Human Integrin alpha 4 Recombinant Protein N-terminal His Tag

Human Integrin alpha 4 Recombinant Protein N-terminal His Tag from Innovative Research has been recombinantly produced in E. coli. This is a Liquid protein buffered in 50mM Tris pH7.5, 150mM NaCl, 5 mM MgCl2 with a purity of ~95%.

More Details:

• Species: Human
• Target: ITGA4
• Purity: ~95%
• Source: E. coli
• Storage Conditions: Store in working aliquots at -70°C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Additional Information:

The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains (reviewed in 1). Alpha 4 (?4) chain associates with either beta 1 (?1) or beta 7???7) chain. It has been demonstrated that the putative ligand-binding sites of both integrin ?4?1 and ?4?7 is located on the ?4 chain. These ligands included Madcam, VCAM, and fibronectin (2-4). Madcam is known as the principal ligand for integrin a4b7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin ?4?7, the gut mucosal homing receptor for peripheral T cells (5). This recombinant protein fragment includes the ligand and monoclonal antibody binding domains; this binding has been tested and verified in ELISA assays. This recombinant protein is recognized PSI antibodies Integrin 4? (IN1) (PSI 4827) and Integrin 4? (IN2) (PSI 4837), but not Integrin 4? (CT) (PSI 4783).

This recombinant protein can be used for WB and ELISA. For research use only. . At Innovative Research we provide reliable, consistent products that deliver reliable, consistent results.

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This material is sold for in-vitro use only for research. This material is not suitable for human or animal use. While we make every effort to ensure the safety of our products, we recommend handling any biological materials with standard precautions as if capable of spreading infectious disease. The statements herein are offered for informational purposes only to be used solely for your consideration, investigation, and verification.

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