*Human Pai 1 Recombinant P14 Arginine Mutant Substrate

Select this product for Molecular Innovations name, Human PAI-1 (P14 Arg Substrate Mutant) and product number, HPAI-T333R.

Human PAI-1 Recombinant P14 Arginine Mutant Substrate from Innovative Research has been recombinantly produced in E. coli and purified by affinity chromatography. This is a Frozen liquid buffered in 0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 6.6 with a concentration of 2.5 mg/ml and a purity of >95% as determined by SDS-PAGE.

More Details:

• Species: Human
• Target: PAI-1
• Purification Method: Affinity purified
• Purity: >95% as determined by SDS-PAGE Analysis
• Source: E. coli
• Storage Conditions: -70C

Additional Information:
A single substitution in the reactive center loop (at P14) produces PAI-1 that functions as a substrate for proteinases rather than as an inhibitor. Reactive center loop insertion follows protease cleavage, and as a result, the PAI-1 loses its vitronectin binding properties. This molecule is useful for mechanistic studies.

This product can be used as a control in applications like ELISA and Western Blot. It can be used in a wide range of in vitro applications, including blocking/inhibition, fibrinolysis, plasminogen activation, receptor binding, in hypertension studies, for protein-protein interactions, and more. At Innovative Research, we provide reliable, consistent products that deliver reliable, consistent results.