Product References — Rat Sprague Dawley Plasma

Oligo(Lactic Acid)8-Rapamycin Prodrug-Loaded Poly(Ethylene Glycol)-block-Poly(Lactic Acid) Micelles for Injection

Posted by Corey Marcath on

Oligo(Lactic Acid)8-Rapamycin Prodrug-Loaded Poly(Ethylene Glycol)-block-Poly(Lactic Acid) Micelles for Injection

Rat Sprague Dawley Plasma from Innovative Research was used in the following study:   Oligo(Lactic Acid)8-Rapamycin Prodrug-Loaded Poly(Ethylene Glycol)-block-Poly(Lactic Acid) Micelles for Injection Yu Tong Tam, Lauren Repp, Zhi-Xiong Ma, John B. Feltenberger, Glen S. Kwon Springer US 19 March 2019 ”…The mammalian target of rapamycin (mTOR) is part of an elaborate intracellular signaling network that is commonly dysregulated in human tumors, making it an attractive substrate for targeted anticancer therapies. Downstream from the PI3K/ AKT signaling pathway, mTOR plays a key role in cell growth, cell proliferation and angiogenesis. …Heparinized Sprague-Dawley rat plasma was purchased from Innovative Research Inc....

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Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound

Posted by Leanne Kodsmann on

Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound

Mouse CD1 Plasma, Rat Plasma, and Pooled Human Plasma from Innovative Research were used in the following study:   Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound Lara Pes, Stephan David Koester, Johannes Pall Magnusson, Serghei Chercheja, Federico Medda, Khalid Abu Ajaj, Didier Rognan, Steffen Daum, Friederike Inga Nollmann, Javier Garcia Fernandez, Patricia Perez Galan, Heidi-Kristin Walter, Anna Warnecke, Felix Kratz Journal of Controlled Release Volume 296, 28 February 2019, Pages 81-92 "... AE-KetoSulf07 and AE-Ester-Sulf07 are novel acid-sensitive albumin-binding prodrugs demonstrating tumor regressions in all of the evaluated human tumor xenograft...

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Sprague Dawley Rat Plasma Reference 7-31-13

Posted by Leanne Kodsman on

Innovative Research's Sprague Dawley Rat Plasma was recently used in the following study: Effects of short-term portacaval anastomosis on the peripheral and brain disposition of the blood-brain barrier permeability marker sodium fluorescein in rats IH Shaik, MK Miah, U Bickel, R Mehvar - Brain Research, 2013...The effects of various bile acids on the f u of FL in plasma were investigated in an in vitro study. Drug-free, heparinized rat plasma (Innovative Research, Novi, MI) was spiked with LCA, CA, CDCA, or TCA at concentrations of 0, 18.75, 37.5, 75, or 150 M.

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Sprague Dawley Rat Plasma Reference 3-2010

Posted by Leanne Kodsman on

Innovative Research's Sprague Dawley Rat Plasma was recently used in the following study: Pharmacokinetics and metabolism of (R, R)-methoxyfenoterol in ratD Siluk, DE Mager, HS Kim, Y Wang... - ..., 2010 - informahealthcare.com...Pittsburgh, PA, USA). Purified water was prepared using a Milli-Q system (Millipore, Milford, MA, USA). Control rat plasma and urine were purchased from Innovative Research (Novi, MI, USA). Waymouth 752 culture medium...

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Sprague Dawley Rat Plasma Reference 12-28-10

Posted by Leanne Kodsman on

Innovative Research's Sprague Dawley Rat Plasma was recently used in the following study: Quantitative analysis of tissue folate using ultra high-performance liquid chromatography tandem mass spectrometryJ Liu, R Pickford, AP Meagher, RL Ward - Analytical Biochemistry, 2011 - Elsevier...In the labeled standards, the 13 C 5 was present in the five carbons of the glutamate moiety (isotopic enrichment >99%). Rat plasma from Innovative Research (Novi, MI, USA) was used as a source of conjugase to hydrolyze folate polyglutamates.

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