Product References — Animal Plasma

Soft-sheath, stiff-core microfiber hydrogel for coating vascular implants

Posted by Corey Marcath on

Soft-sheath, stiff-core microfiber hydrogel for coating vascular implants

Innovative Grade US Origin Bovine Plasma from Innovative Research was used in the following study:   Soft-sheath, stiff-core microfiber hydrogel for coating vascular implants P. Boodagha, R. Johnsona, C. Malya, Y. Dinga, W. Tana Colloids and Surfaces B: Biointerfaces 27 July 2019 “…Vascular implants remain clinically challenged due to often-occurring thrombosis and stenosis. Critical to addressing these complications is the design of implant material surfaces to inhibit the activities of platelets, smooth muscle cells (SMCs) and inflammatory cells. …The adhesion of platelets onto samples was studied by adding 300 μl of bovine platelet-rich plasma (Innovative Research, Novi, MI) to samples...

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A novel high-performance liquid chromatographic method combined with fluorescence detection for determination of ertugliflozin in rat plasma: Assessment of pharmacokinetic drug interaction potential of ertugliflozin with mefenamic acid and ketoconazole

Posted by Corey Marcath on

A novel high-performance liquid chromatographic method combined with fluorescence detection for determination of ertugliflozin in rat plasma: Assessment of pharmacokinetic drug interaction potential of ertugliflozin with mefenamic acid and ketoconazole

Innovative Grade US Origin Rat Sprague Dawley Plasma from Innovative Research was used in the following study:   A novel high-performance liquid chromatographic method combined with fluorescence detection for determination of ertugliflozin in rat plasma: Assessment of pharmacokinetic drug interaction potential of ertugliflozin with mefenamic acid and ketoconazole Dong-Gyun Han, Hwayoung Yun, In-Soo Yoon Journal of Chromatography B 25 May 2019 “…Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by insulin resistance and the inability of the body to secrete sufficient insulin, resulting in high blood glucose levels [1]. A recent survey estimated that T2DM affected 415 million...

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An ultra-sensitive UHPLC-MS/MS assay for the quantification of orally administered vancomycin in plasma

Posted by Corey Marcath on

An ultra-sensitive UHPLC-MS/MS assay for the quantification of orally administered vancomycin in plasma

Innovative Grade US Origin Canine Beagle Plasma from Innovative Research was used in the following study:   An ultra-sensitive UHPLC-MS/MS assay for the quantification of orally administered vancomycin in plasma Max Sauter, Philipp Uhl, Kathrin I. Foerster, Isabelle Mohr, Rahel T. Hönec, Uta Merlec, Jürgen Burhenne, Walter E. Haefeli Journal of Pharmaceutical and Biomedical Analysis 27 June 2019 “…Vancomycin is a glyco-peptide antibiotic used intravenously for the treatment of gram-positive bacteria including multi-resistant Staphylococcus aureus and, as oral capsules, for the first-line treatment of gastro-intestinal Clostridium difficile infections (CDI). …Blank beagle plasma was purchased from Innovative Research (Novi, MI, USA)…”...

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Oligo(Lactic Acid)8-Rapamycin Prodrug-Loaded Poly(Ethylene Glycol)-block-Poly(Lactic Acid) Micelles for Injection

Posted by Corey Marcath on

Oligo(Lactic Acid)8-Rapamycin Prodrug-Loaded Poly(Ethylene Glycol)-block-Poly(Lactic Acid) Micelles for Injection

Rat Sprague Dawley Plasma from Innovative Research was used in the following study:   Oligo(Lactic Acid)8-Rapamycin Prodrug-Loaded Poly(Ethylene Glycol)-block-Poly(Lactic Acid) Micelles for Injection Yu Tong Tam, Lauren Repp, Zhi-Xiong Ma, John B. Feltenberger, Glen S. Kwon Springer US 19 March 2019 ”…The mammalian target of rapamycin (mTOR) is part of an elaborate intracellular signaling network that is commonly dysregulated in human tumors, making it an attractive substrate for targeted anticancer therapies. Downstream from the PI3K/ AKT signaling pathway, mTOR plays a key role in cell growth, cell proliferation and angiogenesis. …Heparinized Sprague-Dawley rat plasma was purchased from Innovative Research Inc....

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Design, synthesis and evaluation of 111In labeled DOTA-conjugated tetrapeptides having high affinity and selectivity for mu opioid receptors

Posted by Leanne Kodsmann on

Design, synthesis and evaluation of 111In labeled DOTA-conjugated tetrapeptides having high affinity and selectivity for mu opioid receptors

CD-1 Mouse Plasma from Innovative Research was used in the following study:   Design, synthesis and evaluation of 111In labeled DOTA-conjugated tetrapeptides having high affinity and selectivity for mu opioid receptors John R. Lever, Emily A.Fergason-Cantrell, Terry L. Carmack, Lisa D. Watkinson, Fabio Gallazzi Nuclear Medicine and Biology Volume 70, March 2019, Pages 53-66 "... Peripheral mu (μ) opioid receptors are implicated in pain, bowel dysfunction and the progression of certain cancers. In an effort to identify radioligands well suited for imaging these peripheral sites, we have prepared and evaluated four hydrophilic [111In]-labeled, DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) conjugated μ tetrapeptides. ......

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