Product References
Interaction of Pregnancy-Specific Glycoprotein 1 With Integrin α5β1 Is a Modulator of Extravillous Trophoblast Functions
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Innovative Grade US Origin Fetal Bovine Serum from Innovative Research was used in the following study: Interaction of Pregnancy-Specific Glycoprotein 1 With Integrin α5β1 Is a Modulator of Extravillous Trophoblast Functions Shemona Rattila, Caroline E. Dunk , Michelle Im, Olga Grichenko, Yan Zhou 4, Marie Cohen 5, Maria Yanez-Mo, Sandra M. Blois, Kenneth M. Yamada, Offer Erez, Nardhy Gomez-Lopez, Stephen J. Lye, Boris Hinz, Roberto Romero, Gabriela Dveksler MDPI 31 October 2019 “…Pregnancy-specific glycoproteins (PSGs), also known as Schwangerschafts Protein 1 (SP1) and pregnancy-specific beta 1 glycoproteins, are secreted placental proteins found in the maternal circulation [1–4]. PSGs belong...
Cathelicidin Peptides Restrict Bacterial Growth via Membrane Perturbation and Induction of Reactive Oxygen Species
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Single Donor Human Red Blood Cells from Innovative Research was used in the following study: Cathelicidin Peptides Restrict Bacterial Growth via Membrane Perturbation and Induction of Reactive Oxygen Species Dean A. Rowe-Magnus, Adenine Y. Kao, Antonio Cembellin Prieto, Meng Pu, Cheng Kao American Society for Microbiology 10 September 2019 ”… All metazoans produce antimicrobial peptides (AMPs) that have both broad antimicrobial and immunomodulatory activity. Cathelicidins are AMPs that preferentially kill Gram-negative bacteria in vitro, purportedly by assembling into higher-order structures that perforate the membrane. We utilized high-resolution, single-cell fluorescence microscopy to examine their mechanism of action in real time....
Solid-Phase Microextraction Enables Isolation of BRAF V600E Circulating Tumor DNA from Human Plasma for Detection with a Molecular Beacon Loop-Mediated Isothermal Amplification Assay
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Pooled Human Plasma Apheresis Derived from Innovative Research was used in the following study: Solid-Phase Microextraction Enables Isolation of BRAF V600E Circulating Tumor DNA from Human Plasma for Detection with a Molecular Beacon Loop-Mediated Isothermal Amplification Assay Marcelino Varona, Derek R. Eitzmann, Darshna Pagariya, Robbyn K. Anand, and Jared L. Anderson Analytical Chemistry 17 Jan 2020 ”Circulating tumor DNA (ctDNA) is a promising biomarker that can provide a wealth of information regarding the genetic makeup of cancer as well as provide a guide for monitoring treatment. Methods for rapid and accurate profiling of ctDNA are highly desirable in order...
Bioanalysis of EGFRm inhibitor osimertinib, and its glutathione cycle- and desmethyl metabolites by liquid chromatography-tandem mass spectrometry
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Single Donor Human Plasma (Blood Derived) from Innovative Research was used in the following study: Bioanalysis of EGFRm inhibitor osimertinib, and its glutathione cycle- and desmethyl metabolites by liquid chromatography-tandem mass spectrometry J.J.M Rood, M.J.van Haren, J.H.Beijnen, R.W.Sparidans Journal of Pharmaceutical and Biomedical Analysis January 2020 “…Osimertinib is a “third-generation’’ oral, irreversible, tyrosine kinase inhibitor. It is used in the treatment of non-small cellular lung carcinoma and spares wild-type EGFR. Due to its reactive nature, osimertinib is, in addition to oxidative routes, metabolized through GSH coupling and subsequent further metabolism of these conjugates. The extent of the non-oxidative metabolism...
Isoform-specific promotion of breast cancer tumorigenicity by TBX3 involves induction of angiogenesis
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Sheep Red Blood Cells Packed 100% from Innovative Research was used in the following study: Isoform-specific promotion of breast cancer tumorigenicity by TBX3 involves induction of angiogenesis Milica Krstic, Haider M. Hassan, Bart Kolendowski, M. Nicole Hague, Pieter. H. Anborgh, Carl O. Postenka, Joseph Torchia, Ann F. Chambers & Alan B. Tuck Laboratory Investigation 30 September 2019 “TBX3 is a member of the highly conserved family of T-box transcription factors involved in embryogenesis, organogenesis and tumor progression. While the functional role of TBX3 in tumorigenesis has been widely studied, less is known about the specific functions of the different...