Product References — Innovative Grade US Origin Rat Wistar Plasma

Mechanistic insights into effect of surfactants on oral bioavailability of amorphous solid dispersions

Posted by Corey Marcath on

Mechanistic insights into effect of surfactants on oral bioavailability of amorphous solid dispersions

Innovative Grade US Origin Rat Wistar Plasma from Innovative Research was used in the following study:   Mechanistic insights into effect of surfactants on oral bioavailability of amorphous solid dispersions A.Schittny, S.Philipp-Bauer, P.Detampel, J.Huwyler, M.Puchkov Journal of Controlled Release 4/10/2020 “Reference and quality control samples consisted of Wistar rat plasma (innovative research, Novi, USA) spiked with an efavirenz in DMSO solution resulting in different concentrations of efavirenz at a constant content 0.1% DMSO in the plasma samples... Drug delivery of poorly soluble drugs in form amorphous solid dispersions (ASDs) is an appealing method to increase in vivo bioavailability. For rational...

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Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound

Posted by Leanne Kodsmann on

Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound

Mouse CD1 Plasma, Rat Plasma, and Pooled Human Plasma from Innovative Research were used in the following study:   Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound Lara Pes, Stephan David Koester, Johannes Pall Magnusson, Serghei Chercheja, Federico Medda, Khalid Abu Ajaj, Didier Rognan, Steffen Daum, Friederike Inga Nollmann, Javier Garcia Fernandez, Patricia Perez Galan, Heidi-Kristin Walter, Anna Warnecke, Felix Kratz Journal of Controlled Release Volume 296, 28 February 2019, Pages 81-92 "... AE-KetoSulf07 and AE-Ester-Sulf07 are novel acid-sensitive albumin-binding prodrugs demonstrating tumor regressions in all of the evaluated human tumor xenograft...

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Bioanalytical method development and validation for determination of fibroblast growth factor peptide and its application to pharmacokinetic studies

Posted by Leanne Kodsmann on

Bioanalytical method development and validation for determination of fibroblast growth factor peptide and its application to pharmacokinetic studies

Innovative Grade US Origin Rat Wistar Plasma from Innovative Research was used in the following study:   Bioanalytical method development and validation for determination of fibroblast growth factor peptide and its application to pharmacokinetic studies Ing-orn Prasanchaimontri, Hardik Chandasana, Mohammad A. Akbar, Steven Swarts, Paul Okuneiff, Hartmut Derendorf European Journal of Pharmaceutics and Biopharmaceutics Volume 135, February 2019, Pages 83-93 "... Fibroblast growth factor peptide (FGF-P) is a polypeptide analog of FGF-2 that could be a potential mitigation and treatment agent for radiation syndromes. Prior to conducting preclinical pharmacokinetics, we developed and validated the LC-MS/MS bioanalytical method for determination of...

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