Product References — Human Plasma

Identification of Receptor Ligands in Apo B100 Reveals Potential Functional Domains

Posted by Leanne Kodsman on

Identification of Receptor Ligands in Apo B100 Reveals Potential Functional Domains

Normal Single Donor Human Plasma from Innovative Research was recently used in the following study: Identification of Receptor Ligands in Apo B100 Reveals Potential Functional Domains Juan Guevara Jr., Jamie Romo Jr., Ernesto Hernandez, Natalia Valentinova Guevara The Protein Journal, 26 September 2018 "... The actual receptor ligand(s) in apolipoprotein B100, one of the main proteins of LLP, remain(s) unknown. The objective of this study was to identify true receptor ligand(s) in apo B100, a molecule of 4563 residues... LDL Purification Highly purified preparations of low-density lipoproteins were obtained from single donor human plasma with sodium-EDTA added at time of...

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Development and validation of LC-MS/MS method for quantification of bictegravir in human plasma and its application to an intracellular uptake study

Posted by Leanne Kodsman on

Human Plasma with K2 EDTA from Innovative Research was recently used in the following study: Development and validation of LC-MS/MS method for quantification of bictegravir in human plasma and its application to an intracellular uptake study Pavan Kumar Prathipati, Subhra Mandal, Christopher J. Destache Biomedical Chromatography, September 2018 " ... A sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for quantification of bictegravir in human plasma... Dipotassium ethylenediaminetetraacetic acid (K2EDTA) plasma was purchased from Innovative Research (Novi, MI)... Six different sources of K2EDTA human blank plasma were extracted and the peak areas at the retention time of...

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Effect of CYP2C9 Polymorphisms on the Pharmacokinetics of Indomethacin During Pregnancy

Posted by Leanne Kodsman on

Pooled Normal Human Plasma from Innovative Research was recently used in the following study: Effect of CYP2C9 Polymorphisms on the Pharmacokinetics of Indomethacin During PregnancyMansi Shah, Meixiang Xu, Poonam Shah, Xiaoming Wang, Shannon M. Clark, Maged Costantine, Holly A. West, Tatiana N. Nanovskaya, Mahmoud S. Ahmed, Sherif Z. Abdel-Rahman, Raman Venkataramanan, Steve N. Caritis, Gary D. V. Hankins, Erik Rytting European Journal of Drug Metabolism and Pharmacokinetics, August 2018 "... Plasma concentrations of indomethacin and DMI at steady state were analyzed with a validated LC-MS/MS method. DNA was isolated from subject blood and buccal smear samples. Subjects were grouped by...

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Bioanalytical liquid chromatography-tandem mass spectrometric assay for the quantification of the ALK inhibitors alectinib, brigatinib and lorlatinib in plasma and mouse tissue homogenates

Posted by Leanne Kodsman on

Normal Single Donor Human Plasma from Innovative Research was recently used in the following study: Bioanalytical liquid chromatography-tandem mass spectrometric assay for the quantification of the ALK inhibitors alectinib, brigatinib and lorlatinib in plasma and mouse tissue homogenatesRolf W. Sparidans, Wenlong Li, Alfred H. Schinkel, Jan H.M. Schellens, Jos H. Beijnen Journal of Pharmaceutical and Biomedical Analysis, August 2018 " ... Several second and third generation ALK inhibitors have been introduced in recent years. A bioanalytical assay for simultaneous quantification of alectinib, brigatinib, and lorlatinib was developed and validated for human plasma. The method was also partially validated for diluted...

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Heterogeneous expression of cytokines accounts for clinical diversity and refines prognostication in CMML

Posted by Leanne Kodsman on

Normal Single Donor Human Plasma from Innovative Research was recently used in the following study: Heterogeneous expression of cytokines accounts for clinical diversity and refines prognostication in CMMLSandrine Niyongere, Nolwenn Lucas, Jun-Min Zhou, Samer Sansil, Anthony D. Pomicter, Maria E. Balasis, John Robinson, Jodi Kroeger, Qing Zhang, Yu Long Zhao, Markus Ball, Rami Komrokji, Alan List, Michael W. Deininger, Brooke L. Fridley, Valeria Santini, Eric Solary & Eric Padron Nature: Lukemia, July 2018 "... Fifteen single donor healthy control plasma samples were purchased from Innovative Research (Innovative Research, Inc., Novi, MI) with an average age 66 (range 60-80) and a...

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