Product References — Innovative Grade US Origin Canine Beagle Plasma

Ultra-sensitive quantification of the therapeutic cyclic peptide bremelanotide utilizing UHPLC-MS/MS for evaluation of its oral plasma pharmacokinetics

Posted by Corey Marcath on

Ultra-sensitive quantification of the therapeutic cyclic peptide bremelanotide utilizing UHPLC-MS/MS for evaluation of its oral plasma pharmacokinetics

Innovative Grade US Origin Canine Beagle Plasma from Innovative Research was used in the following study:   Ultra-sensitive quantification of the therapeutic cyclic peptide bremelanotide utilizing UHPLC-MS/MS for evaluation of its oral plasma pharmacokinetics Max Sauter, Philipp Uhl, Jürgen Burhenne, Walter E.Haefeli Journal of Pharmaceutical and Biomedical Analysis 27 March 2020 Bremelanotide (Vyleesi®) is an -melanocyte-stimulating hormone analog that was recently approved for the treatment of premenopausal hypoactive sexual desire disorder (HSDD; [1]). It is a cyclic heptapeptide (sequence: Ac-Nle-cyclo[Asp-His-d-PheArg-Trp-Lys]−OH) that is cyclized via amide bonding of the side chain carboxy-function of Asp to the amino group of the side...

Read more →

An ultra-sensitive UHPLC-MS/MS assay for the quantification of orally administered vancomycin in plasma

Posted by Corey Marcath on

An ultra-sensitive UHPLC-MS/MS assay for the quantification of orally administered vancomycin in plasma

Innovative Grade US Origin Canine Beagle Plasma from Innovative Research was used in the following study:   An ultra-sensitive UHPLC-MS/MS assay for the quantification of orally administered vancomycin in plasma Max Sauter, Philipp Uhl, Kathrin I. Foerster, Isabelle Mohr, Rahel T. Hönec, Uta Merlec, Jürgen Burhenne, Walter E. Haefeli Journal of Pharmaceutical and Biomedical Analysis 27 June 2019 “…Vancomycin is a glyco-peptide antibiotic used intravenously for the treatment of gram-positive bacteria including multi-resistant Staphylococcus aureus and, as oral capsules, for the first-line treatment of gastro-intestinal Clostridium difficile infections (CDI). …Blank beagle plasma was purchased from Innovative Research (Novi, MI, USA)…”...

Read more →

Innovative Grade US Origin Beagle Plasma Reference 2-24-15

Posted by Leanne Kodsman on

Innovative Research's Innovative Grade US Origin Beagle Plasma was recently used in the following study: Species-Dependent Chelation of 241Am by DTPA Di-Ethyl EsterJE Huckle, MP Sadgrove, RJ Mumper, M Jay - Health Physics, 2015...separation. The 241 Am(NO 3 ) 3 stock solution was obtained from Eckert & Ziegler Isotope Products (Valencia, CA, USA). Rat, beagle and human plasma were obtained from Innovative Research Inc. (Novi, MI, USA). Pierce...

Read more →

Innovative Grade US Origin Beagle Plasma Reference 2-20-12

Posted by Leanne Kodsman on

Innovative Research's Innovative Grade US Origin Beagle Plasma was recently used in the following study: Implications of plasma protein binding for pharmacokinetics and pharmacodynamics of the gamma-secretase inhibitor RO4929097J Wu, PM LoRusso, LH Matherly... - Clinical Cancer Research, 2012 - AACRbr>...Louis, MO). Human, rat, mouse, and beagle plasma, and Human Whole Blood were obtained from Innovative Research Inc. (Novi, MI). pGL3-Basic vector, pRL-SV40 expression construct, and the dual- luciferase reporter assay system were obtained from Promega (Madison, WI).

Read more →