The Binding Mechanisms of Antibodies to DNA from Healthy Subjects and Patients with Systemic Lupus Erythematosus: The Role of Monogamous Bivalency and Fc Dependence

The Binding Mechanisms of Antibodies to DNA from Healthy Subjects and Patients with Systemic Lupus Erythematosus: The Role of Monogamous Bivalency and Fc Dependence

Posted by Adam Awdish on

Single Donor Human Plasma (Blood Derived) from Innovative Research was used in the following study:

 

The Binding Mechanisms of Antibodies to DNA from Healthy Subjects and Patients with Systemic Lupus Erythematosus: The Role of Monogamous Bivalency and Fc Dependence

Morgan E. Belina, Diane M. Spencer, and David S. Pisetsky

ImmunoHorizons
February 1, 2022

Antibodies that target DNA (anti-DNA) are a unique subset of antibodies which bind to the structural components of DNA molecules. They were originally observed within the context of systemic lupus erythematosus (SLE), and anti-DNA in SLE appeared to have the ability to bind DNA regardless of the origin species. When anti-DNA initially was adopted for use in diagnosing SLE it was thought that the production of IgG anti-DNA was exclusive to bodies in the autoimmune state, however, data gathered over the years has clearly shown the presence of IgG antibodies to select bacterial and viral DNA in the blood of healthy subjects (HS). These IgG antibodies differ from low-affinity IgM, or natural autoantibodies, which can bind to DNA.

It is understood that SLE anti-DNA binds via Fc-dependent monogamous bivalency, a mechanism in which both Fab sites interact with the determinants on the same DNA molecule, expressing the low affinity of both sites. Researchers in this study sought to determine whether anti-DNA from HS are able to bind to bacterial DNA via Fc-dependent monogamous bivalency like anti-DNA found in the blood of SLE patients.

 

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Single Donor Human Serum Off The Clot

Pooled Human Serum Off The Clot

Pooled Human Plasma (Blood Derived)

  • Tags: Human Biological Fluids, Human Plasma, Pooled Human Plasma (Blood Derived), Single Donor Human Plasma Whole Blood Derived

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