Bacteria-Derived LMCD1 Recombinant Protein N,C-6His Tag from Innovative Research has been recombinantly produced in E.coli. The protein formulation is supplied as a 0.2 ?m filtered solution of 20mM PB?150mM NaCl,pH7.4. with a purity of > 95 % as determined by reducing SDS-PAGE..

More Details:

• Species: Human
• Target: LMCD1
• Purity: > 95 % as determined by reducing SDS-PAGE..< 1.0 EU per ug as determined by the LAL method.
• Source: E.coli
• Storage Conditions: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

LMCD1 is transcriptional cofactor which contains a cysteine-rich domain in the N-terminal region and 2 LIM domains in the C-terminal region. It also has several potential phosphorylation and N-myristoylation sites and a single potential N-glycosylation site. LMCD1 is expressed in many tissues with highest abundance in skeletal muscle. LMCD1 restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. It plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.

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This material is sold for in-vitro use only for manufacturing and research. This material is not suitable for human or animal use. While we make every effort to ensure the safety of our products, we recommend handling any biological materials with standard precautions as if capable of spreading infectious disease. The statements herin are offered for informational purposes only to be used solely for your consideration, investigation, and verification.

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