Product References — Pooled Human Plasma Apheresis Derived

Quantification of U-47700 and its metabolites in plasma by LC-MS/MS

Posted by Leanne Kodsmann on

Quantification of U-47700 and its metabolites in plasma by LC-MS/MS

Pooled Human Plasma Apheresis Derived from Innovative Research was used in the following study:   Quantification of U-47700 and its metabolites in plasma by LC-MS/MS Christina R. Smith, Michael T. Truver, Madeleine J. Swortwood Journal of Chromatography B Volume 1112, 1 April 2019, Pages 41-47 "... Novel Synthetic Opioids (NSO) have caused a recent epidemic both nationally and globally. NSO have gained popularity in the illicit drug market and have brought about an increase in fentanyl and its derivatives, as well as other chemically unrelated opioid agonists. U-47700, a non-fentanyl analog analgesic opioid, was first developed by The Upjohn Company...

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Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound

Posted by Leanne Kodsmann on

Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound

Mouse CD1 Plasma, Rat Plasma, and Pooled Human Plasma from Innovative Research were used in the following study:   Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound Lara Pes, Stephan David Koester, Johannes Pall Magnusson, Serghei Chercheja, Federico Medda, Khalid Abu Ajaj, Didier Rognan, Steffen Daum, Friederike Inga Nollmann, Javier Garcia Fernandez, Patricia Perez Galan, Heidi-Kristin Walter, Anna Warnecke, Felix Kratz Journal of Controlled Release Volume 296, 28 February 2019, Pages 81-92 "... AE-KetoSulf07 and AE-Ester-Sulf07 are novel acid-sensitive albumin-binding prodrugs demonstrating tumor regressions in all of the evaluated human tumor xenograft...

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Determination of total and unbound ribociclib in human plasma and brain tumor tissues using liquid chromatography coupled with tandem mass spectrometry

Posted by Leanne Kodsmann on

Determination of total and unbound ribociclib in human plasma and brain tumor tissues using liquid chromatography coupled with tandem mass spectrometry

Single Donor Human Plasma from Innovative Research was used in the following study:   Determination of total and unbound ribociclib in human plasma and brain tumor tissues using liquid chromatography coupled with tandem mass spectrometry Xun Bao, Jianmei Wu, Nader Sanai, Jing Li Journal of Pharmaceutical and Biomedical Analysis Volume 166, 20 March 2019, Pages 197-204 "... Drug-free (blank) human plasma from six different healthy donors and pooled plasma (with Na-EDTA anticoagulant) were purchased from Innovative Research Inc. (Novi, MI, USA) ... Frozen plasma and tumor samples were thawed at room temperature. Patient plasma samples were diluted 5-fold with blank...

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HIV Integrase Inhibitor Pharmacogenetics: An Exploratory Study

Posted by Leanne Kodsmann on

HIV Integrase Inhibitor Pharmacogenetics: An Exploratory Study

Human Plasma from Innovative Research was used in the following study:   HIV Integrase Inhibitor Pharmacogenetics: An Exploratory Study Derek E. Murrell, David B. Cluck, Jonathan P. Moorman, Stacy D. Brown, Ke-Sheng Wang, Michelle M. Duffourc, Sam Harirforoosh Clinical Drug Investigation March 2019, Volume 39, Issue 3, pp 285–299 "... Plasma, for pharmacokinetic analysis, and remaining cells, for genetic testing, were separated then placed at −80 °C until analysis. Samples were analyzed using a previously validated liquid chromatography-mass spectrometry (LC–MS) assay developed by Simiele et al., with modifcations [25]. Briefy, a standard curve ranging from 10 ng/ml to 1500 ng/ml...

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Ultrasensitive multi-species detection of CRISPR-Cas9 by a portable centrifugal microfluidic platform

Posted by Leanne Kodsmann on

Ultrasensitive multi-species detection of CRISPR-Cas9 by a portable centrifugal microfluidic platform

Human Whole Blood, Pooled Human Serum, and Pooled Human Plasma from Innovative Research were used in the following study:   Ultrasensitive multi-species detection of CRISPR-Cas9 by a portable centrifugal microfluidic platform Christopher R. Phaneuf, Kyle J. Seamon, Tyler P. Eckles, Anchal Sinha, Joseph S. Schoeniger, Brooke Harmon, Robert J. Meagher, Vinay V. Abhyankar and Chung-Yan Koh Analytical Methods Issue 5, 2019 "... The potential for accidental exposure, malicious use, or undesirable persistence of Cas9 therapeutics and off-target genome effects highlight the need for detection assays. Here we report a centrifugal microfluidic platform for the measurement of both Cas9 protein levels and nuclease...

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