Product References — Animal Plasma
Mechanistic insights into effect of surfactants on oral bioavailability of amorphous solid dispersions
Posted by Corey Marcath on
Innovative Grade US Origin Rat Wistar Plasma from Innovative Research was used in the following study: Mechanistic insights into effect of surfactants on oral bioavailability of amorphous solid dispersions A.Schittny, S.Philipp-Bauer, P.Detampel, J.Huwyler, M.Puchkov Journal of Controlled Release 4/10/2020 “Reference and quality control samples consisted of Wistar rat plasma (innovative research, Novi, USA) spiked with an efavirenz in DMSO solution resulting in different concentrations of efavirenz at a constant content 0.1% DMSO in the plasma samples... Drug delivery of poorly soluble drugs in form amorphous solid dispersions (ASDs) is an appealing method to increase in vivo bioavailability. For rational...
Development and validation of a UHPLC-MS/MS method to determine the bioavailability of warfarin and its major metabolite 7-hydroxy warfarin in rats dosed with oral formulations containing different polymorphic forms
Posted by Corey Marcath on
Innovative Grade US Origin Rat Sprague Dawley Plasma from Innovative Research was used in the following study: Development and validation of a UHPLC-MS/MS method to determine the bioavailability of warfarin and its major metabolite 7-hydroxy warfarin in rats dosed with oral formulations containing different polymorphic forms Diaa Shakleya, Ziyaur Rahman, Patrick J. Faustino Biomedical Chromatography 20 August 2019 “…A simple, sensitive and rapid UHPLC-ESI-MS/MS method was developed and validated for the quantification of warfarin and 7-hydroxy warfarin in SD rats… Blank rat plasma was purchased from Innovative Research Inc…” Related products available from Innovative Research also include: Innovative...
Soft-sheath, stiff-core microfiber hydrogel for coating vascular implants
Posted by Corey Marcath on
Innovative Grade US Origin Bovine Plasma from Innovative Research was used in the following study: Soft-sheath, stiff-core microfiber hydrogel for coating vascular implants P. Boodagha, R. Johnsona, C. Malya, Y. Dinga, W. Tana Colloids and Surfaces B: Biointerfaces 27 July 2019 “…Vascular implants remain clinically challenged due to often-occurring thrombosis and stenosis. Critical to addressing these complications is the design of implant material surfaces to inhibit the activities of platelets, smooth muscle cells (SMCs) and inflammatory cells. …The adhesion of platelets onto samples was studied by adding 300 μl of bovine platelet-rich plasma (Innovative Research, Novi, MI) to samples...
A novel high-performance liquid chromatographic method combined with fluorescence detection for determination of ertugliflozin in rat plasma: Assessment of pharmacokinetic drug interaction potential of ertugliflozin with mefenamic acid and ketoconazole
Posted by Corey Marcath on
Innovative Grade US Origin Rat Sprague Dawley Plasma from Innovative Research was used in the following study: A novel high-performance liquid chromatographic method combined with fluorescence detection for determination of ertugliflozin in rat plasma: Assessment of pharmacokinetic drug interaction potential of ertugliflozin with mefenamic acid and ketoconazole Dong-Gyun Han, Hwayoung Yun, In-Soo Yoon Journal of Chromatography B 25 May 2019 “…Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by insulin resistance and the inability of the body to secrete sufficient insulin, resulting in high blood glucose levels [1]. A recent survey estimated that T2DM affected 415 million...
An ultra-sensitive UHPLC-MS/MS assay for the quantification of orally administered vancomycin in plasma
Posted by Corey Marcath on
Innovative Grade US Origin Canine Beagle Plasma from Innovative Research was used in the following study: An ultra-sensitive UHPLC-MS/MS assay for the quantification of orally administered vancomycin in plasma Max Sauter, Philipp Uhl, Kathrin I. Foerster, Isabelle Mohr, Rahel T. Hönec, Uta Merlec, Jürgen Burhenne, Walter E. Haefeli Journal of Pharmaceutical and Biomedical Analysis 27 June 2019 “…Vancomycin is a glyco-peptide antibiotic used intravenously for the treatment of gram-positive bacteria including multi-resistant Staphylococcus aureus and, as oral capsules, for the first-line treatment of gastro-intestinal Clostridium difficile infections (CDI). …Blank beagle plasma was purchased from Innovative Research (Novi, MI, USA)…”...