Single Donor Human Pediatric SARS-Cov-2 Positive Plasma from Innovative Research is a whole blood derived product processed using EDTA as the anticoagulant. Samples were collected from pediatric donors through an IRB-approved protocol, and COVID-19 positive status has been confirmed via SARS-CoV-2 IgG antibody assay and/or PCR positive test results. Please note that this product will contain differing levels of IgM, IgA, and/or IgG antibody levels from lot to lot as this is a single donor product. This plasma is suitable for use as a positive control and to confirm antibody assay results, among other research applications. This product has not been tested directly for the presence of any other viruses, and out of an abundance of caution it is recommended to handle as if capable of spreading infectious disease.

Viral Testing: Each unit is tested for the standard FDA-required viral markers, and found negative for HBsAg, HCV, HIV-1, HIV-2, HIV-1Ag or HIV-1 NAT, ALT, and syphilis using FDA-approved methods. If you would like any further testing or analysis performed prior to shipping, please let us know.

• Preheat a water bath to 37 C.
• Place the frozen plasma sample directly in the water bath.
• Gently agitate the plasma sample every 5-10 minutes to insure even thawing.
• The total thawing time will depend on the frozen sample volume. A 10 ml sample might be thawed completely in 5 minutes, but a large sample could take up to 1 hour.
• The thawed sample should be used immediately or stored at 4 C for up to 24 hours. Liquid plasma should never be kept on ice or stored below 0 C as the cold may cause clotting.
• Plasma should be visually inspected for signs of clotting or precipitation before use in experiments. A coagulation test such as aPTT can also be performed to verify the preservation of the hemostasis system.
• Plasma should always be snap-frozen by placing the tube in dry ice for at least 1 hour. Large containers can be covered in dry ice for even freezing.
• Frozen plasma should be stored at –20 C or colder. Lower temperatures will help preserve labile plasma proteins for longer time periods.

This protocol is applicable for plasma containing any anticoagulant of both human and animal origin. While handling serum does not involve the same risk of clotting due to improper handling, we recommend following the above instructions for both plasma and serum for best results

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This material is sold for in-vitro use only for manufacturing and research. This material is not suitable for human or animal use. While we make every effort to ensure the safety of our products, we recommend handling any biological materials with standard precautions as if capable of spreading infectious disease. The statements herin are offered for informational purposes only to be used solely for your consideration, investigation, and verification.

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