Product References — Single Donor Human Plasma Whole Blood Derived

Bioanalysis of EGFRm inhibitor osimertinib, and its glutathione cycle- and desmethyl metabolites by liquid chromatography-tandem mass spectrometry

Posted by Corey Marcath on

Bioanalysis of EGFRm inhibitor osimertinib, and its glutathione cycle- and desmethyl metabolites by liquid chromatography-tandem mass spectrometry

Single Donor Human Plasma (Blood Derived) from Innovative Research was used in the following study:   Bioanalysis of EGFRm inhibitor osimertinib, and its glutathione cycle- and desmethyl metabolites by liquid chromatography-tandem mass spectrometry J.J.M Rood, M.J.van Haren, J.H.Beijnen, R.W.Sparidans Journal of Pharmaceutical and Biomedical Analysis January 2020 “…Osimertinib is a “third-generation’’ oral, irreversible, tyrosine kinase inhibitor. It is used in the treatment of non-small cellular lung carcinoma and spares wild-type EGFR. Due to its reactive nature, osimertinib is, in addition to oxidative routes, metabolized through GSH coupling and subsequent further metabolism of these conjugates. The extent of the non-oxidative metabolism...

Read more →

Direct Mass Spectrometry Analysis of Complex Mixtures by Nanoelectrospray with Simultaneous Atmospheric Pressure Chemical Ionization and Electrophoretic Separation Capabilities

Posted by Corey Marcath on

Direct Mass Spectrometry Analysis of Complex Mixtures by Nanoelectrospray with Simultaneous Atmospheric Pressure Chemical Ionization and Electrophoretic Separation Capabilities

Single Donor Human Serum Off The Clot, Single Donor Human Plasma (Blood Derived) from Innovative Research was used in the following study:   Direct Mass Spectrometry Analysis of Complex Mixtures by Nanoelectrospray with Simultaneous Atmospheric Pressure Chemical Ionization and Electrophoretic Separation Capabilities Dmytro S. Kulyk, Devin J. Swiner, Taghi Sahraeian, and Abraham K. Badu-Tawiah Analytical Chemistry August 26, 2019 “Accurate and rapid analysis of complex microsamples are challenging tasks in translational research. Nanoelectrospray ionization (nESI) is the method of choice for analyzing small sample volumes by mass spectrometry (MS), but this technique works well only for polar analytes. Herein, we...

Read more →

Mathematical model of thrombin generation and bleeding phenotype in Amish carriers of Factor IX:C deficiency vs. controls

Posted by Corey Marcath on

Mathematical model of thrombin generation and bleeding phenotype in Amish carriers of Factor IX:C deficiency vs. controls

Single Donor Human Plasma (Blood Derived) from Innovative Research was used in the following study:   Mathematical model of thrombin generation and bleeding phenotype in Amish carriers of Factor IX:C deficiency vs. controls S. Guptaa, M.C. Bravob, M. Heimana, C. Nakara, K. Brummel-Ziedinsb , C.H. Millerc, A. Shapiro Thrombosis Research 08 August 2019 “…Hemophilia B (HB) is an X-linked bleeding disorder resulting in a deficiency of FIX:C. Variable FIX:C levels can be seen in carriers within the same pedigree with a unifying mutation …therefore to ensure that other inheritable factors which could potentially impact coagulation did not affect the TG...

Read more →

Label-Free Optical Detection of Multiple Biomarkers in Sweat, Plasma, Urine, Saliva

Posted by Corey Marcath on

Label-Free Optical Detection of Multiple Biomarkers in Sweat, Plasma, Urine, Saliva

Single Donor Human Plasma (Blood Derived), Single Donor Human Serum Off The Clot from Innovative Research was used in the following study:   Label-Free Optical Detection of Multiple Biomarkers in Sweat, Plasma, Urine, Saliva Prajokta Ray, Andrew J.Steckl ACS Sensors 22 Mar 2019 ”We report a novel label-free quantitative detection of human performance “stress” biomarkers in different body fluids based on optical absorbance of the biomarkers in the ultraviolet (UV) region. …Human plasma and serum (single donor) were obtained from Innovative Research (Novi, MI)…”   Related products available from Innovative Research also include: Single Donor Human Plasma (Blood Derived) Single...

Read more →

Adhesion and invasion of gingival epithelial cells by Porphyromonas gulae

Posted by Corey Marcath on

Adhesion and invasion of gingival epithelial cells by Porphyromonas gulae

Single Donor Human Serum Off The Clot, Single Donor Human Plasma from Innovative Research was used in the following study:   Adhesion and invasion of gingival epithelial cells by Porphyromonas gulae Hiroaki Inaba ,Ryota Nomura,Yukio Kato,Hiroki Takeuchi,Atsuo Amano,Fumitoshi Asai,Kazuhiko Nakano,Richard J. Lamont,Michiyo Matsumoto-Nakano PLOS ONE March 14, 2019 "Porphyromonas gulae, an animal periodontal pathogen, possess fimbriae classified into three genotypes (A-C) based on the diversity of fimA genes encoding FimA. Accumulating evidence suggests that P. gulae strains with type C fimbriae are more virulent as compared to those with other types …Single donor human serum and plasma samples were used...

Read more →