News — academic research

A series of sudden and unexplained deaths among seemingly healthy Amish children has been a mystery for years. New technology has allowed researchers to isolate the rare genetic mutation in the RYR2 gene that is to blame, offering answers and hope to the families impacted.

A genetic mutation in SERPINE1, the gene responsible for Plasminogen Activator Inhibitor-1 (PAI-1), seems to have ties back to leading a longer, healthier life. While complete PAI-1 deficiency can lead to a life-threatening clotting disorder, individuals who were heterozygous for this mutation seem to enjoy an extended lifespan on average.

New research validates the PAI-1 knockout mouse as a preclinical genetic model of human depression, while demonstrating that this knockout also serves as a model for antidepressant resistance. Not only that, but this new research shows PAI-1 is involved in depression separately from the tPA-BDNF axis. As a result, PAI-1 could be a novel target for developing new treatments for major depressive disorder.

At Innovative Research, Inc. we fully believe in the importance of funding innovative research in the life sciences. To this end, we are offering a $10,000 grant for post-doctorate research in life science.

To help support all of the exciting research happening at the various universities and colleges we partner with, we're introducing a Back to School special offer as a way for us to get to know you, and for you to get to know us! Supporting the researchers of tomorrow is a passion of Innovative Research, and we want to partner with more teams doing groundbreaking work throughout your institution.