Human Pai 1 Recombinant P14 Arginine Mutant SubstrateIHUPAI1RP14SB500UG
Human PAI-1 Recombinant P14 Arginine Mutant Substrate from Innovative Research has been recombinantly produced in E. coli and purified by affinity chromatography. This is a Frozen liquid buffered in 0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 6.6 with a concentration of 2.5 mg/ml and a purity of >95% as determined by SDS-PAGE.
- Species: Human
- Target: PAI-1
- Purification Method: Affinity purified
- Purity: >95% as determined by SDS-PAGE Analysis
- Source: E. coli
- Storage Conditions: -70 C
A single substitution in the reactive center loop (at P14) produces PAI-1 that functions as a substrate for proteinases rather than as an inhibitor. Reactive center loop insertion follows protease cleavage, and as a result, the PAI-1 loses its vitronectin binding properties. This molecule is useful for mechanistic studies.
This product can be used as a control in applications like ELISA and Western Blot. It can be used in a wide range of in vitro applications, including blocking/inhibition, fibrinolysis, plasminogen activation, receptor binding, in hypertension studies, for protein-protein interactions, and more. At Innovative Research, we provide reliable, consistent products that deliver reliable, consistent results.
This material is sold for in-vitro use only for manufacturing and research. This material is not suitable for human or animal use. While we make every effort to ensure the safety of our products, we recommend handling any biological materials with standard precautions as if capable of spreading infectious disease. The statements herin are offered for informational purposes only to be used solely for your consideration, investigation, and verification.
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