Human IL-15 mutant Recombinant Protein Fc Tag Lyophilized from Innovative Research has been recombinantly produced in CHO cells. This is a Lyophilized protein buffered in Lyophilized from 0.2um-filtered solution in PBS. Reconstitute in 50 and#956;l sterile water. Add 1X PBS to the desired protein concentration. with a purity of >98% (SDS-PAGE). Endotoxin level is less than 0.06EU/ and#956;g protein (LAL test; Lonza)..More Details: Species: Human Target: IL15 Purity: >98% (SDS-PAGE). Endotoxin level is less than 0.06EU/ and#956;g protein (LAL test; Lonza). Source: CHO cells Storage Conditions: Stable for at least 1 year after receipt when stored at -20░C. Working aliquots are stable for up to 3 months when stored at -20░C.
Additional Information:
Interleukin-15 (IL-15) has a broad spectrum of biological activities. It is crucial for the development, proliferation, survival and differentiation of multiple cells from both innate and adaptive immune systems. IL-15 up-regulation has a central role in the development of several autoimmune or chronic inflammatory disorders. Targeting IL-15 or its receptor may have a valuable impact on the treatment of immune-mediated diseases. IL-15 participates in the development of important immune antitumor mechanisms. It activates CD8(+) T cells, natural killer (NK) cells, NK T cells, and can promote the formation of antitumor antibodies. IL-15 can also protect T effector cells from the action of T regulatory cells and reverse tolerance to tumor-associated antigens. In pre-clinical studies IL-15 has been found to demonstrate potentiated antitumor effects following pre-association with IL-15Ralpha, or when used in combination with chemotherapy, adoptive therapy, monoclonal antibodies, and tumor vaccines.This recombinant proteins is for research use only.. At Innovative Research we provide reliable, consistent products that deliver reliable, consistent results.
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