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Scientists from the University of New York at Buffalo published a study in Science Advances that supports that overexpression of the transcription factor NANOG can reverse the signs of cellular aging in muscles without having to revert the cells to a stem-cell like state. The work could help lead to new treatments or therapies that help reverse cellular senescence, and aid the many people suffering from age-related disorders. Read the study in Science Advances.  Ameliorating the hallmarks of cellular senescence in skeletal muscle myogenic progenitors in vitro and in vivo Aref Shahini, Nika Rajabian, Debanik Choudhury, Shahryar Shahini, Kalyan Vydiam, Thy...

Diseases such as Pandemic Influenza and COVID-19, among others, support the utility of rapid point-of-need field analysis of samples for respiratory pathogens. Researchers at Wayne State University used rapid, reagent-less Raman based diagnostics for point-of-need pathogen detection. Results took less than 2 minutes to display. The application of Raman spectroscopy in this context has the added benefit of not requiring primers, probes, or perishable detection materials. Combined with multiclass machine learning spectral analysis via Gradient Boosting Machine, accurate identification of SARS-CoV-2, human coronaviruses OC43, NL63, 229E, Influenza A (H1N1), respiratory syncytial virus, and Streptococcus pyogenes in spiked clinical nasal swab...

As part of the explosion of knowledge and potential applications to human health that the “omics” revolution has provided us, the realization that sole focus upon any one area of study therein will not lead to a full capitalization upon the potential opportunities that omics present us with. In the field of metabolomics, as with other disciplines, the need to understand biological processes at ever increasing levels of detail, often from complex matrices, and to do so faster, with greater precision and specificity, has driven significant research effort into the design and development of suitable sample introduction methods into today’s...

A new study published in Blood Advances uses Innovative Research recombinant tissue-type plasminogen activator (tPA) Absence of hyperfibrinolysis may explain lack of efficacy of tranexamic acid in hypoproliferative thrombocytopenia Anton Ilich, Terry B Gernsheimer, Darrell J Triulzi, Heather Herren, Siobhan P Brown, Lori A. Holle, Andrew T. Lucas, Bas de Laat, Nahed El Kassar, Alisa S. Wolberg, Susanne May, Nigel S Key Blood AdvancesAugust 31, 2022 https://doi.org/10.1182/bloodadvances.2022008255 Key Points No evidence of fibrinolytic activation was observed in patients with hypoproliferative thrombocytopenia tPA-based fibrinolytic assays correlated well with TXA plasma concentrations and may be used as PD parameters in clinical trials of TXA The American Trial Using Tranexamic Acid (TXA) in Thrombocytopenia...

Human Factor II (Prothrombin) Purified, Human Fibrinogen Purified, and Rabbit Anti Mouse/Rat Fibrinogen Polyclonal Affinity Purified from Innovative Research were used in the following study:   Contribution of Coagulases towards Staphylococcus aureus Disease and Protective Immunity Alice G. Cheng, Molly McAdow, Hwan K. Kim, Taeok Bae, Dominique M. Missiakas, Olaf Schneewind PLOS Pathogens August 5, 2010 Staphylococcus aureus is a bacterium responsible for many common infections, including bacteremia, pneumonia, soft tissue infections, and septic arthritis among others. There remains no known way to gain protective immunity against S. aureus diseases, and researchers continue to investigate options for an effective vaccine....