Product References — Animal Plasma

A Very Long-Acting IL-15: Implications for the Immunotherapy of Cancer

Posted by Adam Awdish on

A Very Long-Acting IL-15: Implications for the Immunotherapy of Cancer

Innovative Grade US Origin Mouse C57BL6 Plasma from Innovative Research was used in the following study:   A Very Long-Acting IL-15: Implications for the Immunotherapy of Cancer John A. Hangasky, Wei Chen, Sigrid Dubois, Anusara Daenthanasanmak, Jürgen Müller, Ralph Reid, Thomas A. Waldmann, and Daniel V. Santi Journal for Immunotherapy of Cancer January 31, 2022 Interleukin-15 (IL-15) is a protein essential for maintenance and survival of natural killer (NK) and CD8+ T cells, making it an interleukin of interest as an immune-oncology agent. IL-2 and IL-15 both bind to NK and CD8+ T cells, however, regulatory T cells are primarily...

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Sugar Shock: Probing Streptococcus Pyogenes Metabolism Through Bioluminescence Imaging

Posted by Adam Awdish on

Sugar Shock: Probing Streptococcus Pyogenes Metabolism Through Bioluminescence Imaging

Innovative Grade US Origin Mouse C57BL6 Plasma from Innovative Research was used in the following study:   Sugar Shock: Probing Streptococcus Pyogenes Metabolism Through Bioluminescence Imaging Richard W. Davis IV, Charlotte G. Muse, Heather Eggleston, Micaila Hill, Peter Panizzi bioRxiv January 16, 2022 Despite having limited use in diagnostic medical settings, light-producing bacterium can be extremely useful in pre-clinical experiments by giving the opportunity to track in real-time the spread of these pathogens throughout the course of an infection. A major limitation to using these pathogens in research, however, is the gap in understanding the changes in light production observed...

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Oligo(Lactic Acid)8-Docetaxel Prodrug-Loaded PEG-b-PLA Micelles for Prostate Cancer

Posted by Adam Awdish on

Oligo(Lactic Acid)8-Docetaxel Prodrug-Loaded PEG-b-PLA Micelles for Prostate Cancer

Innovative Grade US Origin Rat Sprague Dawley Plasma and Pooled Human Plasma (Blood Derived) from Innovative Research were used in the following study:   Oligo(Lactic Acid)8-Docetaxel Prodrug-Loaded PEG-b-PLA Micelles for Prostate Cancer Lauren Repp, Christopher J. Unterberger, Zhengqing Ye, John B. Feltenberger, Steven M. Swanson, Paul C. Marker and Glen S. Kwon Nanomaterials October 17, 2021 Despite the progress medical science has made over the years in the field of cancer treatment, chemotherapy remains to be one of the most common methods used to combat cancer. An issue that various anticancer drug classes still face, however, is that many of...

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An Effective and Safe Enkephalin Analog for Antinociception

Posted by Adam Awdish on

An Effective and Safe Enkephalin Analog for Antinociception

Innovative Grade US Origin Mouse C57BL6 Plasma from Innovative Research was used in the following study:   An Effective and Safe Enkephalin Analog for Antinociception K. K. DurgaRao Viswanadham, Roland Böttger, Lukas Hohenwarter, Anne Nguyen, Elham Rouhollahi, Alexander Smith, Yi-Hsuan Tsai, Yuan-Yu Chang, Christopher Llynard Ortiz, Lee-Wei Yang, Liliana Jimenez, Siyuan Li, Chan Hur, and Shyh-Dar Li Pharmaceutics June 22, 2021 Many injuries and diseases may lead to patients experiencing acute pain as a symptom, and a majority of surgery and trauma patients experience severe or intolerable pain that has the potential to result in chronic pain. Chronic pain is...

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Can Remdesivir and its Parent Nucleoside GS-441524 be Potential Oral Drugs? An in vitro and in vivo DMPK Assessment

Posted by Adam Awdish on

Can Remdesivir and its Parent Nucleoside GS-441524 be Potential Oral Drugs? An in vitro and in vivo DMPK Assessment

Innovative Grade US Origin Mouse CD1 Plasma and Pooled Human Plasma Apheresis Derived from Innovative Research were used in the following study:   Can Remdesivir and its Parent Nucleoside GS-441524 be Potential Oral Drugs? An in vitro and in vivo DMPK Assessment Jiashu Xie, Zhengqiang Wang Acta Pharmaceutica Sinica B March 5, 2021 To date, the only FDA-approved drug for treating COVID-19 is Remdesivir (RDV), which can only be administered intravenously. RDV is a ProTide drug derived from nucleoside GS-441524, and the potency of RDV is dependent on intracellular conversion into GS-441524 triphosphate. In vitro studies of RDV in human...

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