*Human Pai 1 Recombinant P14 Arginine Mutant Substrate
IHUPAI1RP14SB500UGSelect this product for Molecular Innovations name, Human PAI-1 (P14 Arg Substrate Mutant) and product number, HPAI-T333R.
Human PAI-1 Recombinant P14 Arginine Mutant Substrate from Innovative Research has been recombinantly produced in E. coli and purified by affinity chromatography. This is a Frozen liquid buffered in 0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 6.6 with a concentration of 2.5 mg/ml and a purity of >95% as determined by SDS-PAGE.
More Details:
- Species: Human
- Target: PAI-1
- Purification Method: Affinity purified
- Purity: >95% as determined by SDS-PAGE Analysis
- Source: E. coli
- Storage Conditions: -70C
Additional Information:
A single substitution in the reactive center loop (at P14) produces PAI-1 that functions as a substrate for proteinases rather than as an inhibitor. Reactive center loop insertion follows protease cleavage, and as a result, the PAI-1 loses its vitronectin binding properties. This molecule is useful for mechanistic studies.
This product can be used as a control in applications like ELISA and Western Blot. It can be used in a wide range of in vitro applications, including blocking/inhibition, fibrinolysis, plasminogen activation, receptor binding, in hypertension studies, for protein-protein interactions, and more. At Innovative Research, we provide reliable, consistent products that deliver reliable, consistent results.
These products are supplied for manufacturing, research and laboratory use only. Researchers and laboratory personnel intending to use any of these products for medical investigation on humans are solely responsible for such use and for compliance with the pertinent regulations of the United States Food and Drug Administration (US-FDA) and other regulations. We do not assume liability for damages resulting from the handling, use and/or disposal of these products, from their use in violation of patent or other rights or reliance upon this information.
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