Mouse Anti Human Phospho-ERK 1/2 (Tyr222/205) Monoclonal Clone 4D4 from Innovative Research is a monoclonal antibody in a liquid format, buffered in PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4 This antibody has been purified using Protein A purification.

More Details:

• Host: Mouse
• Species: Human,Mouse,Rat
• Target: MAPK3
• Clonality: Monoclonal
• Immunogen: Synthetic Peptide of Phospho-ERK 1/2 (Tyr222/205)
• Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles.

Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4) and ARHGEF2.Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.

This product can be used in analytical tools such as IHC-p.

At Innovative Research, we provide reliable, consistent products that deliver reliable, consistent results.

For research use only.

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This material is sold for in-vitro use only for manufacturing and research. This material is not suitable for human or animal use. While we make every effort to ensure the safety of our products, we recommend handling any biological materials with standard precautions as if capable of spreading infectious disease. The statements herin are offered for informational purposes only to be used solely for your consideration, investigation, and verification.

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