Posted by Adam Awdish on
Human Neutrophil Elastase Purified Lyophilized from Innovative Research was used in the following study:
Takumi Hiyoshi, Hisanori Domon, Tomoki Maekawa, Hikaru Tamura, Toshihito Isono, Satoru Hirayama, Karin Sasagawa, Fumio Takizawa, Koichi Tabeta, Yutaka Terao
May 17, 2022
Neutrophil elastase (NE) is a proteinase found abundantly in the azurophilic granules of neutrophils. NE is an indicator of neutrophil activity and acts as a host defense mechanism against pathogens by degrading microbiological components during phagocytosis. Excessive NE activity, however, is undesirable because NE can destroy human tissue thus harming the host, when found in high concentrations. NE inhibitors have proven to be effective in treating inflammatory lung diseases, which are characterized by extremely high NE levels. The NE inhibitors were shown to not only decrease inflammation but lowered NE levels as well in patients.
In another study, patients with gingivitis were found to have increased NE levels in the gingival crevicular fluid, and when the dental plaque was removed from the site of infection local inflammation decreased along with concentrations of NE. Further, patients with periodontitis - a bacteria-induced inflammatory disease that may lead to tooth loss - have been observed with NE activity that correlates to the degradation of the tooth’s attachment at the site of infection.
In this study, researchers examined NE activity in periodontal tissue to observe the effects of NE inhibitors on alveolar bone loss, bacterial load, and proinflammatory cytokine gene transcription. Furthermore, they evaluated the potential effects of NE had on the cleavage of cell adhesion molecules along with the effects it has on the disruption of the gingival epithelial barrier. Their findings demonstrated that NE cleaved various cell adhesion molecules and induced exfoliation of the epithelial keratinous layer in models of human oral tissue. They observed that periodontal pathogen was increased significantly following NE treatment; these findings all suggest that NE aggravates periodontitis if used to treat inflammation resulting from the bacterial infection.
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