Select this product for Molecular Innovations name, C1 Inhibitor Knockout Mouse and product number, MS-C1INH. 

At Innovative Research, we have worked to establish a broad range of working mouse research models to support many different therapeutic and disease areas of research. Our mouse models are fully licensed and maintained in cryopreservation, ready to be recovered based upon your order, in our Novi, MI facility under the care of full-time animal husbandry staff as well as on-site scientific and veterinary care. 

Our C1 Inhibitor Knockout Mouse Models were created via targeted gene excision using CRISPR-Cas9 technology licensed from the Broad Institute of MIT and Harvard targeting SERPING1. Mutations were then confirmed using various methods, including PCR genotyping, Sanger sequencing, and Western Blot. C1 Inhibitor is a serine protease inhibitor (serpin) that is involved in the contact and complement systems and could be a therapeutic target for a wide range of conditions including hereditary angioedema (HAE), hemorrhagic & septic shock, transplant rejection, and other inflammatory disorders.

Our C1 Inhibitor Knockout Mouse Models are available as homozygous mice, completely lacking all C1 Inhibitor protein expression.

Mouse Model Details:

• Strain: C57BL6/SJL
• Chromosome: 2
• Gene: SERPING1
• Genomic Target: Intron 1, Exon 8
• Mutation: 9244 Base Pair Deletion
• Phenotype: Absence of C1 Inhibitor protein expression, increased vascular permeability

In addition to the mouse models, we also offer a line of ready-to-use, genetically deficient plasma, organs, and tissue lysates that are ideal for use in applications like ELISA, Western Blot, and more. At Innovative Research, we provide reliable, consistent products that deliver reliable, consistent results.

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This material is sold for in-vitro use only for manufacturing and research. This material is not suitable for human or animal use. While we make every effort to ensure the safety of our products, we recommend handling any biological materials with standard precautions as if capable of spreading infectious disease. The statements herin are offered for informational purposes only to be used solely for your consideration, investigation, and verification.

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