Human Protein C Purified GLA DomainlessIHUPROCGD100UG
Human Protein C Purified GLA Domainless from Innovative Research has been prepared from Human Protein C Purified using Cathepsin G to remove the gamma-carboxyglutamic acid region, followed by affinity chromatography to purify out the Cathepsin G. This is a frozen liquid buffered in 20 mM Tris-HCl/ 0.1 M NaCl/ 1mM Benzamidine/ pH 7.4, with a concentration of 1mg/ml.
Also known as Factor XIV, Protein C is a zymogen that, when activated, helps to regulate anticoagulation, inflammation, and more. Key to this process is the ability of Activated Protein C (in conjunction with cofactors) to inactivate Factor Va and Factor VIIIa. Protein C is activated by Thrombin, and can be down-regulated by reduction in EPCR and/or thrombomodulin (either of which can be triggered by inflammatory cytokines) and may be up-regulated by Platelet Factor 4. Protein C is inhibited by Protein C Inhibitor.
- Source: Human Plasma
- Purification: Prepared from Human Protein C Purified using Cathepsin G, which was removed after digestion using affinity chromatography.
- Storage Conditions: -60° to -80°C
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Please note – this product replaces our old product number IRHPCGD (same product, new number).
This material is sold for in-vitro use only for manufacturing and research. This material is not suitable for human or animal use. While we make every effort to ensure the safety of our products, we recommend handling any biological materials with standard precautions as if capable of spreading infectious disease. The statements herin are offered for informational purposes only to be used solely for your consideration, investigation, and verification.
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