Human IL-15 mutant Recombinant Protein (biotin) Fc Tag Lyophilized from Innovative Research has been recombinantly produced in CHO cells. This is a Lyophilized protein buffered in In PBS and 0.09% sodium azide. with a purity of >98% (SDS-PAGE).
Endotoxin level is less than 0.06EU/ and#956;g protein (LAL test; Lonza)..
More Details:
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Species: Human
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Target: IL15
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Purity: >98% (SDS-PAGE).
Endotoxin level is less than 0.06EU/ and#956;g protein (LAL test; Lonza).
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Source: CHO cells
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Storage Conditions: Stable for at least 6 months after receipt when stored at +4°C.
Additional Information:
Interleukin-15 (IL-15) has a broad spectrum of biological activities. It is crucial for the development, proliferation, survival and differentiation of multiple cells from both innate and adaptive immune systems. IL-15 up-regulation has a central role in the development of several autoimmune or chronic inflammatory disorders. Targeting IL-15 or its receptor may have a valuable impact on the treatment of immune-mediated diseases. IL-15 participates in the development of important immune antitumor mechanisms. It activates CD8(+) T cells, natural killer (NK) cells, NK T cells, and can promote the formation of antitumor antibodies. IL-15 can also protect T effector cells from the action of T regulatory cells and reverse tolerance to tumor-associated antigens. In pre-clinical studies IL-15 has been found to demonstrate potentiated antitumor effects following pre-association with IL-15Ralpha, or when used in combination with chemotherapy, adoptive therapy, monoclonal antibodies, and tumor vaccines.
Application: Useful for immunofluorescent staining and flow cytometric analysis to identify and enumerate IL-15Ralpha expressing cells within mixed cell populations.
This recombinant proteins is for research use only.. At Innovative Research we provide reliable, consistent products that deliver reliable, consistent results.
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