Rabbit Anti JUN Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4) (IHC)

Rabbit Anti JUN Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4) (IHC) from Innovative Research is a polyclonal antibody in a liquid format, buffered in PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4 This antibody has been affinity purified.

More Details:

• Host: Rabbit
• Species: Human,Mouse,Rat
• Target: JUN
• Clonality: Polyclonal
• Purity: Affinity Purified
• Immunogen: KLH conjugated Synthetic peptide corresponding to Human c-Jun.
• Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles.

JUN is also named as c-Jun and AP1,belongs to the bZIP family and Jun subfamily. JUN,the most extensively studied protein of the activator protein-1 (AP-1) complex,is involved in numerous cell activities,such as proliferation,apoptosis,survival,tumorigenesis and tissue morphogenesis. JUN is a transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. It promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. JUN is a basic leucine zipper (bZIP) transcription factor that acts as homo- or heterodimer,binding to DNA and regulating gene transcription. In additon,extracellular signals can induce post-translational modifications of JUN,resulting in altered transcriptional activity and target gene expression. More over,it has uncovered multiple layers of a complex regulatory scheme in which JUN is able to crosstalk,amplify and integrate different signals for tissue development and disease. Jun is predominantly nuclear,ubiquitinated Jun colocalizes with lysosomal proteins.

This product can be used in analytical tools such as IHC.

At Innovative Research, we provide reliable, consistent products that deliver reliable, consistent results.

For research use only.

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This material is sold for in-vitro use only for research. This material is not suitable for human or animal use. While we make every effort to ensure the safety of our products, we recommend handling any biological materials with standard precautions as if capable of spreading infectious disease. The statements herein are offered for informational purposes only to be used solely for your consideration, investigation, and verification.

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