Rabbit Anti Human ERBB2 Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4) (Western Blot) from Innovative Research is a polyclonal antibody in a liquid format, buffered in PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4 This antibody has been affinity purified.

More Details:

• Host: Rabbit
• Species: Human
• Target: ERBB2
• Clonality: Polyclonal
• Purity: Affinity Purified
• Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse ErbB2
• Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles.

HER2,also known as ErbB2 and Neu,is a 185-kDa transmembrane glycoprotein that is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. It has no ligand binding domain of its own and therefore cannot bind growth factors. However,it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer,stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways,such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of HER2 have been reported in numerous cancers,including breast and ovarian tumors. HER2 is a therapeutic target for the treatment of breast cancer and other carcinomas.

This product can be used in analytical tools such as Western Blot.

At Innovative Research, we provide reliable, consistent products that deliver reliable, consistent results.

For research use only.

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This material is sold for in-vitro use only for manufacturing and research. This material is not suitable for human or animal use. While we make every effort to ensure the safety of our products, we recommend handling any biological materials with standard precautions as if capable of spreading infectious disease. The statements herin are offered for informational purposes only to be used solely for your consideration, investigation, and verification.

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