Product References — Innovative Grade US Origin Rat Sprague Dawley Plasma

Sensitive and Rapid UHPLC–MS/MS Assay for Simultaneous Quantifications of Calcipotriol and Paclitaxel in Rat Whole Blood and Plasma Samples

Posted by Adam Awdish on

Sensitive and Rapid UHPLC–MS/MS Assay for Simultaneous Quantifications of Calcipotriol and Paclitaxel in Rat Whole Blood and Plasma Samples

Innovative Grade US Origin Rat Sprague Dawley Whole Blood and Innovative Grade US Origin Rat Sprague Dawley Plasma from Innovative Research was used in the following study:   Sensitive and Rapid UHPLC–MS/MS Assay for Simultaneous Quantifications of Calcipotriol and Paclitaxel in Rat Whole Blood and Plasma Samples Victor R. Lincha, Cheng-Hui Hsiao, Jun Zhao, Chun Li, Diana S-L Chow Journal of Pharmaceutical and Biomedical Analysis October 9, 2020 The potential benefits of stroma-depleting agents combined with chemotherapy for pancreatic ductal adenocarcinoma (PDAC) treatment has been examined in vitro and in transplantation studies. Unfortunately, this type of treatment has failed in...

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Statistical optimization and validation of a novel ultra-performance liquid chromatography method for estimation of nintedanib in rat and human plasma

Posted by Corey Marcath on

Statistical optimization and validation of a novel ultra-performance liquid chromatography method for estimation of nintedanib in rat and human plasma

Single Donor Human Plasma (Blood Derived) and Innovative Grade US Origin Rat Sprague Dawley Single Donor Plasma from Innovative Research was used in the following study:   Statistical optimization and validation of a novel ultra-performance liquid chromatography method for estimation of nintedanib in rat and human plasma Snehal K Shukla, Hossam Kadry, Jayshil A Bhatt, Rasha Elbatanony, Fakhrul Ahsan & Vivek Gupta Future Science 13 Feb 2020 “A high throughput ultra-performance liquid chromatography (UPLC)-ultraviolet method for quantification of nintedanib in rat and human plasma was developed and optimized using chemometrical approach… Rat plasma and human plasma were acquired from Innovative...

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Development and validation of a UHPLC-MS/MS method to determine the bioavailability of warfarin and its major metabolite 7-hydroxy warfarin in rats dosed with oral formulations containing different polymorphic forms

Posted by Corey Marcath on

Development and validation of a UHPLC-MS/MS method to determine the bioavailability of warfarin and its major metabolite 7-hydroxy warfarin in rats dosed with oral formulations containing different polymorphic forms

Innovative Grade US Origin Rat Sprague Dawley Plasma from Innovative Research was used in the following study:   Development and validation of a UHPLC-MS/MS method to determine the bioavailability of warfarin and its major metabolite 7-hydroxy warfarin in rats dosed with oral formulations containing different polymorphic forms Diaa Shakleya, Ziyaur Rahman, Patrick J. Faustino Biomedical Chromatography 20 August 2019 “…A simple, sensitive and rapid UHPLC-ESI-MS/MS method was developed and validated for the quantification of warfarin and 7-hydroxy warfarin in SD rats… Blank rat plasma was purchased from Innovative Research Inc…”   Related products available from Innovative Research also include: Innovative...

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A novel high-performance liquid chromatographic method combined with fluorescence detection for determination of ertugliflozin in rat plasma: Assessment of pharmacokinetic drug interaction potential of ertugliflozin with mefenamic acid and ketoconazole

Posted by Corey Marcath on

A novel high-performance liquid chromatographic method combined with fluorescence detection for determination of ertugliflozin in rat plasma: Assessment of pharmacokinetic drug interaction potential of ertugliflozin with mefenamic acid and ketoconazole

Innovative Grade US Origin Rat Sprague Dawley Plasma from Innovative Research was used in the following study:   A novel high-performance liquid chromatographic method combined with fluorescence detection for determination of ertugliflozin in rat plasma: Assessment of pharmacokinetic drug interaction potential of ertugliflozin with mefenamic acid and ketoconazole Dong-Gyun Han, Hwayoung Yun, In-Soo Yoon Journal of Chromatography B 25 May 2019 “…Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by insulin resistance and the inability of the body to secrete sufficient insulin, resulting in high blood glucose levels [1]. A recent survey estimated that T2DM affected 415 million...

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Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound

Posted by Leanne Kodsmann on

Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound

Mouse CD1 Plasma, Rat Plasma, and Pooled Human Plasma from Innovative Research were used in the following study:   Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound Lara Pes, Stephan David Koester, Johannes Pall Magnusson, Serghei Chercheja, Federico Medda, Khalid Abu Ajaj, Didier Rognan, Steffen Daum, Friederike Inga Nollmann, Javier Garcia Fernandez, Patricia Perez Galan, Heidi-Kristin Walter, Anna Warnecke, Felix Kratz Journal of Controlled Release Volume 296, 28 February 2019, Pages 81-92 "... AE-KetoSulf07 and AE-Ester-Sulf07 are novel acid-sensitive albumin-binding prodrugs demonstrating tumor regressions in all of the evaluated human tumor xenograft...

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