Product References — Rat Wistar Plasma

Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound

Posted by Leanne Kodsmann on

Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound

Mouse CD1 Plasma, Rat Plasma, and Pooled Human Plasma from Innovative Research were used in the following study:   Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound Lara Pes, Stephan David Koester, Johannes Pall Magnusson, Serghei Chercheja, Federico Medda, Khalid Abu Ajaj, Didier Rognan, Steffen Daum, Friederike Inga Nollmann, Javier Garcia Fernandez, Patricia Perez Galan, Heidi-Kristin Walter, Anna Warnecke, Felix Kratz Journal of Controlled Release Volume 296, 28 February 2019, Pages 81-92 "... AE-KetoSulf07 and AE-Ester-Sulf07 are novel acid-sensitive albumin-binding prodrugs demonstrating tumor regressions in all of the evaluated human tumor xenograft...

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Bioanalytical method development and validation for determination of fibroblast growth factor peptide and its application to pharmacokinetic studies

Posted by Leanne Kodsmann on

Bioanalytical method development and validation for determination of fibroblast growth factor peptide and its application to pharmacokinetic studies

Innovative Grade US Origin Rat Wistar Plasma from Innovative Research was used in the following study:   Bioanalytical method development and validation for determination of fibroblast growth factor peptide and its application to pharmacokinetic studies Ing-orn Prasanchaimontri, Hardik Chandasana, Mohammad A. Akbar, Steven Swarts, Paul Okuneiff, Hartmut Derendorf European Journal of Pharmaceutics and Biopharmaceutics Volume 135, February 2019, Pages 83-93 "... Fibroblast growth factor peptide (FGF-P) is a polypeptide analog of FGF-2 that could be a potential mitigation and treatment agent for radiation syndromes. Prior to conducting preclinical pharmacokinetics, we developed and validated the LC-MS/MS bioanalytical method for determination of...

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