separately from the tPA-BDNF axis. As a result, PAI-1 could be a novel target for developing new treatments for major depressive disorder.

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Antigen, Abbreviated: Plasminogen Activator Inhibitor 1 (PAI-1)
Plasminogen Activator Inhibitor 1 (PAI-1) is a key component of fibrinolysis, the process by which the body is able to break apart a cross-linked fibrin clot. As an inhibitor of both tPA and uPA, PAI-1 is the primary inhibitor among the plasminogen activators and plays an important role in allowing appropriate clotting to occur. PAI-1 also plays a role in different conditions and diseases.

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Specialized Biologicals for Your Research
With such a large product catalog that spans so many different product types and product applications, Innovative Research has been working on creating meaningful collections that group together related products.

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Post-Doctorate Grant Opportunity to Fund Innovative Research in the Life Sciences
At Innovative Research, Inc. we fully believe in the importance of funding innovative research in the life sciences. To this end, we are offering a $10,000 grant for post-doctorate research in life science.

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Taking the Time out of Testing with Paper Spray Mass Spectrometry

Innovative Research recently had the opportunity to talk to Dr. Trevor Glaros, researcher in the BioDefense Branch at the US Army CCDC Chemical Biological Center in Aberdeen, Maryland, about his research into combining paper spray ionization with the power of mass spectrometry analysis, a technique known as Paper Spray Mass Spectrometry (PS-MS), and how his research is leading to further applications for this technique.

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