Bacteria-Derived HIP2 Recombinant Protein N-6His Tag from Innovative Research has been recombinantly produced in E.coli. The protein formulation is supplied as a 0.2 ?m filtered solution of 20mM PB;150mM NaCl;pH7.4. with a purity of > 90 % as determined by reducing SDS-PAGE..

More Details:

• Species: Human
• Target: HIP2
• Purity: > 90 % as determined by reducing SDS-PAGE..< 1.0 EU per ug as determined by the LAL method.
• Source: E.coli
• Storage Conditions: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Ubiquitin-Conjugating Enzyme E2 K (UBE2K) belongs to the E2 Ubiquitin-Conjugating Enzyme family. UBE2K is highly expressed in the brain; with highest levels found in cortex and striatum; and at lower levels in cerebellum and brainstem. UBE2K may mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. UBE2K is associated with the selective degradation of short-lived and abnormal proteins; such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. In addition; UBE2K is involved in Alzheimer's disease; Huntington's disease and antigen processing through its interaction with huntingtin; and MHC-heavy chain proteins.

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This material is sold for in-vitro use only for manufacturing and research. This material is not suitable for human or animal use. While we make every effort to ensure the safety of our products, we recommend handling any biological materials with standard precautions as if capable of spreading infectious disease. The statements herin are offered for informational purposes only to be used solely for your consideration, investigation, and verification.

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