Product References
Solid-Phase Microextraction Enables Isolation of BRAF V600E Circulating Tumor DNA from Human Plasma for Detection with a Molecular Beacon Loop-Mediated Isothermal Amplification Assay
Posted by Corey Marcath on
Pooled Human Plasma Apheresis Derived from Innovative Research was used in the following study: Solid-Phase Microextraction Enables Isolation of BRAF V600E Circulating Tumor DNA from Human Plasma for Detection with a Molecular Beacon Loop-Mediated Isothermal Amplification Assay Marcelino Varona, Derek R. Eitzmann, Darshna Pagariya, Robbyn K. Anand, and Jared L. Anderson Analytical Chemistry 17 Jan 2020 ”Circulating tumor DNA (ctDNA) is a promising biomarker that can provide a wealth of information regarding the genetic makeup of cancer as well as provide a guide for monitoring treatment. Methods for rapid and accurate profiling of ctDNA are highly desirable in order...
Bioanalysis of EGFRm inhibitor osimertinib, and its glutathione cycle- and desmethyl metabolites by liquid chromatography-tandem mass spectrometry
Posted by Corey Marcath on
Single Donor Human Plasma (Blood Derived) from Innovative Research was used in the following study: Bioanalysis of EGFRm inhibitor osimertinib, and its glutathione cycle- and desmethyl metabolites by liquid chromatography-tandem mass spectrometry J.J.M Rood, M.J.van Haren, J.H.Beijnen, R.W.Sparidans Journal of Pharmaceutical and Biomedical Analysis January 2020 “…Osimertinib is a “third-generation’’ oral, irreversible, tyrosine kinase inhibitor. It is used in the treatment of non-small cellular lung carcinoma and spares wild-type EGFR. Due to its reactive nature, osimertinib is, in addition to oxidative routes, metabolized through GSH coupling and subsequent further metabolism of these conjugates. The extent of the non-oxidative metabolism...
Isoform-specific promotion of breast cancer tumorigenicity by TBX3 involves induction of angiogenesis
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Sheep Red Blood Cells Packed 100% from Innovative Research was used in the following study: Isoform-specific promotion of breast cancer tumorigenicity by TBX3 involves induction of angiogenesis Milica Krstic, Haider M. Hassan, Bart Kolendowski, M. Nicole Hague, Pieter. H. Anborgh, Carl O. Postenka, Joseph Torchia, Ann F. Chambers & Alan B. Tuck Laboratory Investigation 30 September 2019 “TBX3 is a member of the highly conserved family of T-box transcription factors involved in embryogenesis, organogenesis and tumor progression. While the functional role of TBX3 in tumorigenesis has been widely studied, less is known about the specific functions of the different...
An inherent T cell deficit in healthy males to C. neoformans infection may begin to explain the sex susceptibility in incidence of cryptococcosis
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Pooled Human Serum Off The Clot from Innovative Research was used in the following study: An inherent T cell deficit in healthy males to C. neoformans infection may begin to explain the sex susceptibility in incidence of cryptococcosis Tiffany E. Guess, Joseph Rosen, Natalia Castro-Lopez, Floyd L. Wormley Jr, Erin E. McClelland Biology of Sex Differences 02 September 2019 “…Cryptococcus neoformans is responsible for an estimated 220,000 cases of cryptococcosis, resulting in more than 181,000 deaths each year worldwide. An opportunistic fungal pathogen, C. neoformans typically presents as pneumonia or meningitis, the latter of which is considered an AIDS-defining...
Preparation and characterization of biodegradable and hemocompatible copolymers
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Single Donor Human Whole Blood from Innovative Research was used in the following study: Preparation and characterization of biodegradable and hemocompatible copolymers Ji Hoon Park, Seung Hun Park, Joon Yeong Park, Hyeon Jin Ju, Yun Bae Ji, Jae Ho Kim, Byoung Hyun Min, Moon Suk Kim Reactive and Functional Polymers 31 October 2019 “…In this study, we developed biodegradable polyesters with hemocompatibility and anti-thrombotic functions. First, we synthesized 3-benzyloxymethyl-6-methyl-1,4-dioxane-2,5-dione (LA-Bz). The ring opening polymerization of ε-caprolactone (CL), L-lactide (LA), and LA-Bz monomers provided poly(ε-caprolactone-ran-L-lactide-ran-3-benzyloxymethyl lactide) (PCLA-Bz) copolymers. Poly(ε-caprolactone-ran-L-lactide) (PCLA) was prepared as a control biodegradable copolymer. …and single donor...