Product References — Animal Plasma

Development and validation of a UHPLC-MS/MS method to determine the bioavailability of warfarin and its major metabolite 7-hydroxy warfarin in rats dosed with oral formulations containing different polymorphic forms

Posted by Corey Marcath on

Development and validation of a UHPLC-MS/MS method to determine the bioavailability of warfarin and its major metabolite 7-hydroxy warfarin in rats dosed with oral formulations containing different polymorphic forms

Innovative Grade US Origin Rat Sprague Dawley Plasma from Innovative Research was used in the following study:   Development and validation of a UHPLC-MS/MS method to determine the bioavailability of warfarin and its major metabolite 7-hydroxy warfarin in rats dosed with oral formulations containing different polymorphic forms Diaa Shakleya, Ziyaur Rahman, Patrick J. Faustino Biomedical Chromatography 20 August 2019 “…A simple, sensitive and rapid UHPLC-ESI-MS/MS method was developed and validated for the quantification of warfarin and 7-hydroxy warfarin in SD rats… Blank rat plasma was purchased from Innovative Research Inc…”   Related products available from Innovative Research also include: Innovative...

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Soft-sheath, stiff-core microfiber hydrogel for coating vascular implants

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Soft-sheath, stiff-core microfiber hydrogel for coating vascular implants

Innovative Grade US Origin Bovine Plasma from Innovative Research was used in the following study:   Soft-sheath, stiff-core microfiber hydrogel for coating vascular implants P. Boodagha, R. Johnsona, C. Malya, Y. Dinga, W. Tana Colloids and Surfaces B: Biointerfaces 27 July 2019 “…Vascular implants remain clinically challenged due to often-occurring thrombosis and stenosis. Critical to addressing these complications is the design of implant material surfaces to inhibit the activities of platelets, smooth muscle cells (SMCs) and inflammatory cells. …The adhesion of platelets onto samples was studied by adding 300 μl of bovine platelet-rich plasma (Innovative Research, Novi, MI) to samples...

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A novel high-performance liquid chromatographic method combined with fluorescence detection for determination of ertugliflozin in rat plasma: Assessment of pharmacokinetic drug interaction potential of ertugliflozin with mefenamic acid and ketoconazole

Posted by Corey Marcath on

A novel high-performance liquid chromatographic method combined with fluorescence detection for determination of ertugliflozin in rat plasma: Assessment of pharmacokinetic drug interaction potential of ertugliflozin with mefenamic acid and ketoconazole

Innovative Grade US Origin Rat Sprague Dawley Plasma from Innovative Research was used in the following study:   A novel high-performance liquid chromatographic method combined with fluorescence detection for determination of ertugliflozin in rat plasma: Assessment of pharmacokinetic drug interaction potential of ertugliflozin with mefenamic acid and ketoconazole Dong-Gyun Han, Hwayoung Yun, In-Soo Yoon Journal of Chromatography B 25 May 2019 “…Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by insulin resistance and the inability of the body to secrete sufficient insulin, resulting in high blood glucose levels [1]. A recent survey estimated that T2DM affected 415 million...

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An ultra-sensitive UHPLC-MS/MS assay for the quantification of orally administered vancomycin in plasma

Posted by Corey Marcath on

An ultra-sensitive UHPLC-MS/MS assay for the quantification of orally administered vancomycin in plasma

Innovative Grade US Origin Canine Beagle Plasma from Innovative Research was used in the following study:   An ultra-sensitive UHPLC-MS/MS assay for the quantification of orally administered vancomycin in plasma Max Sauter, Philipp Uhl, Kathrin I. Foerster, Isabelle Mohr, Rahel T. Hönec, Uta Merlec, Jürgen Burhenne, Walter E. Haefeli Journal of Pharmaceutical and Biomedical Analysis 27 June 2019 “…Vancomycin is a glyco-peptide antibiotic used intravenously for the treatment of gram-positive bacteria including multi-resistant Staphylococcus aureus and, as oral capsules, for the first-line treatment of gastro-intestinal Clostridium difficile infections (CDI). …Blank beagle plasma was purchased from Innovative Research (Novi, MI, USA)…”...

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Oligo(Lactic Acid)8-Rapamycin Prodrug-Loaded Poly(Ethylene Glycol)-block-Poly(Lactic Acid) Micelles for Injection

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Oligo(Lactic Acid)8-Rapamycin Prodrug-Loaded Poly(Ethylene Glycol)-block-Poly(Lactic Acid) Micelles for Injection

Rat Sprague Dawley Plasma from Innovative Research was used in the following study:   Oligo(Lactic Acid)8-Rapamycin Prodrug-Loaded Poly(Ethylene Glycol)-block-Poly(Lactic Acid) Micelles for Injection Yu Tong Tam, Lauren Repp, Zhi-Xiong Ma, John B. Feltenberger, Glen S. Kwon Springer US 19 March 2019 ”…The mammalian target of rapamycin (mTOR) is part of an elaborate intracellular signaling network that is commonly dysregulated in human tumors, making it an attractive substrate for targeted anticancer therapies. Downstream from the PI3K/ AKT signaling pathway, mTOR plays a key role in cell growth, cell proliferation and angiogenesis. …Heparinized Sprague-Dawley rat plasma was purchased from Innovative Research Inc....

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