*Human Pai 1 Recombinant P9 Nbd Labeled


Innovative Research

  • $741.00

Select this product for Molecular Innovations name, Human PAI-1 NBD labeled at P9 of the reactive center loop and product number, HPAI-P9NBD.

Human PAI-1 Recombinant P9-NBD Labeled from Innovative Research has been recombinantly produced in E. coli and purified by affinity chromatography. This is a Frozen liquid buffered in 0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 6.6 with a concentration of 2.5 mg/ml and a purity of >95% as determined by SDS-PAGE.

More Details:

  • Species: Human
  • Target: PAI-1
  • Purification Method: Affinity purified
  • Purity: >95% as determined by SDS-PAGE Analysis
  • Source: E. coli
  • Storage Conditions: -20C

Additional Information:
Created by mutagenesis of P9 serine residue (Ser338) to cysteine on the reactive center loop, providing a free thiol group for NBD labeling. Fluorescence emission is enhanced upon insertion of the reactive center loop into beta-sheet A (following the formation of complexes with proteinases, formation of the latent species, or cleavage by elastase). This modified version of PAI-1 is nearly as active as wild type PAI-1, but is more resistant to spontaneous latency reaction (making it suitable in applications like monitoring reaction rates of PAI-1).

This product can be used as a control in applications like ELISA and Western Blot. It can be used in a wide range of in vitro applications, including blocking/inhibition, fibrinolysis, plasminogen activation, receptor binding, in hypertension studies, for protein-protein interactions, and more. At Innovative Research, we provide reliable, consistent products that deliver reliable, consistent results.

Product References
Product Disclaimer

These products are supplied for manufacturing, research and laboratory use only. Researchers and laboratory personnel intending to use any of these products for medical investigation on humans are solely responsible for such use and for compliance with the pertinent regulations of the United States Food and Drug Administration (US-FDA) and other regulations. We do not assume liability for damages resulting from the handling, use and/or disposal of these products, from their use in violation of patent or other rights or reliance upon this information.

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