Product References — Single Donor Human Red Blood Cells

Environmentally Benign Nanoantibiotics with a Built-in Deactivation Switch Responsive to Natural Habitats

Posted by Corey Marcath on

Environmentally Benign Nanoantibiotics with a Built-in Deactivation Switch Responsive to Natural Habitats

Single Donor Human Red Blood Cells from Innovative Research was used in the following study:   Environmentally Benign Nanoantibiotics with a Built-in Deactivation Switch Responsive to Natural Habitats Wan ZhengWan Zheng, Miguel Anzaldua, Ankita Arora, Yunjiang Jiang, Kelly McIntyre, Michael Doerfert, Theodora Winter, Abhijit Mishra, Hairong Ma, and Hongjun Liang* American Chemical Society March 23, 2020 “In the battles against bacterial infections in healthcare and agriculture, antibiotics have been used at a massive scale for many decades. It was estimated that the annual antibiotics consumption reached 100 000−200 000 tons in 2010 worldwide, and up to 90% of the administered...

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Lipid Nanoparticles For Delivery of Bioactive Molecules

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Lipid Nanoparticles For Delivery of Bioactive Molecules

Single Donor Human Red Blood Cells from Innovative Research was used in the following study:   LIPID NANOPARTICLES FOR DELIVERY OF BIOACTIVE MOLECULES Mina Ordobadi University of British Columbia November 2019 “…Nanoparticle drug delivery vehicles can be used for in vivo delivery of a variety of bioactive molecules including nucleic acid polymers and small molecule drugs for applications ranging from gene therapy to improving the efficacy of anticancer drugs… Human erythrocytes (RBC) (Innovative Research, Novi, MI) were rinsed with 0.9% saline before use…”   Related products available from Innovative Research also include: Single Donor Human Red Blood Cells Single Donor...

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Cathelicidin Peptides Restrict Bacterial Growth via Membrane Perturbation and Induction of Reactive Oxygen Species

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Cathelicidin Peptides Restrict Bacterial Growth via Membrane Perturbation and Induction of Reactive Oxygen Species

Single Donor Human Red Blood Cells from Innovative Research was used in the following study:   Cathelicidin Peptides Restrict Bacterial Growth via Membrane Perturbation and Induction of Reactive Oxygen Species Dean A. Rowe-Magnus, Adenine Y. Kao, Antonio Cembellin Prieto, Meng Pu, Cheng Kao American Society for Microbiology 10 September 2019 ”… All metazoans produce antimicrobial peptides (AMPs) that have both broad antimicrobial and immunomodulatory activity. Cathelicidins are AMPs that preferentially kill Gram-negative bacteria in vitro, purportedly by assembling into higher-order structures that perforate the membrane. We utilized high-resolution, single-cell fluorescence microscopy to examine their mechanism of action in real time....

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In vivo activity and low toxicity of the second-generation antimicrobial peptide DGL13K

Posted by Corey Marcath on

In vivo activity and low toxicity of the second-generation antimicrobial peptide DGL13K

Single Donor Human Red Blood Cells from Innovative Research was used in the following study:   In vivo activity and low toxicity of the second-generation antimicrobial peptide DGL13K Sven-Ulrik Gorr, Craig M. Flory, Robert J. Schumacher PLOS ONE May 9, 2019 “…Traditional antibiotics are losing their effectiveness due to increasing bacterial resistance. Combined with a decreasing pipeline of novel drugs, it is feared that many critical infections will be difficult or impossible to treat in the near future. …Human red blood cells (RBC) (single donor) were obtained from Innovative Research (Novi, MI)…”   Related products available from Innovative Research also...

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Small-molecule inhibitor of HlyU attenuates virulence of Vibrio species

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Small-molecule inhibitor of HlyU attenuates virulence of Vibrio species

Single Donor Human Red Blood Cells from Innovative Research was used in the following study:   Small-molecule inhibitor of HlyU attenuates virulence of Vibrio species Zee-Won Lee, Byoung Sik Kim, Kyung Ku Jang, Ye-Ji Bang, Suhyeon Kim, Nam-Chul Ha, Young Hyun Jung, Hyun Jik Lee, Ho Jae Han, Jong-Seo Kim, Jeesoo Kim, Pramod K. Sahu, Lak Shin Jeong, Myung Hee Kim, Sang Ho Choi Scientific Reports 13 March 2019 “…Increasing antibiotic resistance has led to the development of new strategies to combat bacterial infection…An aliquot of the supernatants was mixed with an equal volume of human erythrocytes (10% in PBS;...

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