Product References — Innovative Grade US Origin Rat Sprague Dawley Plasma

Development and validation of a UHPLC-MS/MS method to determine the bioavailability of warfarin and its major metabolite 7-hydroxy warfarin in rats dosed with oral formulations containing different polymorphic forms

Posted by Corey Marcath on

Development and validation of a UHPLC-MS/MS method to determine the bioavailability of warfarin and its major metabolite 7-hydroxy warfarin in rats dosed with oral formulations containing different polymorphic forms

Innovative Grade US Origin Rat Sprague Dawley Plasma from Innovative Research was used in the following study:   Development and validation of a UHPLC-MS/MS method to determine the bioavailability of warfarin and its major metabolite 7-hydroxy warfarin in rats dosed with oral formulations containing different polymorphic forms Diaa Shakleya, Ziyaur Rahman, Patrick J. Faustino Biomedical Chromatography 20 August 2019 “…A simple, sensitive and rapid UHPLC-ESI-MS/MS method was developed and validated for the quantification of warfarin and 7-hydroxy warfarin in SD rats… Blank rat plasma was purchased from Innovative Research Inc…”   Related products available from Innovative Research also include: Innovative...

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A novel high-performance liquid chromatographic method combined with fluorescence detection for determination of ertugliflozin in rat plasma: Assessment of pharmacokinetic drug interaction potential of ertugliflozin with mefenamic acid and ketoconazole

Posted by Corey Marcath on

A novel high-performance liquid chromatographic method combined with fluorescence detection for determination of ertugliflozin in rat plasma: Assessment of pharmacokinetic drug interaction potential of ertugliflozin with mefenamic acid and ketoconazole

Innovative Grade US Origin Rat Sprague Dawley Plasma from Innovative Research was used in the following study:   A novel high-performance liquid chromatographic method combined with fluorescence detection for determination of ertugliflozin in rat plasma: Assessment of pharmacokinetic drug interaction potential of ertugliflozin with mefenamic acid and ketoconazole Dong-Gyun Han, Hwayoung Yun, In-Soo Yoon Journal of Chromatography B 25 May 2019 “…Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by insulin resistance and the inability of the body to secrete sufficient insulin, resulting in high blood glucose levels [1]. A recent survey estimated that T2DM affected 415 million...

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Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound

Posted by Leanne Kodsmann on

Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound

Mouse CD1 Plasma, Rat Plasma, and Pooled Human Plasma from Innovative Research were used in the following study:   Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound Lara Pes, Stephan David Koester, Johannes Pall Magnusson, Serghei Chercheja, Federico Medda, Khalid Abu Ajaj, Didier Rognan, Steffen Daum, Friederike Inga Nollmann, Javier Garcia Fernandez, Patricia Perez Galan, Heidi-Kristin Walter, Anna Warnecke, Felix Kratz Journal of Controlled Release Volume 296, 28 February 2019, Pages 81-92 "... AE-KetoSulf07 and AE-Ester-Sulf07 are novel acid-sensitive albumin-binding prodrugs demonstrating tumor regressions in all of the evaluated human tumor xenograft...

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Plasma ameliorates endothelial dysfunction in burn injury

Posted by Leanne Kodsman on

Sprague Dawley Rat Plasma from Innovative Research was recently used in the following study: Plasma ameliorates endothelial dysfunction in burn injuryMariana Vigiola Cruz MD, Bonnie C. Carney BS, Jenna N. Luker MD, Kyle W. Monger BS, Juan Sebastian Vazquez MD, Lauren T. Moffatt PhD, Laura S. Johnson MD, Jeffrey W. Shupp MD Journal of Surgical Research, January 2019 " ... Sprague-Dawley rats were used to create small, medium, and large burns and uninjured controls. Three different intravenous resuscitation protocols were applied within each group: Lactated Ringer's (LR) alone, LR plus fresh frozen plasma (FFP), or LR plus albumin... In the...

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Simultaneous measurement of folate cycle intermediates in different biological matrices using liquid chromatography-tandem mass spectrometry

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Rat Plasma from Innovative Research was recently used in the following study: Simultaneous measurement of folate cycle intermediates in different biological matrices using liquid chromatography-tandem mass spectrometryJatin Nandania, Meri Kokkonen, Liliya Euro, Vidya Velagapudi Journal of Chromatography B: Volume 1092, 15 August 2018, Pages 168-178 ... Rat plasma with heparin as the anticoagulant was purchased from Innovative Research Laboratory (Novi, MI, USA). Whole Human Whole Blood was procured from the ... Related products available from Innovative Research also include: Innovative Grade US Origin Sprague Dawley Rat Plasma Innovative Grade US Origin Wistar Rat Plasma Rat Latent PAI-1 Depleted Plasma, Sodium...

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