Bacteria-Derived 14-3-3 sigma Recombinant Protein Lyophilized

Bacteria-Derived 14-3-3 sigma Recombinant Protein Lyophilized from Innovative Research has been recombinantly produced in E.coli. The protein formulation is lyophilized from sterile 20mM Tris; 150mM NaCl; 10mM GSH; 25% glycerol; pH 8.0 with a purity of > 97 % as determined by reducing SDS-PAGE..

More Details:

• Species: Human
• Target: 14-3-3 sigma
• Purity: > 97 % as determined by reducing SDS-PAGE..Please contact us for more information.
• Source: E.coli
• Storage Conditions: Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8? for 2-7 days. Aliquots of reconstituted samples are stable at < -20? for 3 months.

14-3-3 protein sigma (YWHAS); also known as stratifin (SFN) and epithelial cell marker protein 1; is a member of the14-3-3 proteins which are a family of conserved regulatory molecules expressed in all eukaryotic cells. The name 14-3-3 refers to the particular elution and migration pattern of these proteins on DEAE-cellulose chromatography and starch-gel electrophoresis. The 14-3-3 proteins eluted in the 14th fraction of bovine brain homogenate and were found on positions 3.3 of subsequent electrophoresis. There are seven genes that encode 14-3-3s in most mammals. 14-3-3 proteins have been identified as adapter proteins implicated in the regulation of a large spectrum of both general and specialized signaling pathway. More than 100 signaling proteins have been reported as 14-3-3 ligands including kinases; phosphatases; and transmembrane receptors; and the binding generally results in the modulation of the activity of the binding partner. YWHAE exists as a homodimer and present mainly in tissues enriched in stratified squamous keratinising epithelium. YWHAS has been repoted to interact with KRT17 and GAB2; and may regulate protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway upon binding to KRT17. Additionally; YWHAS (SFN) may also act as a p53-regulated inhibitor of G2/M progression.

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