Product References — Pooled Human AB Serum Plasma Derived

Effects of Different Separation Methods on the Physical and Functional Properties of Extracellular Vesicles

Posted by Adam Awdish on

Effects of Different Separation Methods on the Physical and Functional Properties of Extracellular Vesicles

Pooled Human AB Serum Off The Clot from Innovative Research was used in the following study:   Effects of Different Separation Methods on the Physical and Functional Properties of Extracellular Vesicles Hyungtaek Jeon, Su-Kyung Kang, Myung-Shin Lee PLoS ONE July 7, 2020 Extracellular vesicles (EVs) are nano-sized membrane vesicles (20–500 nm) of endocytic origin that are secreted by most cells under normal physiological conditions, as well as by cells undergoing pathological processes. EVs contain a variety of molecules such as proteins, nucleic acids, and lipids, which are affected by environmental factors and health conditions, making them potential biomarkers for diseases...

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CD19-Targeted CAR Regulatory T Cells Suppress B Cell Pathology without GvHD

Posted by Adam Awdish on

CD19-Targeted CAR Regulatory T Cells Suppress B Cell Pathology without GvHD

Pooled Human AB Serum Plasma Derived from Innovative Research was used in the following study:   CD19-Targeted CAR Regulatory T Cells Suppress B Cell Pathology without GvHD Yuki Imura, Makoto Ando, Taisuke Kondo, Minako Ito, and Akihiko Yoshimura JCI Insight July 23, 2020 Tregs suppress excess immunity responses against a variety of antigens, including self-antigens, bacteria–derived antigens, and environmental allergens. Thus, Tregs have been shown to play important roles in suppressing the development of allergies. In humans, some clinical trials of transfer of ex vivo expanded polyclonal Tregs have been performed to suppress graft-versus-host disease (GvHD) after allogeneic hematopoietic stem...

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Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity

Posted by Corey Marcath on

Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity

Pooled Human AB Serum Plasma Derived from Innovative Research was used in the following study:   Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity Lee Faulkner, Andrew Gibson, Andrew Sullivan, Arun Tailor, Toru Usui, Ana Alfirevic, Munir Pirmohamed, Dean J. Naisbitt, B. Kevin Park Toxicological Sciences, Volume 154, Issue 2 December 2016 “…A number of serious adverse drug reactions are caused by T cells. An association with HLA alleles has been identified with certain reactions, which makes it difficult to develop standardized preclinical tests to predict chemical liability....

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CMV and EBV targets recognized by tumor-infiltrating B lymphocytes in pancreatic cancer and brain tumors

Posted by Leanne Kodsmann on

CMV and EBV targets recognized by tumor-infiltrating B lymphocytes in pancreatic cancer and brain tumors

Pooled Human AB Serum from Innovative Research was used in the following study:   CMV and EBV targets recognized by tumor-infiltrating B lymphocytes in pancreatic cancer and brain tumors Qingda Meng, Davide Valentini, Martin Rao, Ernest Dodoo & Markus Maeurer Scientific Reports November 2018. Scientific Reportsvolume 8, Article number: 17079 (2018) "... TILs from patients with pancreatic cancer or brain tumor were isolated and expanded in vitro with the addition of IL-2, IL-15 and IL-21 as previously described. Briefly, fresh tumor tissue was cut into 1-2 mm pieces using a sterile scalple, washed twice with cold PBS and cultured in...

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Development of a mass spectrometry based detection method for the mitochondrion‐derived peptide MOTS‐c in plasma samples for doping control purposes

Posted by Leanne Kodsmann on

Development of a mass spectrometry based detection method for the mitochondrion‐derived peptide MOTS‐c in plasma samples for doping control purposes

Human Plasma and Human AB Serum from Innovative Research were used in the following study:   Development of a mass spectrometry based detection method for the mitochondrion‐derived peptide MOTS‐c in plasma samples for doping control purposes Andre Knoop, Andreas Thomas, Mario Thevis Rapid Communications in Mass Spectrometry November 2018 "... In the field of anti-doping research, the development and improvement of detection methods concerning new substances that potentially exhibit performance-enhancing properties is of utmost importance ... For method development and validation, commercially available pooled human plasma (male AB plasma in K2EDTA) and human serum TYPE AB (male) from Innovative Research,...

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