Neutrophil Elastase Aggravates Periodontitis by Disrupting Gingival Epithelial Barrier via Cleaving Cell Adhesion Molecules

Neutrophil Elastase Aggravates Periodontitis by Disrupting Gingival Epithelial Barrier via Cleaving Cell Adhesion Molecules

Posted by Adam Awdish on

Human Neutrophil Elastase Purified Lyophilized from Innovative Research was used in the following study:

 

Neutrophil Elastase Aggravates Periodontitis by Disrupting Gingival Epithelial Barrier via Cleaving Cell Adhesion Molecules

Takumi Hiyoshi, Hisanori Domon, Tomoki Maekawa, Hikaru Tamura, Toshihito Isono, Satoru Hirayama, Karin Sasagawa, Fumio Takizawa, Koichi Tabeta, Yutaka Terao

Scientific Reports
May 17, 2022

Neutrophil elastase (NE) is a proteinase found abundantly in the azurophilic granules of neutrophils. NE is an indicator of neutrophil activity and acts as a host defense mechanism against pathogens by degrading microbiological components during phagocytosis. Excessive NE activity, however, is undesirable because NE can destroy human tissue thus harming the host, when found in high concentrations. NE inhibitors have proven to be effective in treating inflammatory lung diseases, which are characterized by extremely high NE levels. The NE inhibitors were shown to not only decrease inflammation but lowered NE levels as well in patients.

In another study, patients with gingivitis were found to have increased NE levels in the gingival crevicular fluid, and when the dental plaque was removed from the site of infection local inflammation decreased along with concentrations of NE. Further, patients with periodontitis - a bacteria-induced inflammatory disease that may lead to tooth loss - have been observed with NE activity that correlates to the degradation of the tooth’s attachment at the site of infection.

In this study, researchers examined NE activity in periodontal tissue to observe the effects of NE inhibitors on alveolar bone loss, bacterial load, and proinflammatory cytokine gene transcription. Furthermore, they evaluated the potential effects of NE had on the cleavage of cell adhesion molecules along with the effects it has on the disruption of the gingival epithelial barrier. Their findings demonstrated that NE cleaved various cell adhesion molecules and induced exfoliation of the epithelial keratinous layer in models of human oral tissue. They observed that periodontal pathogen was increased significantly following NE treatment; these findings all suggest that NE aggravates periodontitis if used to treat inflammation resulting from the bacterial infection.

 

Related products available from Innovative Research also include:

Human Neutrophil Elastase ELISA Kit

Rabbit Anti Human Elastase Polyclonal Ammonium Sulfate Purified

Human Elastase 2 Neutrophil CLIA Kit

  • Tags: Human Biological Fluids, Human Neutrophil Elastase Purified Lyophilized, neutrophil elastase, Proteins

    • The next big thing: it's what you do. The biological research materials you need to discover it? That's what we do! We love seeing how our products are being used in real-life applications and contributing to scientific acheivements every day. With thousands of published references and decades of proven results, you can count on us to help you source the high-quality biomaterials you need that will deliver reliable, consistent results - kit to kit, lot to lot, all study long. So what are you waiting for? All great discoveries start somewhere... yours starts with Innovative Research! Get in touch with our team today!


    Related Posts

    Detection of SARS-CoV-2 RNA through Tandem Isothermal Gene Amplification without Reverse Transcription
    Pooled Human Plasma (Blood Derived) from Innovative Research was used in the following ...
    Read the Article
    Development of a dual antigen lateral flow immunoassay for detecting Yersinia pestis
    Pooled Human Serum Off The Clot from Innovative Research was used in the following stud...
    Read the Article
    PD-LAMP Smartphone Detection of SARS-CoV-2 on Chip
    Pooled Human Saliva from Innovative Research was used in the following study:   PD-LAM...
    Read the Article

    ← Older Post Newer Post →

    ×