Product References — Innovative Grade US Origin Canine Beagle Plasma

Innovative Grade US Origin Canine Beagle Single Donor Plasma from Innovative Research was used in the following study:   Application of Triple Quadrupole Tandem Mass Spectrometry to the Bioanalysis of Collision-Induced Dissociation-Resistant Cyclic Peptides – Ultra-Sensitive Quantification of the Somatostatin-Analog Pasireotide Utilizing UHPLC-MS/MS Max Sauter, Philipp Uhl, Jürgen Burhenne, Walter E. Haefeli Journal of Pharmaceutical and Biomedical Analysis February 5, 2021 Peptides are short chains of amino acids that are highly specific and are typically not rejected by host bodies, making them promising candidates in therapeutic drug development. Typical peptides are unfortunately vulnerable to enzymatic hydrolysis, and therefore sequences of...

Innovative Grade US Origin Canine Beagle Plasma from Innovative Research was used in the following study:   Post-Extraction Disulfide Bond Cleavage for MS/MS Quantification of Collision-Induced Dissociation-Resistant Cystine-Cyclized Peptides and its Application to the Ultra-Sensitive UPLC-MS/MS Bioanalysis of Octreotide in Plasma Max Sauter, Philipp Uhl, Jürgen Burhenne, Walter E. Haefeli Analytica Chimica Acta April 10, 2020 Peptides are gaining importance in therapeutics due to their biocompatibility and chemical diversity. However, linear peptides are prone to degradation. Cyclic peptides, in contrast, have significant advantages over linear peptides, especially if the peptides are small. Cyclic peptides are usually resistant to collision-induced dissociation...

Innovative Grade US Origin Canine Beagle Plasma from Innovative Research was used in the following study:   Ultra-sensitive quantification of the therapeutic cyclic peptide bremelanotide utilizing UHPLC-MS/MS for evaluation of its oral plasma pharmacokinetics Max Sauter, Philipp Uhl, Jürgen Burhenne, Walter E.Haefeli Journal of Pharmaceutical and Biomedical Analysis 27 March 2020 Bremelanotide (Vyleesi®) is an -melanocyte-stimulating hormone analog that was recently approved for the treatment of premenopausal hypoactive sexual desire disorder (HSDD; [1]). It is a cyclic heptapeptide (sequence: Ac-Nle-cyclo[Asp-His-d-PheArg-Trp-Lys]−OH) that is cyclized via amide bonding of the side chain carboxy-function of Asp to the amino group of the side...

Innovative Grade US Origin Canine Beagle Plasma from Innovative Research was used in the following study:   An ultra-sensitive UHPLC-MS/MS assay for the quantification of orally administered vancomycin in plasma Max Sauter, Philipp Uhl, Kathrin I. Foerster, Isabelle Mohr, Rahel T. Hönec, Uta Merlec, Jürgen Burhenne, Walter E. Haefeli Journal of Pharmaceutical and Biomedical Analysis 27 June 2019 “…Vancomycin is a glyco-peptide antibiotic used intravenously for the treatment of gram-positive bacteria including multi-resistant Staphylococcus aureus and, as oral capsules, for the first-line treatment of gastro-intestinal Clostridium difficile infections (CDI). …Blank beagle plasma was purchased from Innovative Research (Novi, MI, USA)…”...

Innovative Research's Innovative Grade US Origin Beagle Plasma was recently used in the following study: Species-Dependent Chelation of 241Am by DTPA Di-Ethyl EsterJE Huckle, MP Sadgrove, RJ Mumper, M Jay - Health Physics, 2015...separation. The 241 Am(NO 3 ) 3 stock solution was obtained from Eckert & Ziegler Isotope Products (Valencia, CA, USA). Rat, beagle and human plasma were obtained from Innovative Research Inc. (Novi, MI, USA). Pierce...