Product References — Animal Plasma

Oligo(Lactic Acid)8-Rapamycin Prodrug-Loaded Poly(Ethylene Glycol)-block-Poly(Lactic Acid) Micelles for Injection

Posted by Corey Marcath on

Oligo(Lactic Acid)8-Rapamycin Prodrug-Loaded Poly(Ethylene Glycol)-block-Poly(Lactic Acid) Micelles for Injection

Rat Sprague Dawley Plasma from Innovative Research was used in the following study:   Oligo(Lactic Acid)8-Rapamycin Prodrug-Loaded Poly(Ethylene Glycol)-block-Poly(Lactic Acid) Micelles for Injection Yu Tong Tam, Lauren Repp, Zhi-Xiong Ma, John B. Feltenberger, Glen S. Kwon Springer US 19 March 2019 ”…The mammalian target of rapamycin (mTOR) is part of an elaborate intracellular signaling network that is commonly dysregulated in human tumors, making it an attractive substrate for targeted anticancer therapies. Downstream from the PI3K/ AKT signaling pathway, mTOR plays a key role in cell growth, cell proliferation and angiogenesis. …Heparinized Sprague-Dawley rat plasma was purchased from Innovative Research Inc....

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Design, synthesis and evaluation of 111In labeled DOTA-conjugated tetrapeptides having high affinity and selectivity for mu opioid receptors

Posted by Leanne Kodsmann on

Design, synthesis and evaluation of 111In labeled DOTA-conjugated tetrapeptides having high affinity and selectivity for mu opioid receptors

CD-1 Mouse Plasma from Innovative Research was used in the following study:   Design, synthesis and evaluation of 111In labeled DOTA-conjugated tetrapeptides having high affinity and selectivity for mu opioid receptors John R. Lever, Emily A.Fergason-Cantrell, Terry L. Carmack, Lisa D. Watkinson, Fabio Gallazzi Nuclear Medicine and Biology Volume 70, March 2019, Pages 53-66 "... Peripheral mu (μ) opioid receptors are implicated in pain, bowel dysfunction and the progression of certain cancers. In an effort to identify radioligands well suited for imaging these peripheral sites, we have prepared and evaluated four hydrophilic [111In]-labeled, DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) conjugated μ tetrapeptides. ......

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Orally Available Near Infrared Imaging Agents for the Early Detection of Diseases

Posted by Leanne Kodsmann on

Orally Available Near Infrared Imaging Agents for the Early Detection of Diseases

Mouse Plasma from Innovative Research was used in the following study:   Orally Available Near Infrared Imaging Agents for the Early Detection of Diseases Sumit Bhatnagar University of Michigan 2018 "... Mouse plasma (Innovative Research) was mixed with either 20 µM BODIPY FL, 50 µM of Hoechst dye, or 1 µM for Integrisense 680. After equilibration, the buffer in each chamber was adjusted to 50/50 mouse plasma and PBS to eliminate effects of protein binding on fluorescence. ..."   Related products available from Innovative Research also include: Innovative Grade US Origin Mouse Balb C Plasma Innovative Grade US Origin Mouse...

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Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound

Posted by Leanne Kodsmann on

Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound

Mouse CD1 Plasma, Rat Plasma, and Pooled Human Plasma from Innovative Research were used in the following study:   Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound Lara Pes, Stephan David Koester, Johannes Pall Magnusson, Serghei Chercheja, Federico Medda, Khalid Abu Ajaj, Didier Rognan, Steffen Daum, Friederike Inga Nollmann, Javier Garcia Fernandez, Patricia Perez Galan, Heidi-Kristin Walter, Anna Warnecke, Felix Kratz Journal of Controlled Release Volume 296, 28 February 2019, Pages 81-92 "... AE-KetoSulf07 and AE-Ester-Sulf07 are novel acid-sensitive albumin-binding prodrugs demonstrating tumor regressions in all of the evaluated human tumor xenograft...

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Bioanalytical method development and validation for determination of fibroblast growth factor peptide and its application to pharmacokinetic studies

Posted by Leanne Kodsmann on

Bioanalytical method development and validation for determination of fibroblast growth factor peptide and its application to pharmacokinetic studies

Innovative Grade US Origin Rat Wistar Plasma from Innovative Research was used in the following study:   Bioanalytical method development and validation for determination of fibroblast growth factor peptide and its application to pharmacokinetic studies Ing-orn Prasanchaimontri, Hardik Chandasana, Mohammad A. Akbar, Steven Swarts, Paul Okuneiff, Hartmut Derendorf European Journal of Pharmaceutics and Biopharmaceutics Volume 135, February 2019, Pages 83-93 "... Fibroblast growth factor peptide (FGF-P) is a polypeptide analog of FGF-2 that could be a potential mitigation and treatment agent for radiation syndromes. Prior to conducting preclinical pharmacokinetics, we developed and validated the LC-MS/MS bioanalytical method for determination of...

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