Product References — Single Donor Human Red Blood Cells

Cathelicidin Peptides Restrict Bacterial Growth via Membrane Perturbation and Induction of Reactive Oxygen Species

Posted by Corey Marcath on

Cathelicidin Peptides Restrict Bacterial Growth via Membrane Perturbation and Induction of Reactive Oxygen Species

Single Donor Human Red Blood Cells from Innovative Research was used in the following study:   Cathelicidin Peptides Restrict Bacterial Growth via Membrane Perturbation and Induction of Reactive Oxygen Species Dean A. Rowe-Magnus, Adenine Y. Kao, Antonio Cembellin Prieto, Meng Pu, Cheng Kao American Society for Microbiology 10 September 2019 ”… All metazoans produce antimicrobial peptides (AMPs) that have both broad antimicrobial and immunomodulatory activity. Cathelicidins are AMPs that preferentially kill Gram-negative bacteria in vitro, purportedly by assembling into higher-order structures that perforate the membrane. We utilized high-resolution, single-cell fluorescence microscopy to examine their mechanism of action in real time....

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In vivo activity and low toxicity of the second-generation antimicrobial peptide DGL13K

Posted by Corey Marcath on

In vivo activity and low toxicity of the second-generation antimicrobial peptide DGL13K

Single Donor Human Red Blood Cells from Innovative Research was used in the following study:   In vivo activity and low toxicity of the second-generation antimicrobial peptide DGL13K Sven-Ulrik Gorr, Craig M. Flory, Robert J. Schumacher PLOS ONE May 9, 2019 “…Traditional antibiotics are losing their effectiveness due to increasing bacterial resistance. Combined with a decreasing pipeline of novel drugs, it is feared that many critical infections will be difficult or impossible to treat in the near future. …Human red blood cells (RBC) (single donor) were obtained from Innovative Research (Novi, MI)…”   Related products available from Innovative Research also...

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Small-molecule inhibitor of HlyU attenuates virulence of Vibrio species

Posted by Corey Marcath on

Small-molecule inhibitor of HlyU attenuates virulence of Vibrio species

Single Donor Human Red Blood Cells from Innovative Research was used in the following study:   Small-molecule inhibitor of HlyU attenuates virulence of Vibrio species Zee-Won Lee, Byoung Sik Kim, Kyung Ku Jang, Ye-Ji Bang, Suhyeon Kim, Nam-Chul Ha, Young Hyun Jung, Hyun Jik Lee, Ho Jae Han, Jong-Seo Kim, Jeesoo Kim, Pramod K. Sahu, Lak Shin Jeong, Myung Hee Kim, Sang Ho Choi Scientific Reports 13 March 2019 “…Increasing antibiotic resistance has led to the development of new strategies to combat bacterial infection…An aliquot of the supernatants was mixed with an equal volume of human erythrocytes (10% in PBS;...

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Antibacterial isoamphipathic oligomers highlight the importance of multimeric lipid aggregation for antibacterial potency

Posted by Leanne Kodsmann on

Antibacterial isoamphipathic oligomers highlight the importance of multimeric lipid aggregation for antibacterial potency

Human Red Blood Cells from Innovative Research were used in the following study:   Antibacterial isoamphipathic oligomers highlight the importance of multimeric lipid aggregation for antibacterial potency Joseph S. Brown, Zeinab J. Mohamed, Christine M. Artim, Dana N. Thornlow, Joseph F. Hassler, Vincent P. Rigoglioso, Susan Daniel & Christopher A. Alabi Communications Biology volume 1, Article number: 220 (2018) "... This work has focused on the development of new experimental parameters for membrane-targeting antimicrobials, outside of the known properties of cationic charge and hydrophobicity. OligoTEAs have enabled the synthesis of isoamphipathic oligomers to specifically probe additional parameters in membrane disruption....

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Synthesis of Lysine Mimicking Membrane Active Antimicrobial Polymers

Posted by Leanne Kodsmann on

Synthesis of Lysine Mimicking Membrane Active Antimicrobial Polymers

Single Donor Human Red Blood Cells from Innovative Research was used in the following study:   Synthesis of Lysine Mimicking Membrane Active Antimicrobial Polymers Ankita Arora, Wan Zheng, Hongjun Liang, Abhijit Mishra Advances in Polymer Sciences and Technology Materials Horizons: From Nature to Nanomaterials (2018). "... In this study, we synthesize lysine mimicking homopolymer and lysine mimicking copolymer with hydrophobic group and study their antimicrobial activity against both Gram-positive and Gram-negative bacteria. The advantage of using such antibiotic polymers over conventional AMPs is their scalability, cost-effectiveness and chemical stability in in vivo environment ... Fresh human red blood cell (HRBC)...

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