Product References — Pooled Human Plasma Apheresis Derived

A Systematic Study of the In Vitro Pharmacokinetics and Estimated Human In Vivo Clearance of Indole and Indazole-3-Carboxamide Synthetic Cannabinoid Receptor Agonists Detected on the Illicit Drug Market

Posted by Adam Awdish on

A Systematic Study of the In Vitro Pharmacokinetics and Estimated Human In Vivo Clearance of Indole and Indazole-3-Carboxamide Synthetic Cannabinoid Receptor Agonists Detected on the Illicit Drug Market

Pooled Human Plasma Apheresis Derived from Innovative Research was used in the following study:   A Systematic Study of the In Vitro Pharmacokinetics and Estimated Human In Vivo Clearance of Indole and Indazole-3-Carboxamide Synthetic Cannabinoid Receptor Agonists Detected on the Illicit Drug Market Andrew M. Brandon, Lysbeth H. Antonides, Jennifer Riley, Ola Epemolu, Denise A. McKeown, Kevin D. Read, and Craig McKenzie Molecules March 5, 2021 A new, diverse group of synthetic drugs designed to activate human cannabinoid receptors CB1 and CB2 have emerged in the illicit drug market over recent years. These synthetic cannabinoid receptor agonists (SCRAs) have been...

Read more →

Can Remdesivir and its Parent Nucleoside GS-441524 be Potential Oral Drugs? An in vitro and in vivo DMPK Assessment

Posted by Adam Awdish on

Can Remdesivir and its Parent Nucleoside GS-441524 be Potential Oral Drugs? An in vitro and in vivo DMPK Assessment

Innovative Grade US Origin Mouse CD1 Plasma and Pooled Human Plasma Apheresis Derived from Innovative Research were used in the following study:   Can Remdesivir and its Parent Nucleoside GS-441524 be Potential Oral Drugs? An in vitro and in vivo DMPK Assessment Jiashu Xie, Zhengqiang Wang Acta Pharmaceutica Sinica B March 5, 2021 To date, the only FDA-approved drug for treating COVID-19 is Remdesivir (RDV), which can only be administered intravenously. RDV is a ProTide drug derived from nucleoside GS-441524, and the potency of RDV is dependent on intracellular conversion into GS-441524 triphosphate. In vitro studies of RDV in human...

Read more →

Metabolism of a Kratom Alkaloid Metabolite in Human Plasma Increases Its Opioid Potency and Efficacy

Posted by Adam Awdish on

Metabolism of a Kratom Alkaloid Metabolite in Human Plasma Increases Its Opioid Potency and Efficacy

Mouse Non-Swiss Albino Plasma and Pooled Human Plasma Apheresis Derived from Innovative Research were used in the following study:   Metabolism of a Kratom Alkaloid Metabolite in Human Plasma Increases Its Opioid Potency and Efficacy Shyam H. Kamble, Francisco León, Tamara I. King, Erin C. Berthold, Carolina Lopera-Londoño, Kanumuri Siva Rama Raju, Aidan J. Hampson, Abhisheak Sharma, Bonnie A. Avery, Lance R. McMahon, and Christopher R. McCurdy ACS Pharmacology & Translational Science July 31, 2020 Kratom is commonly used in the United States for self-treatment of pain and opioid withdrawal symptoms. Mitragynine is the most abundant alkaloid in kratom, and...

Read more →

Evaluating the Quantity, Quality and Size Distribution of Cell-Free DNA by Multiplex Droplet Digital PCR

Posted by Adam Awdish on

Evaluating the Quantity, Quality and Size Distribution of Cell-Free DNA by Multiplex Droplet Digital PCR

Pooled Human Plasma Apheresis Derived from Innovative Research was used in the following study:   Evaluating the Quantity, Quality and Size Distribution of Cell-Free DNA by Multiplex Droplet Digital PCR Miguel Alcaide, Matthew Cheung, Jack Hillman, S. Rod Rassekh, Rebecca J. Deyell, Gerald Batist, Aly Karsan, Alexander W. Wyatt, Nathalie Johnson, David W. Scott & Ryan D. Morin Scientific Reports July 28, 2020 Since their initial description in 1948, small DNA fragments travelling outside the cells in internal bodily fluids and excretions have revolutionized numerous fields in public health and preventive medicine. Cell-free DNA (cfDNA) is generally thought to arise...

Read more →

LC-MS/MS analysis of plasma glucosylsphingosine as a biomarker for diagnosis and follow-up monitoring in Gaucher disease in the Spanish population

Posted by Corey Marcath on

LC-MS/MS analysis of plasma glucosylsphingosine as a biomarker for diagnosis and follow-up monitoring in Gaucher disease in the Spanish population

Pooled Human Plasma Apheresis Derived from Innovative Research was used in the following study:   LC-MS/MS analysis of plasma glucosylsphingosine as a biomarker for diagnosis and follow-up monitoring in Gaucher disease in the Spanish population Pilar Irún, Jorge J. Cebolla, Laura López de Frutos, Isabel De Castro-Orós, Mercedes Roca-Espiau and Pilar Giraldo Clinical Chemistry and Laboratory Medicine (CCLM) February 3, 2020 The method was validated according to the guidelines of the US Food and Drug administration [33]. Briefly, matrix effects were assessed by analyzing five repetitions of a mixture of IS and ES in methanol and also spiking the same...

Read more →


×