Product References — Animal Plasma

Can Remdesivir and its Parent Nucleoside GS-441524 be Potential Oral Drugs? An in vitro and in vivo DMPK Assessment

Posted by Adam Awdish on

Can Remdesivir and its Parent Nucleoside GS-441524 be Potential Oral Drugs? An in vitro and in vivo DMPK Assessment

Innovative Grade US Origin Mouse CD1 Plasma and Pooled Human Plasma Apheresis Derived from Innovative Research were used in the following study:   Can Remdesivir and its Parent Nucleoside GS-441524 be Potential Oral Drugs? An in vitro and in vivo DMPK Assessment Jiashu Xie, Zhengqiang Wang Acta Pharmaceutica Sinica B March 5, 2021 To date, the only FDA-approved drug for treating COVID-19 is Remdesivir (RDV), which can only be administered intravenously. RDV is a ProTide drug derived from nucleoside GS-441524, and the potency of RDV is dependent on intracellular conversion into GS-441524 triphosphate. In vitro studies of RDV in human...

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Interspecies Comparison of Simultaneous Thrombin and Plasmin Generation

Posted by Adam Awdish on

Interspecies Comparison of Simultaneous Thrombin and Plasmin Generation

Pooled Human Plasma (Blood Derived) and Innovative Grade US Origin Rabbit Plasma from Innovative Research was used in the following study:   Interspecies Comparison of Simultaneous Thrombin and Plasmin Generation Ivan D. Tarandovskiy, Hye Kyung H. Shin, Jin Hyen Baek, Elena Karnaukhova & Paul W. Buehler Scientific Reports March 3, 2020 Many fields of basic and pharmaceutical research use animal models of hemostasis and thrombosis and extrapolate the results in humans. However, data from animal models often is not accurate in predicting human responses to various biological factors, and assays provide limited relevant comparisons between human blood and blood of...

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Combined Thrombogenic Effects of Vessel Injury, Pregnancy and Procoagulant Immune Globulin Administration in Mice

Posted by Adam Awdish on

Combined Thrombogenic Effects of Vessel Injury, Pregnancy and Procoagulant Immune Globulin Administration in Mice

Innovative Grade US Origin Mouse C57BL6 Plasma and Pooled Human Plasma (Blood Derived) from Innovative Research was used in the following study:   Combined Thrombogenic Effects of Vessel Injury, Pregnancy and Procoagulant Immune Globulin Administration in Mice Yanqun Xu, Yideng Liang, Leonid Parunov, Daryl Despres, Michael Eckhaus, Dorothy Scott, Mikhail Ovanesov & Evi B. Struble Thrombosis Journal November 7, 2020 Normal pregnancies create hypercoagulable conditions within the body to naturally lower the risk of bleeding during birth. However, the changes observed in the hemostatic system also put pregnant women at risk of various thrombotic events (TEs), such as deep venous...

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Application of Triple Quadrupole Tandem Mass Spectrometry to the Bioanalysis of Collision-Induced Dissociation-Resistant Cyclic Peptides – Ultra-Sensitive Quantification of the Somatostatin-Analog Pasireotide Utilizing UHPLC-MS/MS

Posted by Adam Awdish on

Application of Triple Quadrupole Tandem Mass Spectrometry to the Bioanalysis of Collision-Induced Dissociation-Resistant Cyclic Peptides – Ultra-Sensitive Quantification of the Somatostatin-Analog Pasireotide Utilizing UHPLC-MS/MS

Innovative Grade US Origin Canine Beagle Single Donor Plasma from Innovative Research was used in the following study:   Application of Triple Quadrupole Tandem Mass Spectrometry to the Bioanalysis of Collision-Induced Dissociation-Resistant Cyclic Peptides – Ultra-Sensitive Quantification of the Somatostatin-Analog Pasireotide Utilizing UHPLC-MS/MS Max Sauter, Philipp Uhl, Jürgen Burhenne, Walter E. Haefeli Journal of Pharmaceutical and Biomedical Analysis February 5, 2021 Peptides are short chains of amino acids that are highly specific and are typically not rejected by host bodies, making them promising candidates in therapeutic drug development. Typical peptides are unfortunately vulnerable to enzymatic hydrolysis, and therefore sequences of...

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In Vitro and In Vivo Comparison of Curcumin-Encapsulated Chitosan-Coated Poly(lactic-co-glycolic acid) Nanoparticles and Curcumin/Hydroxypropyl-β-Cyclodextrin Inclusion Complexes Administered Intranasally as Therapeutic Strategies for Alzheimer’s Disease

Posted by Adam Awdish on

In Vitro and In Vivo Comparison of Curcumin-Encapsulated Chitosan-Coated Poly(lactic-co-glycolic acid) Nanoparticles and Curcumin/Hydroxypropyl-β-Cyclodextrin Inclusion Complexes Administered Intranasally as Therapeutic Strategies for Alzheimer’s Disease

Innovative Grade US Origin Mouse C57BL6 Plasma from Innovative Research was used in the following study:   In Vitro and In Vivo Comparison of Curcumin-Encapsulated Chitosan-Coated Poly(lactic-co-glycolic acid) Nanoparticles and Curcumin/Hydroxypropyl-β-Cyclodextrin Inclusion Complexes Administered Intranasally as Therapeutic Strategies for Alzheimer’s Disease Li Zhang, Shili Yang, Ling Rong Wong, Hui Xie, and Paul Chi-Lui Ho Molecular Pharmaceutics October 21, 2020 In 2018, the World Alzheimer Report stated that there were about 50 million Alzheimer’s disease (AD) patients worldwide, and they further estimated that the number of AD patients would reach 100 million by 2050. Some of the primary characteristics of AD...

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