Product References — Proteins

B- and T-lymphocyte attenuator stimulation protects against atherosclerosis by regulating follicular B cells

Posted by Corey Marcath on

B- and T-lymphocyte attenuator stimulation protects against atherosclerosis by regulating follicular B cells

Hamster Armenian IgG Affinity Purified from Innovative Research was used in the following study:   B- and T-lymphocyte attenuator stimulation protects against atherosclerosis by regulating follicular B cells Hidde Douna, Jacob Amersfoort, Frank H. Schaftenaar, Mara J. Kro¨ ner, Ma´te´ G. Kiss, Bram Slu¨ tter, Marie A. C. Depuydt, Mireia N. A. Bernabe´ Kleijn, Anouk Wezel, Harm J. Smeets, Hideo Yagita, Christoph J. Binder, I. Bot,Gijs H. M. van Puijvelde, Johan Kuiper, and Amanda C. Foks European Society of Cardiology 10 May 2019 “…Inflammation is a key process in the development of atherosclerosis. Components of both the innate and adaptive...

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Suppression of Choroidal Neovascularization and Fibrosis by a Novel RNAi Therapeutic Agent against (Pro)renin Receptor

Posted by Corey Marcath on

Suppression of Choroidal Neovascularization and Fibrosis by a Novel RNAi Therapeutic Agent against (Pro)renin Receptor

Human Prorenin Native Recombinant from Innovative Research was used in the following study:   Suppression of Choroidal Neovascularization and Fibrosis by a Novel RNAi Therapeutic Agent against (Pro)renin Receptor Ye Liu, Atsuhiro Kanda, Di Wu, Erdal Tan Ishizuka, Satoru Kase, Kousuke Noda, Atsuhiro Ichihara, Susumu Ishida Molecular Therapy Nucleic Acids May 28, 2019 “…Age-related macular degeneration (AMD) is the leading cause of irreversible blindness worldwide. The wet (neovascular or exudative) type of AMD usually causes severe vision loss and is characterized by choroidal neovascularization (CNV), which extends from the choroid into the subretinal space and disrupts Bruch’s membrane and the...

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Suppression of Choroidal Neovascularization and Fibrosis by a Novel RNAi Therapeutic Agent against (Pro)renin Receptor

Posted by Corey Marcath on

Suppression of Choroidal Neovascularization and Fibrosis by a Novel RNAi Therapeutic Agent against (Pro)renin Receptor

Human Prorenin Native Recombinant from Innovative Research was used in the following study:   Suppression of Choroidal Neovascularization and Fibrosis by a Novel RNAi Therapeutic Agent against (Pro)renin Receptor Ye Liu, Atsuhiro Kanda, Di Wu, Erdal Tan Ishizuka, Satoru Kase, Kousuke Noda, Atsuhiro Ichihara, and Susumu Ishida Molecular Therapy Nucleic Acids May 28, 2019 ”…Age-related macular degeneration (AMD) is the leading cause of irreversible blindness worldwide.1 The wet (neovascular or exudative) type of AMD usually causes severe vision loss and is characterized by choroidal neovascularization (CNV), which extends from the choroid into the subretinal space and disrupts Bruch’s membrane and...

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Structures of full-length plasma kallikrein bound to highly specific inhibitors describe a new mode of targeted inhibition

Posted by Corey Marcath on

Structures of full-length plasma kallikrein bound to highly specific inhibitors describe a new mode of targeted inhibition

tPA from Innovative Research was used in the following study:   Structures of full-length plasma kallikrein bound to highly specific inhibitors describe a new mode of targeted inhibition James R. Partridge, Rebea M. Choy, Abel Silva-Garcia, Chul Yu, Zhe Li, Hing Sham, Brian Metcalf Journal of Structural Biology 1 March 2019 "...Plasma kallikrein (pKal) is a serine protease responsible for cleaving high molecular-weight kininogen to produce the pro-inflammatory peptide, bradykinin. Unregulated pKal activity can lead to hereditary angioedema (HAE) following excess bradykinin release.tPA from Innovative Research (Novi MI)..."   Related products available from Innovative Research also include: Human Prekallikrein Purified tPA ...

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Cellular proliferation in mouse and human pancreatic islets is regulated by serpin B13 inhibition and downstream targeting of E-cadherin by cathepsin L

Posted by Leanne Kodsmann on

Cellular proliferation in mouse and human pancreatic islets is regulated by serpin B13 inhibition and downstream targeting of E-cadherin by cathepsin L

IgG isotype control from Innovative Research was used in the following study:   Cellular proliferation in mouse and human pancreatic islets is regulated by serpin B13 inhibition and downstream targeting of E-cadherin by cathepsin L Chi-Wen Lo, Yury Kryvalap, Tzong-jen Sheu, Ching-Ho Chang, Jan Czyzyk Diabetologia May 2019, Volume 62, Issue 5, pp 822–834 "... We used an in vitro culture system consisting of isolated pancreatic islets, an extract of pancreatic ductal epithelium and a monoclonal antibody (mAb) to serpin B13 or IgG isotype control. ... IgG isotype control (Innovative Research, Novi, MI, USA) were added to the islet cultures...

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