Product References — Pooled Human AB Serum Plasma Derived

HLA DRB1*15:01-DQB1*06:02-Restricted Human CD4+ T-Cells are Selectively Activated with Amoxicillin-Peptide Adducts

Posted by Adam Awdish on

HLA DRB1*15:01-DQB1*06:02-Restricted Human CD4+ T-Cells are Selectively Activated with Amoxicillin-Peptide Adducts

Pooled Human AB Serum Plasma Derived from Innovative Research was used in the following study:   HLA DRB1*15:01-DQB1*06:02-Restricted Human CD4+ T-Cells are Selectively Activated with Amoxicillin-Peptide Adducts Arun Tailor, Xiaoli Meng, Kareena Adair, John Farrell, James C Waddington, Ann Daly, Munir Pirmohamed, Gordon Dear, B Kevin Park, Dean J Naisbitt Toxicological Sciences August 10, 2020 Idiosyncratic drug-induced liver injury (DILI) is a major health concern often associated with a high patient death rate. Amoxicillin-clavulanate is the most common cause of DILI, and the detection of drug-specific CD4+ T-cells in patients with DILI suggests it originates somewhere in the immune system....

Read more →

Effects of Different Separation Methods on the Physical and Functional Properties of Extracellular Vesicles

Posted by Adam Awdish on

Effects of Different Separation Methods on the Physical and Functional Properties of Extracellular Vesicles

Pooled Human AB Serum Off The Clot from Innovative Research was used in the following study:   Effects of Different Separation Methods on the Physical and Functional Properties of Extracellular Vesicles Hyungtaek Jeon, Su-Kyung Kang, Myung-Shin Lee PLoS ONE July 7, 2020 Extracellular vesicles (EVs) are nano-sized membrane vesicles (20–500 nm) of endocytic origin that are secreted by most cells under normal physiological conditions, as well as by cells undergoing pathological processes. EVs contain a variety of molecules such as proteins, nucleic acids, and lipids, which are affected by environmental factors and health conditions, making them potential biomarkers for diseases...

Read more →

CD19-Targeted CAR Regulatory T Cells Suppress B Cell Pathology without GvHD

Posted by Adam Awdish on

CD19-Targeted CAR Regulatory T Cells Suppress B Cell Pathology without GvHD

Pooled Human AB Serum Plasma Derived from Innovative Research was used in the following study:   CD19-Targeted CAR Regulatory T Cells Suppress B Cell Pathology without GvHD Yuki Imura, Makoto Ando, Taisuke Kondo, Minako Ito, and Akihiko Yoshimura JCI Insight July 23, 2020 Tregs suppress excess immunity responses against a variety of antigens, including self-antigens, bacteria–derived antigens, and environmental allergens. Thus, Tregs have been shown to play important roles in suppressing the development of allergies. In humans, some clinical trials of transfer of ex vivo expanded polyclonal Tregs have been performed to suppress graft-versus-host disease (GvHD) after allogeneic hematopoietic stem...

Read more →

Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity

Posted by Corey Marcath on

Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity

Pooled Human AB Serum Plasma Derived from Innovative Research was used in the following study:   Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity Lee Faulkner, Andrew Gibson, Andrew Sullivan, Arun Tailor, Toru Usui, Ana Alfirevic, Munir Pirmohamed, Dean J. Naisbitt, B. Kevin Park Toxicological Sciences, Volume 154, Issue 2 December 2016 “…A number of serious adverse drug reactions are caused by T cells. An association with HLA alleles has been identified with certain reactions, which makes it difficult to develop standardized preclinical tests to predict chemical liability....

Read more →

CMV and EBV targets recognized by tumor-infiltrating B lymphocytes in pancreatic cancer and brain tumors

Posted by Leanne Kodsmann on

CMV and EBV targets recognized by tumor-infiltrating B lymphocytes in pancreatic cancer and brain tumors

Pooled Human AB Serum from Innovative Research was used in the following study:   CMV and EBV targets recognized by tumor-infiltrating B lymphocytes in pancreatic cancer and brain tumors Qingda Meng, Davide Valentini, Martin Rao, Ernest Dodoo & Markus Maeurer Scientific Reports November 2018. Scientific Reportsvolume 8, Article number: 17079 (2018) "... TILs from patients with pancreatic cancer or brain tumor were isolated and expanded in vitro with the addition of IL-2, IL-15 and IL-21 as previously described. Briefly, fresh tumor tissue was cut into 1-2 mm pieces using a sterile scalple, washed twice with cold PBS and cultured in...

Read more →