Human Protein C Purified GLA DomainlessIHUPROCGD100UG
Human Protein C Purified GLA Domainless from Innovative Research has been prepared from Human Protein C Purified using Cathepsin G to remove the gamma-carboxyglutamic acid region, followed by affinity chromatography to purify out the Cathepsin G. This is a frozen liquid buffered in 20 mM Tris-HCl/ 0.1 M NaCl/ 1mM Benzamidine/ pH 7.4, with a concentration of 1mg/ml.
Also known as Factor XIV, Protein C is a zymogen that, when activated, helps to regulate anticoagulation, inflammation, and more. Key to this process is the ability of Activated Protein C (in conjunction with cofactors) to inactivate Factor Va and Factor VIIIa. Protein C is activated by Thrombin, and can be down-regulated by reduction in EPCR and/or thrombomodulin (either of which can be triggered by inflammatory cytokines) and may be up-regulated by Platelet Factor 4. Protein C is inhibited by Protein C Inhibitor.
- Source: Human Plasma
- Purification: Prepared from Human Protein C Purified using Cathepsin G, which was removed after digestion using affinity chromatography.
- Storage Conditions: -60° to -80°C
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Please note – this product replaces our old product number IRHPCGD (same product, new number).
These products are supplied for manufacturing, research and laboratory use only. Researchers and laboratory personnel intending to use any of these products for medical investigation on humans are solely responsible for such use and for compliance with the pertinent regulations of the United States Food and Drug Administration (US-FDA) and other regulations. We do not assume liability for damages resulting from the handling, use and/or disposal of these products, from their use in violation of patent or other rights or reliance upon this information.
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