Expression of Placenta-Specific 1 and its Potential for Eliciting Anti-Tumor Helper T-cell Responses in Head and Neck Squamous Cell Carcinoma

Expression of Placenta-Specific 1 and its Potential for Eliciting Anti-Tumor Helper T-cell Responses in Head and Neck Squamous Cell Carcinoma

Posted by Adam Awdish on

Pooled Human AB Serum Off The Clot from Innovative Research was used in the following study:

 

Expression of Placenta-Specific 1 and its Potential for Eliciting Anti-Tumor Helper T-cell Responses in Head and Neck Squamous Cell Carcinoma

Ryusuke Hayashi, Toshihiro Nagato, Takumi Kumai, Kenzo Ohara, Mizuho Ohara, Takayuki Ohkuri, Yui Hirata-Nozaki, Shohei Harabuchi, Akemi Kosaka, Marino Nagata, Yuki Yajima, Syunsuke Yasuda, Kensuke Oikawa, Michihisa Kono, Kan Kishibe, Miki Takahara, Akihiro Katada, Tatsuya Hayashi, Esteban Celis, Yasuaki Harabuchi, and Hiroya Kobayashi

OncoImmunology
December 29, 2020

Various cancers of the head and neck are frequent around the globe, with the most common type being head and neck squamous cell carcinoma (HNSCC). Although recent improvements in treatment have reduced the mortality rate associated with HNSCC, more than 65% of patients later develop recurrent metastatic diseases. Peptide vaccines were investigated as a possible treatment and preventative measure for these later diseases; however, they were shown to have weak efficacy in preclinical trials.

Placenta-specific 1 (PLAC1) is commonly expressed in placental trophoblasts, however it doesn’t appear in normal tissues, making it a potential biomarker and treatment target for cancer immunotherapy. This study looked into the presence of PLAC1 in tumors and the way it interacts with the body, specifically T-cells that target specific tumors and antigens. The findings suggest that PLAC1 could be a target antigen for helper T lymphocyte (HTL) immunotherapy.

 

Related products available from Innovative Research also include:

Pooled Human AB Serum Plasma Derived

Pooled Human Plasma Apheresis Derived

Single Donor Human Head and Neck Cancer Serum

  • Tags: Pooled Human AB Serum Off The Clot Heat Inactivated, Pooled Human AB Serum Plasma Derived, Pooled Human AB Serum Plasma Derived Heat Inactivated

    • The next big thing: it's what you do. The biological research materials you need to discover it? That's what we do! We love seeing how our products are being used in real-life applications and contributing to scientific acheivements every day. With thousands of published references and decades of proven results, you can count on us to help you source the high-quality biomaterials you need that will deliver reliable, consistent results - kit to kit, lot to lot, all study long. So what are you waiting for? All great discoveries start somewhere... yours starts with Innovative Research! Get in touch with our team today!



    ← Older Post Newer Post →

    ×