Bacteria-Derived IL-33 Recombinant Protein His Tag

Bacteria-Derived IL-33 Recombinant Protein His Tag from Innovative Research has been recombinantly produced in E. coli. This is a Liquid protein buffered in 0.2um-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl. with a purity of >90% (SDS-PAGE).

Endotoxin level is less than 1EU/ and#956;g purified protein (LAL test; Lonza)..

More Details:

• Species: Bacteria-Derived
• Target: IL33
• Purity: >90% (SDS-PAGE).
  
  Endotoxin level is less than 1EU/ and#956;g purified protein (LAL test; Lonza).
• Source: E. coli
• Storage Conditions: Working aliquots are stable for up to 3 months when stored at -20°C.

Additional Information:

Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kDa human IL33 is converted by CASP1 to a 18kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy and anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.

This recombinant proteins is for research use only.. At Innovative Research we provide reliable, consistent products that deliver reliable, consistent results.

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This material is sold for in-vitro use only for research. This material is not suitable for human or animal use. While we make every effort to ensure the safety of our products, we recommend handling any biological materials with standard precautions as if capable of spreading infectious disease. The statements herein are offered for informational purposes only to be used solely for your consideration, investigation, and verification.

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