Human tPA Purified Non-Enzymatic Non-CleavableIHUTPANENC100UG
Human tPA Purified Non-Enzymatic Non-Cleavable from Innovative Research has been recombinantly produced in insect cells and purified using affinity chromatography. This is a frozen liquid buffered in 0.4M HEPES; 0.1M NaCl; pH 7.4, with a concentration of 2.0 mg/ml and a purity of >95%.
This product is useful as a positive control for ELISA and western blot and for a variety of in vitro applications including cell differentiation, cell signaling, clotting assays, fibrinolysis, plasminogen activation, protein-protein interactions, receptor binding, thromboelastography, and thrombolysis. Human tPA with a double mutation that is permanently single chain and lacks catalytic activity. The non-catalytic mutation site is S478A on the mature protein and S513A on the complete mRNA sequence (UniProtKB: locus TPA_HUMAN, accession P00750). The non-cleavable mutation site is R275E on the mature protein and R310E on the complete mRNA sequence (UniProtKB: locus TPA_HUMAN, accession P00750).
- Source: Insect Cell Culture
- Purification: Affinity purified
- Purity: >95%
- Storage Conditions: -70 C
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Please note – this product replaces our old product number IHTPA-ALANC (same product, new number).
This material is sold for in-vitro use only for manufacturing and research. This material is not suitable for human or animal use. While we make every effort to ensure the safety of our products, we recommend handling any biological materials with standard precautions as if capable of spreading infectious disease. The statements herin are offered for informational purposes only to be used solely for your consideration, investigation, and verification.
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