Human / Mouse TNF-alpha multimeric Recombinant Protein DDDDK Tag Lyophilized from Innovative Research has been recombinantly produced in HEK293 cells. This is a Lyophilized protein buffered in Contains PBS. Reconstitute with 100 and#956;l sterile water. with a purity of >95% (SDS-PAGE).

Endotoxin level is less than 0.02EU/ and#956;g purified protein (LAL test; Lonza)..

More Details:

• Species: Human, Mouse
• Target: TNF
• Purity: >95% (SDS-PAGE).
  
  Endotoxin level is less than 0.02EU/ and#956;g purified protein (LAL test; Lonza).
• Source: HEK293 cells
• Storage Conditions: Stable for at least 6 months after receipt when stored at -20°C.

Additional Information:

Tumor necrosis factor (TNF, cachexin or cachectin and formerly known as tumor necrosis factor-alpha) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. MultimericTNF-alpha™ is a high activity construct in which two trimeric TNF-alpha ligands are artificially linked via the collagen domain of ACRP30. The receptor TNF-R1 is activated by both the membrane-bound and soluble trimeric forms of TNF-alpha, whereas the receptor TNF-R2 only responds to the membrane-bound form of TNF-alpha (TNF-alpha (human) (multimeric) (rec. ) (Prod. No. AG-40B-0019). Since the MultimericTNF-alpha™ mimics the membrane-bound form (forms oligomers higher than trimer), it is the only TNF-alpha protein that can activate the TNF-R2. For TNF-R1 activation, either "normal" TNF-alpha or MultimericTNF-alpha™ can be used.

This recombinant proteins is for research use only.. At Innovative Research we provide reliable, consistent products that deliver reliable, consistent results.

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This material is sold for in-vitro use only for manufacturing and research. This material is not suitable for human or animal use. While we make every effort to ensure the safety of our products, we recommend handling any biological materials with standard precautions as if capable of spreading infectious disease. The statements herin are offered for informational purposes only to be used solely for your consideration, investigation, and verification.

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