Bacteria-Derived Oncomodulin-1 Recombinant Protein N-6His Tag Lyophilized

Bacteria-Derived Oncomodulin-1 Recombinant Protein N-6His Tag Lyophilized from Innovative Research has been recombinantly produced in E.coli. The protein formulation is lyophilized from a 0.2 ?m filtered solution of 50mM Tris, 100mM NaCl, pH 7.5. with a purity of > 95 % as determined by reducing SDS-PAGE..

More Details:

• Species: Human
• Target: Oncomodulin-1
• Purity: > 95 % as determined by reducing SDS-PAGE..< 1.0 EU per ug as determined by the LAL method.
• Source: E.coli
• Storage Conditions: Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8? for 2-7 days. Aliquots of reconstituted samples are stable at < -20? for 3 months.

Oncomodulin-1 (OM) is a small, calcium-binding protein and a macrophage-derived growth factor, which can promote axon regeneration in retinal ganglion cells. Oncomodulin-1 is constitutively secreted by activated macrophages in the vitreous and retina in response to inflammatory conditions that promote optic nerve regeneration. Oncomodulin-1 binds RGCs with high affinity in vitro, but only when cAMP is pharmacologically elevated or if the membrane is permeabilized allowing Oncomodulin-1 access to the cytosolic compartment. Oncomodulin-1 is a member of the superfamily of calmodulin proteins and is a high-affinity calcium ion-binding protein and contains 2 EF-hand domains. OM is found in early embryonic cells in the placenta and also in tumors. It has some calmodulin-like activity with respect to enzyme activation and growth regulation.

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