Human Gremlin-1 Recombinant Protein Lyophilized from Innovative Research has been recombinantly produced in CHO cells. This is a Lyophilized protein buffered in with a purity of Greater than 90% by SDS-PAGE gel and HPLC analyses..More Details: Species: Human Target: GREM1 Purity: Greater than 90% by SDS-PAGE gel and HPLC analyses. Source: CHO cells Storage Conditions: The lyophilized Gremlin-1 recombinant protein is stable for at least 2 years from date of receipt at -20░C. Reconstituted Gremlin-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20░C. As with any protein, exposing Gremlin-1 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Additional Information:

Gremlin-1 (isoform-1) belongs to a group of diffusible proteins which bind to ligands of the TGF-and#946; family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-and#946; ligands and their natural anTagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Gremlin is highly expressed in the small intestine, fetal brain, and colon and lower expression in brain, prostate, pancreas and skeletal muscle. Gremlin-1 regulates multiple functions in early development by specifically binding to and inhibiting the function of BMP-2, -4, and -7. It also plays a role in carcinogenesis and kidney branching morphogenesis. Recombinant Gremlin-1 is a 13.7 kDa protein containing 160 amino acid residues.. At Innovative Research we provide reliable, consistent products that deliver reliable, consistent results.

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This material is sold for in-vitro use only for manufacturing and research. This material is not suitable for human or animal use. While we make every effort to ensure the safety of our products, we recommend handling any biological materials with standard precautions as if capable of spreading infectious disease. The statements herin are offered for informational purposes only to be used solely for your consideration, investigation, and verification.

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