Product References — Single Donor Human Cerebrospinal Fluid (CSF)

Abnormal LAMP1 glycosylation may play a role in Niemann-Pick disease, type C pathology

Posted by Corey Marcath on

Abnormal LAMP1 glycosylation may play a role in Niemann-Pick disease, type C pathology

Single Donor Human Cerebrospinal Fluid (CSF) from Innovative Research was used in the following study:   Abnormal LAMP1 glycosylation may play a role in Niemann-Pick disease, type C pathology Niamh X. Cawley ,Caitlin Sojka ,Antony Cougnoux,Anna T. Lyons,Elena‐Raluca Nicoli,Christopher A. Wassif,Forbes D. Porter PLOS ONE January 30, 2020 “…A hallmark of Niemann-Pick disease, type C (NPC) is the progressive degeneration of Purkinje neurons in the cerebellum caused by the accumulation of free cholesterol and glycosphingolipids in the lysosome. Recent studies suggest that the state of glycosylation of lysosomal membrane proteins may play a role in disease progression. Our study has...

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