Rabbit Anti SHH Polyclonal Affinity Purified (PBS with 0.05% sodium azide and 50% glycerol, pH7.4) (IHC,Sandwich ELISA) from Innovative Research is a polyclonal antibody in a liquid format, buffered in PBS with 0.05% sodium azide and 50% glycerol, pH7.4 This antibody has been affinity purified.

More Details:

• Host: Rabbit
• Species: Human,Mouse,Rat
• Target: SHH
• Clonality: Polyclonal
• Purity: Affinity Purified
• Immunogen: Synthetic peptide of human SHH
• Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles.

This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities.

This product can be used in analytical tools such as IHC,Sandwich ELISA.

At Innovative Research, we provide reliable, consistent products that deliver reliable, consistent results.

For research use only.

Click here to view a video tutorial covering frequently asked questions regarding ELISA workflows.

View all citations/references for Antibodies

View all citations and product references

This material is sold for in-vitro use only for manufacturing and research. This material is not suitable for human or animal use. While we make every effort to ensure the safety of our products, we recommend handling any biological materials with standard precautions as if capable of spreading infectious disease. The statements herin are offered for informational purposes only to be used solely for your consideration, investigation, and verification.

Please be aware the image pictured is for illustrative purposes only, and your product packaging and appearance may vary.

No Data Sheets available