Select this product for Molecular Innovations name, Human C1q, Human Plasma and product number, HC1Q.

Human Complement C1Q Purified from Innovative Research has been purified from human plasma. This product is offered in a frozen liquid format, buffered in 0.01M HEPES; 0.3M NaCl; pH 7.2, with a purity of >98% by SDS-PAGE analysis.

Human Complement Component 1q (C1q) is a high molecular weight complex of six trimers, each consisting of an A, B, and C chain. Complement C1 is the first component in the classical complement cascade and circulates in plasma as a calcium-dependent complex of C1q, C1r, and C1s. C-terminal C1q globular domains bind to Fc regions of IgM or IgG present in immune complexes while N-terminal C1q collagen-like regions interact with the C1r₂C1s₂ proenzyme complex. C1q circulates in normal serum at 113 ug/ml. Patients deficient in C1q are prone to systemic lupus erythematosus (SLE) and glomerulonephritis as well as recurrent infection and skin lesions. Specific Haemolytic Complement activity is determined by lysis of antibody sensitized sheep red blood cells with C1q deficient human serum. Prepared from plasma shown to be non reactive for HbsAG, HTLV-I/II, STS, and negative for anti-HCV, anti-HIV-1, and anti-HIV-2 by FDA approved tests. >98percent pure by SDS-PAGE.

More Details:

• Source: Human plasma
• Purity: >98% by SDS-PAGE analysis
• Buffer: 0.01M HEPES, 0.3m NaCl, pH 7.2
• Storage Conditions: -70C or below. Avoid repeated freeze/thaw cycles
• Thawing Process: Thaw quickly, 37C, then mix. Put in an ice and water bath to cool
• Activity: >150,000 C1qH50 Units/mg

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This material is sold for in-vitro use only for manufacturing and research. This material is not suitable for human or animal use. While we make every effort to ensure the safety of our products, we recommend handling any biological materials with standard precautions as if capable of spreading infectious disease. The statements herin are offered for informational purposes only to be used solely for your consideration, investigation, and verification.

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