Poly (Ethylene Glycol)-Block-Poly (D, L-lactide) (PEG-PLA) Micelles for Brain Delivery of Baicalein through Nasal Route for Potential Treatment of Neurodegenerative Diseases due to Oxidative Stress and Inflammation: An in vitro and in vivo Study

Poly (Ethylene Glycol)-Block-Poly (D, L-lactide) (PEG-PLA) Micelles for Brain Delivery of Baicalein through Nasal Route for Potential Treatment of Neurodegenerative Diseases due to Oxidative Stress and Inflammation: An in vitro and in vivo Study

Posted by Adam Awdish on

Innovative Grade US Origin Mouse C57BL6 Plasma from Innovative Research was used in the following study:

 

Poly (Ethylene Glycol)-Block-Poly (D, L-lactide) (PEG-PLA) Micelles for Brain Delivery of Baicalein through Nasal Route for Potential Treatment of Neurodegenerative Diseases due to Oxidative Stress and Inflammation: An in vitro and in vivo Study

Li Zhang, Shili Yang, Lizhen Huang, Paul Chi-Lui Ho

International Journal of Pharmaceutics
October 15, 2020

Baicalein (BE) is a flavonoid isolated from Scutellaria radix roots. Previous studies have already demonstrated that BE has various pharmacological effects on the brain, including antioxidant and anti-inflammatory effects, that contribute to its neuroprotective properties.

The brains of patients suffering from central nervous system (CNS) neurodegenerative diseases show extensive signs of oxidative stress and neuro-inflammation. It has thus been hypothesized that BE could be a potential treatment option for CNS neurodegenerative diseases due to its antioxidant and anti-inflammatory effects. However, the application of BE in CNS neurodegenerative disease treatment has been hampered due to its poor solubility and low oral bioavailability.

This study sought to create a new treatment mechanism for BE by encapsulating it into poly (ethylene glycol)-block-poly (D, L-lactide) micelles (BE-MC) and administering it via nasal inhalation to enhance its distribution in the brain. Results indicated that BE-MC showed comparable in-vitro antioxidant activity to BE solution without causing death of healthy cells, suggesting that nasal administration of BE-MC could be a useful treatment of CNS neurodegenerative diseases.

 

Related products available from Innovative Research also include:

Rat Sprague Dawley Plasma

Mouse CD1 Red Blood Cells

Pooled Human Plasma Apheresis Derived

  • Tags: Animal Plasma, Innovative Grade US Origin Mouse C57BL6 Plasma

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