*Human tPA Purified Non-Enzymatic Non-CleavableIHUTPANENC100UG
Select this product for Molecular Innovations name, Non-enzymatic, non-cleavable human tPA and product number, HTPA-ALANC.
Human tPA Purified Non-Enzymatic Non-Cleavable from Innovative Research has been recombinantly produced in insect cells and purified using affinity chromatography. This is a frozen liquid buffered in 0.4M HEPES; 0.1M NaCl; pH 7.4, with a concentration of 2.0 mg/ml and a purity of >95%.
This product is useful as a positive control for ELISA and western blot and for a variety of in vitro applications including cell differentiation, cell signaling, clotting assays, fibrinolysis, plasminogen activation, protein-protein interactions, receptor binding, thromboelastography, and thrombolysis. Human tPA with a double mutation that is permanently single chain and lacks catalytic activity. The non-catalytic mutation site is S478A on the mature protein and S513A on the complete mRNA sequence (UniProtKB: locus TPA_HUMAN, accession P00750). The non-cleavable mutation site is R275E on the mature protein and R310E on the complete mRNA sequence (UniProtKB: locus TPA_HUMAN, accession P00750).
- Source: Insect Cell Culture
- Purification: Affinity purified
- Purity: >95%
- Storage Conditions: -70 C
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Please note â€“ this product replaces our old product number IHTPA-ALANC (same product, new number).
These products are supplied for manufacturing, research and laboratory use only. Researchers and laboratory personnel intending to use any of these products for medical investigation on humans are solely responsible for such use and for compliance with the pertinent regulations of the United States Food and Drug Administration (US-FDA) and other regulations. We do not assume liability for damages resulting from the handling, use and/or disposal of these products, from their use in violation of patent or other rights or reliance upon this information.
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