
Human Protein C Purified GLA Domainless
IHUPROCGD100UGHuman Protein C Purified GLA Domainless from Innovative Research has been prepared from Human Protein C Purified using Cathepsin G to remove the gamma-carboxyglutamic acid region, followed by affinity chromatography to purify out the Cathepsin G. This is a frozen liquid buffered in 20 mM Tris-HCl/ 0.1 M NaCl/ 1mM Benzamidine/ pH 7.4, with a concentration of 1mg/ml.
Also known as Factor XIV, Protein C is a zymogen that, when activated, helps to regulate anticoagulation, inflammation, and more. Key to this process is the ability of Activated Protein C (in conjunction with cofactors) to inactivate Factor Va and Factor VIIIa. Protein C is activated by Thrombin, and can be down-regulated by reduction in EPCR and/or thrombomodulin (either of which can be triggered by inflammatory cytokines) and may be up-regulated by Platelet Factor 4. Protein C is inhibited by Protein C Inhibitor.
More Details:
- Source: Human Plasma
- Purification: Prepared from Human Protein C Purified using Cathepsin G, which was removed after digestion using affinity chromatography.
- Storage Conditions: -60° to -80°C
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Please note – this product replaces our old product number IRHPCGD (same product, new number).
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