Human Kynurenine Aminotransferase II Recombinant Protein His Tag from Innovative Research has been recombinantly produced in E. coli. This is a Liquid protein buffered in In 50 mM phosphate buffer pH 8.0, containing 50mM sodium chloride and 40uM pyridoxal 5'-phosphate (PLP). with a purity of >97% (SDS-PAGE).

More Details:

• Species: Human
• Target: AADAT
• Purity: >97% (SDS-PAGE)
• Source: E. coli
• Storage Conditions: Stable for at least 6 months after receipt when stored at -80°C.

Additional Information:

Kynurenine aminotransferases (KATs) are pyridoxal-5’-phosphate-dependent enzymes that catalyze the conversion of L-kynurenine into kynurenic acid, a neuroactive metabolite whose unbalancing is associated with a number of brain disorders. Biochemical and structural investigations revealed that L-kynurenine (L-KYN) recognition by hKAT II is achieved by exploiting structural features that are peculiar of this isoform, thus offering the possibility to select/design inhibitor molecules specifically targeting hKAT II to be used as modulators of kynurenic acid synthesis in the CNS. hKAT II is one of the aminotransferases involved in the pyridoxal 5'-phosphate (PLP)-dependent irreversible transamination of L-kynurenine (L-KYN) to kynurenic acid (KYNA) in the central nervous system. When assayed in vitro the protein also displays beta-elimination activity.

This recombinant proteins is for research use only.. At Innovative Research we provide reliable, consistent products that deliver reliable, consistent results.

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This material is sold for in-vitro use only for manufacturing and research. This material is not suitable for human or animal use. While we make every effort to ensure the safety of our products, we recommend handling any biological materials with standard precautions as if capable of spreading infectious disease. The statements herin are offered for informational purposes only to be used solely for your consideration, investigation, and verification.

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