Bioanalytical method development and validation for determination of fibroblast growth factor peptide and its application to pharmacokinetic studies

Bioanalytical method development and validation for determination of fibroblast growth factor peptide and its application to pharmacokinetic studies

Posted by Leanne Kodsmann on

Innovative Grade US Origin Rat Wistar Plasma from Innovative Research was used in the following study:

 

Bioanalytical method development and validation for determination of fibroblast growth factor peptide and its application to pharmacokinetic studies

Ing-orn Prasanchaimontri, Hardik Chandasana, Mohammad A. Akbar, Steven Swarts, Paul Okuneiff, Hartmut Derendorf

European Journal of Pharmaceutics and Biopharmaceutics
Volume 135, February 2019, Pages 83-93

"... Fibroblast growth factor peptide (FGF-P) is a polypeptide analog of FGF-2 that could be a potential mitigation and treatment agent for radiation syndromes. Prior to conducting preclinical pharmacokinetics, we developed and validated the LC-MS/MS bioanalytical method for determination of FGF-P in rat plasma for the first time. FGF-P was extracted from rat plasma using the protein precipitation technique followed liquid-liquid extraction using dichloromethane as a solvent ... Drug-free Wistar rat plasma with sodium ethylenediaminetetraacetic acid (EDTA) was purchased from Innovative Research, Inc. (Novi, MI, USA) and stored at -20 ° C..."

 

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  • Tags: Animal Plasma, Innovative Grade US Origin Rat Wistar Plasma, Rat Wistar Plasma

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