Human ANGPTL4 fibrinogen-like domain Recombinant Protein DDDDK Tag from Innovative Research has been recombinantly produced in HEK293 cells. This is a Liquid protein buffered in 0.2um-filtered solution in PBS. with a purity of >90% (SDS-PAGE).

Endotoxin level is less than 0.1EU/ and#956;g purified protein (LAL test; Lonza)..

More Details:

• Species: Human
• Target: ANGPTL4
• Purity: >90% (SDS-PAGE).
  
  Endotoxin level is less than 0.1EU/ and#956;g purified protein (LAL test; Lonza).
• Source: HEK293 cells
• Storage Conditions: Working aliquots are stable for up to 3 months when stored at -20°C.

Additional Information:

ANGPTL4 (Angiopoietin-like protein 4) mainly expressed in endothelial cells (hypoxia-induced). Regulates angiogenesis and modulates tumorigenesis and directly regulates lipid, glucose, and energy metabolism. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 is a protein consisting of an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain (FLD). Both domains have distinct biological functions. The coiled-coil domain is responsible for the inhibitory effects on lipoprotein lipase (LPL) converting the active form of LPL into an inactive form, and the FLD domain mediates its antiangiogenic functions. The coiled coil and the FLD domains are separated by a short linker that can be cleaved after secretion. ANGPTL4 appears on the cell surface as the full-length form, where it can be released by heparin treatment. ANGPTL4 protein is then proteolytically cleaved by proprotein convertases (PCs), including furin, PC5/6, paired basic amino acid-cleaving enzyme 4, and PC7.

This recombinant proteins is for research use only.. At Innovative Research we provide reliable, consistent products that deliver reliable, consistent results.

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This material is sold for in-vitro use only for manufacturing and research. This material is not suitable for human or animal use. While we make every effort to ensure the safety of our products, we recommend handling any biological materials with standard precautions as if capable of spreading infectious disease. The statements herin are offered for informational purposes only to be used solely for your consideration, investigation, and verification.

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